Ammonia synthesis via an engineered nitrogenase assembly pathway in .

Heterologous expression of nitrogenase has been actively pursued because of the far-reaching impact of this enzyme on agriculture, energy and environment. Yet, isolation of an active two-component, metallocentre-containing nitrogenase from a non-diazotrophic host has yet to be accomplished. Here, we report the heterologous synthesis of an active Mo-nitrogenase by combining genes from and in .

Targeting early proximal-rod component substrate FlgB to FlhB for flagellar-type III secretion in Salmonella.

The Salmonella flagellar secretion apparatus is a member of the type III secretion (T3S) family of export systems in bacteria. After completion of the flagellar motor structure, the hook-basal body (HBB), the flagellar T3S system undergoes a switch from early to late substrate secretion, which results in the expression and assembly of the external, filament propeller-like structure. In order to characterize early substrate secretion-signals in the flagellar T3S system, the FlgB, and FlgC components of the flagellar rod, which acts as the drive-shaft within the HBB, were subject to deletion mutagenesis to identify regions of these proteins that were important for secretion.

Statistical finite elements for misspecified models.

We present a statistical finite element method for nonlinear, time-dependent phenomena, illustrated in the context of nonlinear internal waves (solitons). We take a Bayesian approach and leverage the finite element method to cast the statistical problem as a nonlinear Gaussian state-space model, updating the solution, in receipt of data, in a filtering framework. The method is applicable to problems across science and engineering for which finite element methods are appropriate.

Infections of the Hepatobiliary System.

Hepatobiliary infections account for a small but clinically important proportion of emergency department presentations. They present a clinical challenge due to the broad range of imaging characteristics on presentation. Recognition of complications is imperative to drive appropriate patient care and resource utilization to avoid diagnostic pitfalls and avert adverse patient outcomes.

Radiologic Imaging of Bowel Infections.

Although radiologic imaging of bowel infections is often a precursor to definitive diagnosis by endoscopy, biopsy, or stool cultures, imaging can provide critical information for diagnosis and management. Many infectious entities such as viral, bacterial, and parasitic infections can be discovered on imaging. Furthermore, imaging characterizes the extent of infection, involvement of specific bowel segments, and presence of complications in the abdomen.

Not enough is done to cut risk of death after cardiac arrest.

How much is being done to cut the number of people who die after cardiac arrests in public places? Not enough, says a group of cardiac experts and campaigners on the Out of Hospital Cardiac Arrest (OHCA) steering group.

Young people's changing demands for emergency services.

A ten-year study has highlighted some eye-opening statistics concerning children and emergency care: significantly more children are now being admitted for jaundice, acute bronchitis, acute and chronic tonsillitis, and viral infections.

Five-year plan will revamp neonatal services in Scotland.

The Scottish Government is considering recommendations for a revamp of neonatal services - including creating three specialist neonatal intensive care units in the next five years.

Seacole campaigner made a dame in honours list.

A trailblazing nurse who was a leading figure in the Mary Seacole statue campaign has been made a dame in the new year's honours.

Leading clinic reports 40% drop in HIV diagnoses.

A nurse-led sexual health clinic has reported a 'significant' 40% fall in HIV diagnoses.

The NHS needs you - and it has to work harder than ever to keep you.

The number of employers in the NHS paying extra to attract or retain staff in England is falling.

Nathaniel Hodges (1629-1688): Plague doctor.

Nathaniel Hodges was the son of Thomas Hodges (1605-1672), an influential Anglican preacher and reformer with strong connections in the political life of Carolingian London. Educated at Westminster School, Trinity College Cambridge and Christ Church College, Oxford, Nathaniel established himself as a physician in Walbrook Ward in the City of London. Prominent as one of a handful of medical men who remained in London during the time of the Great Plague of 1665, he wrote the definitive work on the outbreak.

Virtual children's ward brings the hospital into the home.

LEAD NURSE Zoe Tribble believes she manages a unique service. She oversees four other nurses in a team of outreach workers who deliver a 'virtual ward' service to babies and children in their own homes who would traditionally have had to stay in hospital. There are other teams that do a similar job, but none manage it from 7am-11pm every day of the year and can complete three visits a day to patients, Ms Tribble argues.

Providing health care from army camp to civvy street.

NOT MANY nurses have to learn to use a pistol and rifle, but Elizabeth Shillito did. It was part of training during her 22-year career as a nurse in the Royal Air Force (RAF), which has taken her all over the world, including to the war zones of Iraq, Kuwait and Afghanistan.

Academics draw up ten-point plan for pre-degree nursing scholarship.

A ten-point plan for a pre-degree 'scholarship' has been drawn up by academics in Scotland in a bid to give school pupils a chance to determine whether to pursue a nursing career.