[Impact of dronabinol shortage on a population of chronic pain patients: A retrospective observational study].

Objective: A supply shortage of dronabinol occurred between December 2023 and February 2024, forcing chronic pain patients to discontinue this treatment. We assessed the impact of this shortage on patients in our hospital.

Method: A retrospective observational study of patients treated with dronabinol was conducted.

[Use of dronabinol in the treatment of resistant neuropathic pain: Feedback from patients followed in a multidisciplinary pain center].

Introduction: Dronabinol is a drug composed of synthetic delta-9-tetrahydrocannabinol. In France, dronabinol requires a named Temporary Utilisation Authorisation (TUA), for the treatment of refractory neuropathic pain. Few data currently exist concerning its efficacy and tolerance.

Changing trend in referral to secondary care specialist thyroid eye disease clinic following the Amsterdam declaration.

Introduction: Early diagnosis and treatment of thyroid eye disease (TED) improves outcomes. Previous studies have highlighted delays in diagnosis and referral to specialist centres. The Amsterdam declaration (2009) aimed to halve the time from presentation to diagnosis and from diagnosis to referral to a specialist centre in five years.

[Stroke as a therapeutic emergency].

A stroke is an emergency which can be treated as soon as it occurs thanks to thrombolysis. Prognosis is linked to the quality of the technical and relational care ministered by an expert team, aware of the complications and attentive to the needs of the patient.

Towards a model of host-parasite relationships.

The question asked in this article is: "what is a parasite?". Defining a parasite requires defining its host at the same time. A difficult question therefore arises about host-parasite relationships.

In vitro pharmacodynamic parameters of sordarin derivatives in comparison with those of marketed compounds against Pneumocystis carinii isolated from rats.

Pneumocystis carinii pneumonia remains one of the most serious complications of immunosuppressed patients. In this study, the in vitro pharmacodynamic parameters of four sordarin derivatives (GM 191519, GM 237354, GM 193663, and GM 219771) have been evaluated by a new quantitative approach and compared with the commercially available drugs pentamidine, atovaquone, and trimethoprim-sulfamethoxazole (TMP-SMX). In vitro activities and in vivo therapeutic efficacies of sordarin derivatives against P.

Current in vitro culture systems for Pneumocystis.

Although Pneumocystis continuous culture systems have not yet been developed, efficient short-term in vitro methods allowing the production of infectious forms of Pneumocystis can now be employed. The quality of the inoculum will influence the in vitro development of P. carinii.

[Epidural lipomatosis: complication of long-term corticotherapy. Apropos of 2 cases].

Spinal epidural lipomatosis (SEL) is defined as the deposition of loose fat tissue in the epidural space. Two cases are reported which illustrate the main features of this uncommon disease. Most frequently SEL is revealed by neurologic manifestations such as an acute chronic spinal cord compression.

The blood-stages of Plasmodium georgesi, P. gonderi and P. petersi: course of untreated infection in their natural hosts and additional morphological distinctive features.

In the blood of a Cercocebus albigena and of a C. galeritus agilis monkey, the infection with Plasmodium gonderi was found to follow its well-known chronic course; P. georgesi seemed to occur as a relapsing type of malaria parasite; P.

Pneumocystitis carinii organisms from in vitro culture are highly infectious to the nude rat.

Many in vitro systems have been used to cultivate Pneumocystis, but only limited parasite growth has been obtained by different authors. A reliable in vitro system enabling a sustained propagation of Pneumocystis appears to be an important condition for a better definition of the transmission of P. carinii pneumonia.

Kinetic study of antifungal activity of amphotericin B, 5-fluorocytosine and ketoconazole against clinical yeast isolates using liquid-phase turbidimetry.

The fungal growth of clinical yeast isolates and of VW32 clone of Candida albicans were measured in vitro using a liquid-phase turbidimetric system (Bioscreen from Labsystems, France) in defined conditions. Cultures were performed in Shadomy's liquid medium and the fungal growth automatically evaluated every 10 minutes for 24 hours using various concentrations of drugs. The system made it possible to test 200 culture samples in one experiment.

Individual evolution of digestive tract colonization of holoxenic mice by Candida albicans.

Oral administration of various concentrations of Candida albicans to 6-day-old mice established colonization of the digestive tract without mortality. After being weaned (day 21), the development of colonization was studied in a group of mice by daily counting of the number of CFU contained in the feces of each animal. Two features concerning the development of colonization were noted.

[Effect of glucose and nitrogen concentrations on the morphology of Candida albicans and the formation of chlamydospores in synthetic culture media].

Candida albicans was grown in the darkness, at 28 degrees C, in a synthetic medium in which glucose and nitrogen concentrations were varied. Numeric appraisal of the chlamydospore index was possible only in the medium where glucose concentration was 0,08 g/1 or less. When the glucose concentration raised, pseudomycelial thalli bore numerous chlamydospores but sometimes also chains of cells with a dense granular content.

[Chlamydosporulation in "Candida albicans". Course of the morphogenesis; influence of light and sowing density (author's transl)].

Candida albicans is cultivated on rice cream decoction with glucose for chlamydospore production. A developmental stage refered as readiness is recognized. At this stage, the pseudomycelial thalli are able to produce chlamydospore in water without further stimulus by the sporulation medium.

[Chlamydosporulation in "Candida albicans": influence of sowing density and glucose, nitrogen, biotin and mineral salts concentration in rice-cream decoction (author's transl)].

Chlamydospore production by Candida albicans was investigated in rice cream decoction inoculated with a blastospore suspension. Effects of glucose, KH2PO4, (NH4)2SO4 and biotin addition were estimated using a "chlamydospore index" i.e.

[Study of the Sporothrix schenkii (yeast forms) extract. Electrophoretic and immunoelectrophoretic analyses: characterization of enzymatic activities].

An extract from living yeast forms of S. schenckii was prepared. The yeasts originated from a shake culture in B.

[Growth and sexual reproduction of the dermatophyte Arthroderma vanbreuseghemii Takashio (Trichophyton mentagrophytes (Robin blanchard) on a synthetic medium].

A synthetic medium without agar is proposed for the growth and the sexual reprpduction of the dermatophyte Arthroderma vanbreuseghemii (Trichophyton mentagrophytes). The determinations of mycelium dry weight showed that this species grew poorly with only one amino-acid as nitrogen source. A.