Functional impairment in patients with sporadic Inclusion Body Myositis.

Introduction: We conducted a retrospective chart review of 53 patients diagnosed with sporadic Inclusion Body Myositis (sIBM) who have been followed at the McMaster Neuromuscular Clinic since 1996.

Objectives: We reviewed patient medical histories in order to compare our findings with similar cohorts, and analyzed quantitative strength data to determine functionality in guiding decisions related to gait assistive devices.

Methods: Patient information was acquired through retrospective clinic chart review.

The Otto Aufranc Award. On the etiology of the cam deformity: a cross-sectional pediatric MRI study.

Background: Femoroacetabular impingement (FAI) has been recognized as a common cause of hip pain as well as a cause of hip arthritis, yet despite this, little is known about the etiology of the cam morphology or possible risk factors associated with its development.

Questions/purposes: The purposes of our study were to determine when the cam morphology associated with FAI developed in a cross-sectional cohort study of pediatric patients pre- and postphyseal closure using MRI and whether increased activity level during the period of physeal closure is associated with an increased likelihood that the cam deformity will develop.

Methods: Alpha angles were measured at the 3 o'clock (anterior head-neck junction) and 1:30 (anterosuperior head-neck junction) positions in both hips with a cam deformity defined as an alpha angle ≥ 50.

Sexual assault services delivered by SANEs.

Sexual Assult Nurse Examiner (SANE) programs have become the standard of care for sexual assault victims in many urgent care settings. This study examines SANE clinical nursing practices at one Canadian sexual assault urgent care centre.

Cognitive changes in children treated for acute lymphoblastic leukemia with chemotherapy only according to the Pediatric Oncology Group 9605 protocol.

The purpose of this study was to examine cognitive functioning and neuroimaging in children with leukemia treated with the Pediatric Oncology Group 9605 protocol at the Children's Hospital of Eastern Ontario. Mean age at diagnosis was 4.88 +/- 2.

Acute forensic medical procedures used following a sexual assault among treatment-seeking women.

Despite the negative physical and mental health outcomes of sexual assault, a minority of sexually assaulted women seek immediate post-assault medical and legal services. This study identified the number and types of acute forensic medical procedures used by women presenting at a hospital-based urgent care centre between 1997 and 2001 within 72 hours following a reported sexual assault. The study also examined assault and non-assault factors associated with the use of procedures.

Significance of the clinical course and early upper gastrointestinal studies in predicting complications associated with repair of esophageal atresia.

Background/purpose: In many centers, use of upper gastrointestinal (UGI) contrast studies in the early postoperative period after esophageal atresia (EA) repair is considered routine. Indications for this are many, including searching for existing problems and predicting future complications. However, most major complications, both early and late, usually are identified clinically before any radiologic studies.

Validation of the Ottawa Ankle Rules in children with ankle injuries.

Objectives: The Ottawa Ankle Rules (OAR) have been found to be 100% sensitive in adult patients with ankle injuries, and application of the OAR has resulted in a 28% reduction in the number of x-rays ordered. The objectives of this study were to determine the sensitivity and specificity of the OAR in children and to determine the potential change in x-ray utilization.

Methods: Children, aged 2-16 years, presenting to the EDs of two children's hospitals, with an ankle injury in the previous 48 hours, were enrolled.

High-flow priapism associated with Fabry's disease in a child: a case report and review of the literature.

We report a case of priapism in an 11-year-old boy known to have Fabry's disease. High flow was confirmed by color flow Doppler ultrasound and intracorporal blood gas measurements. Successful treatment was achieved by unilateral percutaneous Gelfoam embolization of the left internal pudendal artery.

A child with an intra-abdominal testicular teratoma: a case report and review of prepubertal cryptorchid germ cell tumors.

Objectives: We report the case of a tumor in an intra-abdominal cryptorchid testis of a 7-month-old male infant. Torsion of a testicular teratoma was confirmed by pathologic examination. A review was undertaken to identify and characterize other reports of prepubertal cryptorchid germ cell neoplasms.

Effect of diet and training on muscle glycogen storage and utilization in sled dogs.

Two groups of eight Alaskan huskies fed either a high-fat (HFD; 60% kcal from fat and 15% kcal from carbohydrate) or a high-carbohydrate diet (HCD; 60% kcal from carbohydrate and 15% kcal from fat) performed standard aerobic (1 h at 4 m/s on a 0% slope) and anaerobic (3 min at 6.7 m/s on a 10% slope) tests before and after training. Before and immediately after each exercise test, venous blood samples were collected and analyzed for lactate and pyruvate, and muscle biopsies were obtained under local anesthesia from the semitendinosus muscle and analyzed for total muscle glycogen (TMG) concentration.

Lipid metabolite responses to diet and training in sled dogs.

Two groups of Alaskan Huskies were fed either a high fat (HFD) or a high carbohydrate diet 4 wk before and during an 8-wk conditioning program. Aerobic bouts of exercise were performed before and after conditioning. Blood samples taken before and after each exercise test were analyzed for serum concentrations of free fatty acids (FFA), triglycerides (TG), vitamin E, glucose and serum lipase activity.

Plain film and CT observations in prostaglandin-induced bone changes.

Prostaglandin E1 intravenous infusion is used in infants with ductal-dependent congenital heart disease to maintain ductal patency and prolong life until palliative or corrective surgery is feasible. Complications of prostaglandin administration include fever, diarrhoea, hypotension, apnoea, bradycardia, pseudowidening of the cranial sutures, underossification of the calvarial bones, periostitis, and skin edema [1-3]. This paper presents dramatic plain radiographic features of prostaglandin-induced bone disease, including periosteal proliferation and the unusual bone-within-bone appearance, and provides the previously unpublished CT correlation.

Atypical hepatic vein leiomyoma extending into the right atrium: an unusual cause of the Budd-Chiari syndrome.

A 14-year-old male presented with a one week history of weakness, lightheadedness and vomiting. Bilateral pleural effusions were evident on chest radiography; electrocardiogram revealed decreased voltages. Echocardiogram, abdominal ultrasound and magnetic resonance imaging revealed a mass in an hepatic vein and the inferior vena cava extending up to and filling the right atrium.

Atypical leiomyoma arising in an hepatic vein with extension into the inferior vena cava and right atrium. Report of a case in a child.

We report an atypical leiomyoma arising in an hepatic vein and extending into the inferior vena cava and right atrium in a fourteen year old boy. US, CT and MRI facilitated diagnosis and removal of this tumor.

MRI of periprostatic venous plexus in staging of early prostatic carcinoma.

The periprostatic venous plexus can be observed as a bright rim in coronal magnetic resonance (MR) images obtained by spin-echo (SE) 2060/60 technique. A carcinoma of the prostate which penetrates through the capsule into the periprostatic tissues interrupts or obliterates this rim, whereas an intact rim indicates that the tumor is confined within the prostatic capsule. One hundred patients with proven prostatic carcinoma were prospectively imaged by MR to detect periprostatic involvement.

Magnetic resonance imaging, computed tomography, and radionuclide scintigraphy in detection of liver metastases.

A series of 100 patients with suspected hepatic metastases was studied with magnetic resonance (MR), unenhanced computed tomography (CT), and radionuclide (RN) scintigraphy. Each set of images was read by three clinicians using a five-point scale to allow receiver operating characteristic (ROC) analysis using truth data derived from clinical review. Performance was measured by the areas under the ROC curves (0.

Magnetic resonance imaging of retroperitoneal lymphadenopathy.

A prospective study was performed to determine the value of magnetic resonance imaging (MRI) in the detection of retroperitoneal lymphadenopathy. Fifty patients with known malignancy, who demonstrated enlarged lymph nodes on computed tomography (CT), were entered into the study. The best visualization of retroperitoneal lymphadenopathy was found with a multislice spin-echo pulse sequence having a repetition time of 2000 msec, and echo delay of 30 msec.

Mediastinal lymph node metastases from bronchogenic carcinoma: detection with MR imaging and CT.

Magnetic resonance (MR) imaging and computed tomography (CT) were compared in a prospective study of 48 patients for the detection of metastatic mediastinal lymphadenopathy from bronchogenic carcinoma. The images were interpreted by three experienced radiologists using a five-point rating scale, enabling receiver operating characteristic (ROC) analysis. Imaging results were evaluated against "truth" data based on analysis of surgical specimens from mediastinoscopy and thoracotomy.

Magnetic resonance imaging of the mediastinum.

Seven normal volunteers and 69 patients with known disease in either the mediastinum or hila or both were imaged using a prototype magnetic resonance imager operating at 0.15T. Normal mediastinal and hilar structures were readily identified and mediastinal diseases were well demonstrated by magnetic resonance imaging (MRI).

Placental site, parity, and date of quickening.

The influence of placental site and parity on the date of quickening was studied in 112 gravidas. With placental site on the anterior uterine wall, quickening occurred at a mean gestational age of 19 weeks in primigravidas, and 17 weeks, five days in multiparas. With placental site on the posterior uterine wall, quickening occurred at a mean gestational age of 18 weeks in primigravidas, and 16 weeks, one day in multiparas.