Mendelian Randomization Analysis Reveals a Causal Relationship Between Membranous Nephropathy and the Gut Microbiome.

Background: With the increasing prevalence of membranous nephropathy (MN), the gut microbiome (GM) is increasingly implicated in its cause, yet the intricate mechanisms remain unclear. Whether changes in the diversity and richness of gut microbial populations among MN patients contribute to disease prevalence is still unanswered, necessitating further exploration into the potential causative link between the GM and MN.

Methods: We conducted a comprehensive bidirectional Mendelian randomization (MR) study.

Changes of FGF23 and hearing in chronic renal failure and their correlation analysis.

Background: To explore the association between fibroblast growth factor 23 (FGF23) and hearing in chronic renal failure (CRF).

Methods: Pure tone audiometry was used to detect the hearing of patients with CRF; the level of serum FGF23, creatinine, blood urea nitrogen (BUN), parathyroid hormone (PTH), and mean binaural hearing threshold were compared to the control group (people without kidney disease). The rat model of renal failure was established by 5/6 nephrectomy, and the auditory brainstem response (ABR) of rats after modeling was detected by the Tucker Davis Technologies (TDT) system; the expression level of FGF23 in the peripheral blood, renal and cochlear tissue was also detected.

Predictive value of serum d-serine level for hearing impairment in uremic patients.

Objective: To investigate the predictive value of serum d-serine level for hearing impairment (HI) in uremic patients.

Methods: In this study, 30 uremic patients with HI and 30 with normal hearing were selected. The basic conditions, biochemical indicators, and serum serine levels of the two groups were compared to analyze the influencing factors of HI.

Correlation study of FGF23/D-serine in maintenance hemodialysis patients with combined hearing impairment.

Background: Recent studies have reported an association between chronic renal failure and hearing impairment. Yet, the exact mechanism of action is still not fully understood. In this study, we investigated the expression of fibroblast growth factor 23 (FGF23) and D-serine in maintenance hemodialysis (MHD) patients with end-stage renal disease (ESRD) complicated with hearing impairment and further investigated the correlation between FGF23/D-serine and hearing impairment.