Publications by authors named "Dunbiao Wei"
Article Synopsis
- The study focuses on the challenge of treating jellyfish stings and evaluates Sika Deer antler protein (DAP), a traditional Chinese medicine known for its health benefits.
- Proteome analysis revealed 94 proteins in DAP, which has shown the ability to reduce inflammation and oxidative damage in mice exposed to jellyfish venom, improving their survival rates.
- DAP works by targeting specific signaling pathways, such as NF-κB and MAPK, effectively countering jellyfish venom's toxic effects and underscoring the potential of traditional remedies in modern medical treatments.
Article Synopsis
- The study analyzed the toxicity and mechanisms of giant jellyfish venom extracted from tentacles (TE) and nematocysts (NV), identifying 239 and 225 toxin proteins respectively.
- Both extracts caused heart and liver damage through cell death and inflammation, with TE showing greater toxicity in experiments.
- The research also suggested that PACOCF3, a phospholipase A2 inhibitor, significantly improved survival rates in mice, highlighting its potential as an antidote and the importance of extraction methods for studying jellyfish venom.
Current study findings concerning changes in the renin-angiotensin system (RAS) in cases of hyperoxic acute lung injury (HALI) have shown conflicting results. This study aimed to detect the angiotensin II (Ang II) and angiotensin-converting enzyme (ACE) in a rat HALI model. Healthy male Sprague-Dawley rats were randomly assigned into three groups: the control group, HALI group and hyperbaric oxygen preconditioning (HBO₂-PC) group.
View Article and Find Full Text PDFOridonin protects the lung against hyperoxia-induced injury in a mouse model.
Undersea Hyperb Med
December 2017
Hyperoxic acute lung injury (HALI) is caused by prolonged exposure to high oxygen partial pressure. This study was undertaken to investigate the protective effects of oridonin on HALI in a mouse model. Mice were randomly divided into three groups: the control group, HALI group and oridonin (ORI) group.
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