Publications by authors named "Duhyung Lee"
Article Synopsis
- This study investigates the distribution of malonate semialdehyde decarboxylases (MSADs) in mycobacterial species by analyzing the genomes of 192 reference strains.
- It was found that MSAD-1 and MSAD-2 are present in about 45.3% of those strains, but many high-virulence strains, notably pathogenic mycobacteria, lack these genes, indicating potential gene loss.
- Further analysis of 255 strains from specific subspecies revealed only 47.4% had MSADs, with some showing mutations, suggesting that MSADs may play a role in mycobacterial evolution and pathogenesis, warranting future research.
For clinical application by dendritic cell (DC)-based cancer immunotherapy, a proper adjuvant system to elicit a strong anticancer immune response is needed. Here, we investigated the potential of chorismate mutase (TBCM, Rv1885c), a putative (TB) virulence factor, as an immunoadjuvant in DC-based tumor immunotherapy. First, we found that TBCM functionally activated DCs by upregulating costimulatory molecules, increasing the secretion of proinflammatory cytokines, enhancing migration and inducing the Th1-type immune response in a dose-dependent manner via TLR4-mediated signaling.
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