Publications by authors named "Duha Awad"
Elevated expression of CD47 in some cancers is associated with poor survival related to its function as an innate immune checkpoint when expressed on tumor cells. In contrast, elevated CD47 expression in cutaneous melanomas is associated with improved survival. Previous studies implicated protective functions of CD47 expressed by immune cells in the melanoma tumor microenvironment.
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- Autophagy is a process that helps cells recycle components and defend against bacterial infections; this study focuses on how soluble uric acid affects these processes.
- Researchers used two types of macrophage cells (one with uricase and one without) to see how soluble uric acid interacts with bacterial infections and inflammatory responses.
- Findings show that soluble uric acid boosts autophagy in infected macrophages and lowers levels of IL-1β, which is linked to inflammation, while not significantly impacting the release of TNFα.