Publications by authors named "Dufton M Mwaengo"
Article Synopsis
- There is a significant need for locally-derived clinical laboratory reference ranges for healthy Africans in sub-Saharan Africa, as using North American and European standards may not be applicable due to notable differences in health indicators.
- A study involving 298 HIV-negative individuals aged 13-34 from western Kenya revealed that hematological and biochemistry values differ from U.S. reference ranges, with lower levels of several key parameters and gender/age variations observed in health metrics.
- The findings highlight that 40% of the healthy participants were classified as having abnormal laboratory parameters using U.S. grading, suggesting that region-specific reference values are necessary for accurate clinical assessment and participation eligibility in trials.
Complete sequencing of p54-gene from 67 European, American, and West and East African Swine Fever virus (ASFV) isolates revealed that West African and European ASFV isolates classified within the predominant Genotype I according to partial sequencing of p72 were discriminated into four major sub-types on the basis of their p54 sequences. This highlighted the value of p54 gene sequencing as an additional, intermediate-resolution, molecular epidemiological tool for typing of ASFV viruses. We further evaluated p54-based genotyping, in combination with partial sequences of two other genes, for determining the genetic relationships and origin of viruses responsible for disease outbreaks in Kenya.
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