Tracking electricity losses and their perceived causes using nighttime light and social media.

Urban environments are intricate systems where the breakdown of critical infrastructure can impact both the economic and social well-being of communities. Electricity systems hold particular significance, as they are essential for othe infrastructure, and disruptions can trigger widespread consequences. Typically, assessing electricity availability requires ground-level data, a challenge in conflict zones and regions with limited access.

Roles for the RNA-Binding Protein Rbp2 in Regulating the Circadian Clock.

The cyanobacterial circadian oscillator, consisting of KaiA, KaiB, and KaiC proteins, drives global rhythms of gene expression and compaction of the chromosome and regulates the timing of cell division and natural transformation. While the KaiABC posttranslational oscillator can be reconstituted in vitro, the Kai-based oscillator is subject to several layers of regulation in vivo. Specifically, the oscillator proteins undergo changes in their subcellular localization patterns, where KaiA and KaiC are diffuse throughout the cell during the day and localized as a focus at or near the pole of the cell at night.

Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.

Organic acidemias such as methylmalonic acidemia (MMA) are a group of inborn errors of metabolism that typically arise from defects in the catabolism of amino and fatty acids. Accretion of acyl-CoA species is postulated to underlie disease pathophysiology, but the mechanism(s) remain unknown. Here, we surveyed hepatic explants from patients with MMA and unaffected donors, in parallel with samples from various mouse models of methylmalonyl-CoA mutase deficiency.

Models of care for chronic myeloid leukemia patients during the COVID-19 pandemic in the United Kingdom: Changes in patient attitudes to remote consultations and future implications.

The ongoing COVID-19 pandemic has presented numerous challenges to the provision of patient care within hematology. We undertook a questionnaire-based study investigating the experiences and opinions of patients with chronic myeloid leukemia (CML) in the UK in relation to the different models of follow-up care received during the pandemic. One hundred fifty-four patients completed the online questionnaire.

How to choose a journal and write a cover letter.

Selecting a suitable journal for submitting a manuscript can be a complex and confusing task, and end in disappointment when a paper is rejected quickly for reasons that may not be clear to the author. There have been several articles written offering advice on journal selection, but this article is the most thorough of its kind, using recent evidence to inform the strategies presented. This article provides details on the factors involved in optimal journal selection, giving insights into how to identify suitable journals, why particular criteria are important and ideal methods to approach this task.

Surgery within 6 months of an acute rotator cuff tear significantly improves outcome.

Background: To determine the effect of time to repair on the outcome after an acute rotator cuff tear.

Methods: We performed a retrospective analysis of prospectively collected data on patients presenting with acute rotator cuff tear to our shoulder clinic. Patient-reported outcomes were assessed using the Oxford Shoulder Score, and symptomatic retears were diagnosed by clinical assessment plus imaging.

Outcome following first metatarsophalangeal joint replacement using TOEFIT-PLUS™: A mid term alert.

Background: We aim to evaluate the mid-term results of first metatarsophalangeal joint replacement for hallux rigidus using Toefit-Plus™ in a single surgeon series.

Methods: We prospectively studied the outcomes of 86 toes in 73 patients using the AOFAS-HMI score and radiological follow up. The mean follow up was 33 months (2-72).

Case report of pigmented villonodular synovitis arising from the calcaneocuboid joint in a 12 year old male.

Introduction: Pigmented villonodular synovitis (PVNS) is a benign proliferative disorder of the synovium of unknown aetiology. It usually presents in adults between the ages of 30 and 40 years of age and is rare in the paediatric population. In the literature, there are a total of 43 cases of PVNS affecting the paediatric population and only one case affecting the calcaneocuboid joint.

Early results of first metatarsophalangeal joint replacement using the ToeFit-Plus™ prosthesis.

The aim of the present study was to investigate the outcomes of first metatarsophalangeal replacement for hallux rigidus using the Smith & Nephew ToeFit-Plus™ implant. We assessed the outcomes of 69 first metatarsophalangeal joint replacements using the American Orthopaedic Foot and Ankle Society score preoperatively and annually postoperatively, with retrospective radiologic review. All operations were performed by the same surgeon within 2 centers.

Prediction of intravenous cyclosporine area under the concentration-time curve after allogeneic stem cell transplantation.

Currently, routine monitoring of cyclosporine in patients undergoing allogeneic stem cell transplantation is based on analysis of trough, or C0, predose concentrations. However, recent studies in solid organ transplant recipients have demonstrated that monitoring cyclosporine exposure by analyzing 2-hour postdose concentrations (C2) or area under the concentration-time curve (AUC) may improve clinical outcome. This study investigated the ability of single samples to predict exposure to intravenous cyclosporine in eight patients undergoing allogeneic stem cell transplantation.