[Red cell autoimmunization in a "normal" population. 63 cases (author's transl)].

Anti-red auto-antibodies were found in 69 out of 892 000 blood donors aged between 20 and 60 years, 63 of whom were followed for up to five years. This would suggest an overall incidence of 1 in 13 000 members of a "normal" population. Uncontrolled methyl-dopa treatment could be incriminated in 25% of cases.

[Studies of immunological status, following autologous bone marrow transplantation in man (author's transl)].

Following transplant, circulating immunoglobulin levels fell moderately and remained depressed less than 2 months for IgG, and for variable and longer periods of time for IgM and IgA. Repeated quantitative determinations of antibodies against multiple antigens did not show any decrease in the pretransplant levels. Indeed some patients developed herpes and cytomegalovirus infections to which they responded by a sharp increase in antibody titers.

[Haemolytic anaemia with acanthocytosis and erythrocytic glutathione peroxidase deficiency in severe hepatic diseases. 5 cases (author's transl)].

In 5 patients, haemolysis was intrasplenic. Red cell deformity could be acquired by foreign red cells transfused into the patient. Association of the two abnormalities (acanthocytosis and glutathion peroxydase deficiency) was necessary for the onset of haemolysis.

[Acute leukaemia during pregnancy: favourable course of pregnancy in two patients treated with cytosine arabinoside and anthracyclines (author's transl)].

A report of two cases of acute leukaemia discovered during pregnancy. The first was treated from the 24th week with cytosine arabinoside, daunorubicine and vincristine and then rubidazone. Only an incomplete remission was obtained.

[Non secretary plasma cell leukemia with intracytoplasmic kappa light chains (author's transl)].

A 53 years old female patient with plasma cell leukemia (more than 90% plasma cells in the peripheral blood, and an absolute plasma cell count reaching 147,000/mm3) is described. Electrophoresis and immunoelectrophoresis of serum and concentrated urine did not reveal any paraprotein. No surface immunoglobin has been detected on plasma cell cytoplasmic membranes.

[Lymphomas of the spleen and bone marrow lymphoid nodules (author's transl)].

Many nodular primitive non-Hodgkin's lymphomas of the spleen have a favourable course after splenectomy or chemotherapy. Several observations of this type have been reported in the literature, in which the concept of malignancy is discussed, authors referring to a presarcomatous state or to an idiopathic splenomegaly. The evaluation of the extension of those sarcomas, however, very often show hepatic lesions, and always an increase in the lymphoid marrow nodules.

[Histological study of the bone marrow in 96 cases of Waldenstrom's macroglobulinemia. An evaluation with clinical, haematological and biological data (author's transl)].

Bone marrow biopsy in Waldenstrom's macroglobulinemia shows three types of lesions: lympho-plasmocytic and reticular infiltration, which is the most common, reticular infiltration, and aplastic marrow, more seldom. In all cases the reticulinic network is increased and thickened. These lesions are diffuse or nodular.

[Massive medullary forms of Hodgkin's disease and acute myelofibrosis (author's transl)].

Ten cases of Hodgkin's disease was massive bone marrow invasion. This particular form of the disease is seen either at the outset or in Stage IIIB with a rapid course. It is reflected by a pancytopaenia with poor marrow with little or no superficial nodes.

[A case of Hodgkin's disease with thrombocytopenic purpura, polyneuritis, and cytomegalovirus pneumopathy (author's transl)].

A patient with Hodgkins disease developed successively, a thrombocytopenic purpura, a polyneuristis and a pneumopathy, during a period of remission, and over a period of time lasting 3 months. The authors discuss the possibility of cytomegalovirus being the causative agent.

[Histological lesions of the bone marrow in medullary aplasia. Results of a common protocol on 261 biopsies].

In a cooperative study on bone marrow aplasia, 261 bone marrow biopsies have been examined in triple blind. 13 cases were excluded for technical defect, and 37 cases (17%) excluded for erroneous diagnosis (myelofibrosis or leukemia). It remains 176 first biopsies and 35 second biopsies (10th or 20th month).

[Preservation of hematopoietic stem cells by slow freezing and elimination of the heat of fusion].

Previous experiments, in dogs with fresh bone marrow or bone marrow frozen with a modified freezing system have demonstrated a 100% recovery of frozen stem cells, stored for periods up to 5 months. Five patients, three with drug resistant acute leukemia and two with metastic carcinomas, have been treated with a high dose combination chemotherapy regimen (TACC) followed by reinfusion of marrow cryopreserved with the same modified freezing system. Following the reinfusion of marrow, autologous engraftment was demonstrated on bone marrow aspiration between days 5 and 10.

Histological prognosis in aplastic anaemia.

In the prognosis of aplastic anaemia, bone marrow biopsy displays several data which were unknown by the myelogram: quantitative evaluation of marrow cellularity; vascular and mesenchymatous lesions; extension of lymphoid or histiocytic infiltration. Nevertheless, the confrontation and value of these signs with the previously used prognosis data issued from clinical and haematological observations is still discussed. The lack of a clear understanding of the bone marrow failure delimitation is perhaps the reason of these differences.

Lymphomas of the spleen and bone marrow lymphoid nodules.

Many nodular primitive non-Hodgkin's lymphomas of the spleen have a favourable course after splenectomy or chemotherapy. Several observations of this type have been reported in the literature, in which the concept of malignancy is discussed, authors referring to a presarcomatous state or to an idiopathic splenomegaly. The evaluation of the extension of those sarcomas, however, very often show hepatic lesions, and always an increase in the lymphoid marrow nodules.

[Moschowitz's disease: efficacy of anti-platelet aggregation agents].

In November 1976, a 52 year old woman presented with a Moschowitz syndrome with clinical manifestations of continuous fever at 39 degrees and a transient Wernicke type aphasia. Laboratory findings included schizocytosis, a peripheral thrombocytopaenia and functional renal insufficiency. The ethanol tests was positive but there was no frank defibrination syndrome.

[Gastro-intestinal involvement in non Hodgkin's lymphomas, 31 cases (author's transl)].

Gastro-intestinal involvement is a distinctive feature of non-Hodgkin's lymphomas. 31 cases are reported among 200 cases on NHL observed between 1960 and 1976. Multiple involvement appeared in 61%; a diffuse histological pattern is frequent (67%).