The modulatory effect of crotoxin and its phospholipase A subunit from Crotalus durissus terrificus venom on dendritic cells interferes with the generation of effector CD4 T lymphocytes.

Dendritic Cells (DCs) direct either cellular immune response or tolerance. The crotoxin (CTX) and its CB subunit (phospholipase A) isolated from Crotalus durissus terrificus rattlesnake venom modulate the DC maturation induced by a TLR4 agonist. Here, we analyzed the potential effect of CTX and CB subunit on the functional ability of DCs to induce anti-ovalbumin (OVA) immune response.