Publications by authors named "Duncan A"

Introduction: Empathy is a fundamental element of high-quality healthcare, though it has been shown to be in decline among medical students and residents. Appeals have therefore been made for the development of evidence-based empathy-enhancing experiential learning and training models. Bringing Art to Life (BATL) is a service-learning program designed within experiential learning pedagogy for psychology and pre-healthcare students.

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Background: Training gaps regarding the diagnosis and management of eating disorders in diverse populations, including racial, ethnic, sexual, and gender minoritized groups, have not been thoroughly examined.

Objective: This study aimed to examine resident physicians' knowledge and attitudes regarding eating disorders in diverse populations, with a focus on areas for improved training and intervention.

Methods: Ninety-two resident physicians in internal medicine, emergency medicine, obstetrics/gynecology, psychiatry, and surgery at an academic center completed an online survey from 12/1/2020-3/1/2021, which comprised multiple choice and vignette-style open-ended questions to assess knowledge and attitudes toward the management and clinical presentations of eating disorders.

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Background: Recent biomedical research has shown the unusual, multisystem effects of coronavirus disease 2019 in humans. One specific sequela of a primary severe acute respiratory syndrome coronavirus 2 infection is the reactivation of latent viruses in various tissues, such as Epstein-Barr virus. Epstein-Barr virus has been identified in many inflammatory gastrointestinal lesions, such as microscopic gastritides and colitides.

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In the past two decades there has been rapid development in the field of computational cardiac models. These have included either (i) mechanical models that assumed simultaneous myocardial activation, or (ii) electromechanical models that assumed time-varying myocardial activation. The influence of these modelling assumptions of myocardial activation on clinically relevant metrics, like myocardial strain, commonly used for validation of cardiac models has yet to be systematically examined, leading to uncertainty over their influence on the predictions of these models.

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Despite the challenges associated with periprocedural imaging, transcatheter tricuspid valve interventions have shown important impact on outcomes. A comprehensive understanding of the anatomy of the right heart and surrounding structures is crucial. One way to optimize these interventions is by identifying the optimal fluoroscopic viewing angles along the S-curve of the tricuspid valve.

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Multi-parous Holstein cows exposed to short day photoperiod (SDPP) of 8 h of light per day during their dry period produced up to 3.2 kg more milk per day compared with cows exposed to long day photoperiod (LDPP) of 16 h of light per day; it is unknown if a similar response would be observed for Jersey cow milk production. The objective of this study was to determine the effect of photoperiod during the dry period on subsequent colostrum and milk production in Holstein and Jersey cattle.

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Background & Aims: Currently, the main treatment for celiac disease (CD) is gluten free diet (GFD). This observational cohort study investigated the impact of CD and 1 year of GFD on gut function and microbiome.

Methods: 36 newly diagnosed patients and 36 healthy volunteers (HVs) were studied at baseline and at 12 months follow up.

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Introduction: Pelvic fractures (PF) occur in up to 9 % of trauma cases, primarily from high-impact events, and are associated with increased morbidity and mortality due to frequent concomitant injuries. Thoracolumbar (TL) spinal fractures, particularly at the T10-L2 junction, are also common in high-energy trauma but are less frequently examined in association with PF. Missed TL fractures can lead to serious neurological deficits.

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Study Objective: To evaluate the associations between high and low intraoperative time-weighted average mean arterial pressures before, during and after cardiopulmonary bypass on postoperative delirium.

Design: Single center retrospective cohort study.

Setting: Operating rooms and postoperative care units.

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Introduction: The cost, high resource demands, and psychological significance of in-person cadaveric labs are barriers to their use. Computer-assisted instruction (CAI) of gross anatomy is widely available as an alternative option. However, student engagement, reflections, and expectations of learning anatomy with CAI instead of in-person labs may influence their learning experience and outcomes.

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Article Synopsis
  • A retrospective cohort study analyzed 260 patients who had spinal decompression surgery to determine factors linked to high-risk daily morphine milligram equivalent (MME) totals, specifically focusing on dosages ≥100 MME/d due to their high overdose risk.
  • The study found that patients classified as "high-risk MME" were significantly younger, had higher body mass indexes (BMIs), and reported more severe preoperative pain, alongside more frequent prior opioid use and receiving ketamine during surgery.
  • The results highlight important independent risk factors for high MME, including younger age, elevated BMIs, preoperative pain scores, and previous opioid use, indicating that monitoring and managing these variables is vital to reducing overdose risks.
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The need for sleep is universal, and the ability to meet this need impacts the quality of life for patients, families, and caregivers. Although substantial progress has been made in treating rare diseases, many patients have unmet medical sleep needs, and current regulatory policy makes it prohibitively difficult to address those needs medically. This opinion reviews the rare disease experience with sleep disorders and explores potential solutions.

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  • The global rise in child obesity is a pressing public health issue, with good sleep hygiene linked to lower body fat in older kids and adults but needing further exploration in younger children.
  • The study observed 48 toddlers to analyze the relationship between sleep patterns and body composition using detailed measurements and adjustments for various factors like age and physical activity.
  • Results showed that when toddlers slept earlier and had consistent sleep routines, their body composition improved, suggesting that establishing healthy sleep habits could help prevent obesity in childhood; more extensive longitudinal studies are needed.
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  • Educators need to understand the factors affecting anatomy learning outcomes for occupational therapy students with varied academic experiences.
  • A study comparing students with and without prior anatomy courses showed that while those with prior experience performed better initially, this difference disappeared by the end of the term.
  • Overall, students struggled more with higher-order thinking assessments, but by the end, those without prior anatomy coursework achieved similar results, indicating they needed time to adjust to the subject.
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Introduction: Traumatic injuries remain a leading cause of mortality across age groups. Despite advancements in medical care, addressing the broader determinants of health is essential. Social determinants of health (SDOH), including socioeconomic factors, play a crucial role in patient outcomes.

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Study Design: Retrospective analysis.

Objective: This study sought to report the long-term outcomes of patients that underwent minimally invasive surgery (MIS) correction for Adolescent Idiopathic Scoliosis (AIS) in terms of radiographic, clinical, and patient-reported outcomes. Furthermore, we examined the learning curve of MIS technique over the course of 13 years.

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The influenza A M2 homotetrameric channel consists of four transmembrane (TM) and four amphipathic helices (AHs). This viral proton channel is suggested to form clusters in the catenoid budding neck areas in raft-like domains of the plasma membrane, resulting in cell membrane scission and viral release. The channel clustering environment is rich in cholesterol.

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Malaria remains a major global health problem. Transmission occurs in 84 countries across five continents, with almost 250 million cases and over 600,000 deaths each year. Primary and secondary care clinicians in the UK need to be alert to the prospect of malaria presenting in returning travellers.

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Leadership is a skill that all surgeons are confronted with in some capacity. Surprisingly in the US most training programs do not offer a structured program in leadership and there certainly are no metrics used to assess leadership competency. As a response to this, at The Society for Clinical Vascular Surgery (SCVS) a panel of leaders in vascular surgery both national and international, along with leadership experts discussed some of the salient issues in this space.

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Individual hosts and populations frequently harbour multiple parasite species simultaneously. Despite their commonness, the consequences of interspecific interactions among parasites for determining infection outcomes are still poorly understood. We review and propose several expectations for multiple infections involving different species.

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Background Selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) use is more common in the plastic surgery population compared to the general population. This study was designed to assess the theoretical effect of SSRIs and SNRIs on platelet function and the potential for increased bleeding risk. This study sought to establish the incidence of postoperative bleeding following routine bilateral breast reduction for patients on SSRIs or SNRIs.

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Background: Pediatric cervical spinal injury (CSI) remains a significant concern following blunt trauma, with mortality rates as high as 48%. Current protocols involve cervical immobilization and clearance through multidetector computed tomography (MDCT) scans, followed by magnetic resonance imaging (MRI) or clinical examination. However, prolonged collar use poses risks, necessitating timely clearance.

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Article Synopsis
  • The text discusses advancements in single-particle cryo-electron microscopy (cryo-EM), specifically focusing on common lines between projection images of molecules.
  • It introduces a new low-rank constraint on a matrix that holds scaled basis vectors, which helps in denoising the common lines and recovering unknown 3D rotations of the images.
  • Furthermore, the paper presents a clustering algorithm to group noisy images into similar communities, effectively addressing the issue of discrete heterogeneity in cryo-EM, with results shown on both synthetic and real datasets.
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Background: A pulse oximetry warning system (POWS) to analyze heart rate and oxygen saturation data and predict risk of sepsis was developed for very low birth weight (VLBW) infants.

Methods: We determined the clinical correlates and positive predictive value (PPV) of a high POWS score in VLBW infants. In a two-NICU retrospective study, we identified times when POWS increased above 6 (POWS spike).

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