Publications by authors named "Dulce Helena Siqueira e Silva"
Article Synopsis
- Two alkaloids, pterogynine (PGN) and pterogynidine (PGD), from the Brazilian plant Pterogyne nitens were found to induce programmed cell death (apoptosis) in human breast cancer cells.
- The study involved testing these compounds on a specific human breast cancer cell line (ZR-7531) with varying concentrations (0.25-10 mM) and analyzing the results using different assays, including Hoechst and annexin V.
- The findings highlight that while both PGN and PGD effectively kill cancer cells in vitro, the Hoechst assay effectively distinguishes between late apoptosis and necrosis, which the annexin V assay could not.
