Natriuretic effect of 4',5-dihydroxy-6,7-methylenedioxyflavonol-3--α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranoside from and studies.

Aqueous leaf extracts of are widely used because of their diuretic, natriuretic, antiurolithiatic, anti-inflammatory and antihypertensive properties. The major component of the extract is the flavonoid 4',5-dihydroxy-6,7-methylenedioxyflavonol-3--α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranoside, but it is not known if this compound is responsible for the biological activity. The objective of this work is to develop effective tools that allow predicting the possible activity of the flavonoid aglycone as an inhibitor of metalloproteases that regulate renal fluid excretion.

The Structure-Antiproliferative Activity Relationship of Pyridine Derivatives.

Pyridine, a compound with a heterocyclic structure, is a key player in medicinal chemistry and drug design. It is widely used as a framework for the design of biologically active molecules and is the second most common heterocycle in FDA-approved drugs. Pyridine is known for its diverse biological activity, including antituberculosis, antitumor, anticoagulant, antiviral, antimalarial, antileishmania, anti-inflammatory, anti-Alzheimer's, antitrypanosomal, antimalarial, vasodilatory, antioxidant, antimicrobial, and antiproliferative effects.