Publications by authors named "Dung Cao Tran"
Article Synopsis
- A 74-year-old man with severe aplastic anaemia achieved a long-term remission due to the growth of HLA allele-deficient clones, despite initial treatment complications.
- After starting eltrombopag and ciclosporin, his blood counts eventually normalized over a span of 3 years, showing a complete recovery of blood cell production.
- Research techniques like flow cytometry and deep sequencing indicated that his recovery relied on clones with mutations that interfered with antigen presentation, demonstrating a potential new approach for managing immune-related aplastic anaemia in similar patients.
Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disease characterized by intravascular hemolysis, thrombosis, and bone marrow (BM) failure. Although PNH is caused by excessive proliferation of hematopoietic stem cell (HSC) clones with loss of function mutations in phosphatidylinositol N-acetylglucosaminyltransferase subunit A () genes, what drives PNH clones to expand remains elusive.
Case Description: We present a case of a 26-year-old female who presented with hemolytic anemia, thrombocytopenia, and leukopenia.
Leukocytes that lack HLA allelic expression are frequently detected in patients with acquired aplastic anemia (AA) who respond to immunosuppressive therapy (IST), although the exact mechanisms underlying the HLA loss and HLA allele repertoire likely to acquire loss-of-function mutations are unknown. We identified a common nonsense mutation at position 19 (c.19C>T, p.
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