Synthesis, Photophysical Characterization and Evaluation of Biological Properties of C7, a Novel Symmetric -Imidazolium--Heterocycle.

A novel symmetric -imidazolium--heterocycle, called C7, was designed and synthesized in a quick two-step pathway, with the objective to synthesize biologically active supramolecular assembly. The synthesized compound was then analyzed for its photophysical properties, for a potential application in theragnostic (fluorescence) or phototherapy (photodynamic therapy, with the production of reactive oxygen species, such as singlet oxygen O). C7 was thus screened for its biological activity, in particular against important human pathogens of viral origin (respiratory viruses such as adenovirus type 2 and human coronavirus 229E) and of fungal and bacterial origin.

Tris-ACE-α-cyclodextrin tripods: chemistry and metal coordination behaviour.

The synthesis of C3-symmetrical tris-(ACE)-(6,6'-bis-heterocyclyl)-α-cyclodextrins via"one pot" Staudinger-Aza-Wittig (SAW) reaction is described. The spectroscopic properties of their metal coordination compounds were analysed. The spontaneous formation of metallosupramolecular helicates generate strong exciton coupling features enlighten much information on the nature, the geometries of the complexes and their absolute configuration.

Expeditious synthesis of bis-β-cyclodextrinyl-diazacrown-[2]cryptorotaxanes.

An efficient synthesis of original bis-β-cyclodextrin-[2]cryptorotaxanes in moderate to high yields is described. A synthetic approach based on the template-directed self-assembly threading process in aqueous medium gives a structure stabilized exclusively through non-covalent interactions. This procedure reveals a simple and efficient way to prepare highly organized supramolecular receptors from carefully designed subunits.