Publications by authors named "Duncan M MacKenzie"
E-cigarette vapor exposure in utero causes long-term pulmonary effects in offspring.
Am J Physiol Lung Cell Mol Physiol
December 2022
The in utero environment is sensitive to toxicant exposure, altering the health and growth of the fetus, and thus sensitive to contaminant exposure. Though recent clinical data suggest that e-cigarette use does no further harm to birth outcomes than a nicotine patch, this does not account for the effects of vaping during pregnancy on the long-term health of offspring. Pregnant mice were exposed to: ) e-cigarette vapor with nicotine (PV + Nic 2% Nic in 50:50 propylene glycol: vegetable glycerin), ) e-cigarette vapor without nicotine [PV; (50:50 propylene glycol:vegetable glycerin)], or ) HEPA filtered air (FA).
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- * A study on mice showed that exposure to PM alone or alongside psychological stress resulted in decreased pulmonary function and increased airway hyperreactivity, as well as impaired cardiac function.
- * The findings suggest that short-term exposure to PM and stress negatively impacts respiratory and heart health, highlighting the need for further research on the mechanisms involved, especially for military and occupational settings.