Use of Reporting Recommendation Intended for Pharmaceutical Risk Minimisation Evaluation Studies (RIMES) Checklist in Risk Minimisation/Mitigation Studies: A Review and Survey.

Introduction: The Reporting Recommendation Intended for Pharmaceutical Risk Minimisation Evaluation Studies (RIMES) checklist is endorsed by the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP) and is tailored for studies assessing Risk Minimisation Measures and Risk Evaluation and Mitigation Strategy (RMM/REMS) effectiveness; however, its awareness and usage remain unknown. We evaluated the implementation of the RIMES checklist in RMM/REMS effectiveness studies registered in the EUPAS register during 01 December 2017- 01 January 2024. Furthermore, the awareness and utilization of the RIMES checklist among researchers conducting RMM/REMS effectiveness studies was assessed.

Solubility, complexation and thermodynamics of the Tc(IV)-isosaccharinic acid system: Trends in the M(IV) series.

Isosaccharinic acid (HISA, or ISA in its deprotonated form) is the main degradation product of cellulose under alkaline conditions. It can form strong complexes with radionuclides and other toxic metal ions, eventually enhancing their mobility in the context of nuclear waste repositories and other environmental systems. Tc is a redox-sensitive, long-lived fission product produced in high yield in nuclear reactors.

Big Data in Health Care: An Interprofessional Course.

Background: The widespread adoption of the electronic health record (EHR) has resulted in vast repositories of EHR big data that are being used to identify patterns and correlations that translate into data-informed health care decision making.

Problem: Health care professionals need the skills necessary to navigate a digitized, data-rich health care environment as big data plays an increasingly integral role in health care.

Approach: Faculty incorporated the concept of big data in an asynchronous online course allowing an interprofessional mix of students to analyze EHR big data on over a million patients.

Technetium Complexation with Multidentate Carboxylate-Containing Ligands: Trends in Redox and Solubility Phenomena.

The chemistry of technetium ((Tc) = 2.11 × 10 years) is of particular importance in the context of nuclear waste disposal and historic contaminated sites. Polycarboxylate ligands may be present in some sites and are potentially capable of strong complexing interactions, thus increasing the solubility and mobility of Tc under environmentally relevant conditions.

Role of age and sex on dual tasking using a treadmill desk while performing cognitive tests.

Background: Treadmill desks have been used extensively to increase physical activity and decrease sedentary time in the work environment. However, dual tasking, such as simultaneously walking and performing a cognitive task, may result in diminished performance in one or both tasks.

Research Question: Do age and sex impact ability to dual task while using a treadmill desk at a preferred walking speed?.

A Combined Study of Tc Redox Speciation in Complex Aqueous Systems: Wet-Chemistry, Tc K-/L-Edge X-ray Absorption Fine Structure, and Ab Initio Calculations.

The combination of wet-chemistry experiments (measurements of pH, , and [Tc]) and advanced spectroscopic techniques (K- and L-edge X-ray absorption fine structure spectroscopy) confirms the formation of a very stable Tc(V)-gluconate complex under anoxic conditions. In the presence of gluconate and an excess of Sn(II) (at pe + pH ≈ 2), technetium forms a very stable Tc(IV)-gluconate complex significantly enhancing the solubility defined by TcO(s) in hyperalkaline gluconate-free systems. A new setup for "tender" X-ray spectroscopy (spectral range, ∼2-5 keV) in transmission or total fluorescence yield detection mode based on a He flow cell has been developed at the INE Beamline for radionuclide science (KIT light source).

Is pregnancy brain real? Comparison of dual task cost during overground walking in pregnant versus control women.

Background: Many pregnant women report that their memory is impaired compared to non-pregnancy, but results of studies of cognitive abilities are mixed. The effect of pregnancy on dual tasking, or performance of two tasks simultaneously, has not been studied, however.

Research Question: What is the effect of walking overground at a self-selected speed while also performing a cognitive task on gait and cognitive performance during 3rd trimester of pregnancy compared to non-pregnant controls?

Methods: A total of n = 22 3rd trimester pregnant women (mean 33.

Physical and Cognitive Performance During Upper-Extremity Versus Full-Body Exercise Under Dual Tasking Conditions.

The purpose of this study was to investigate physical and cognitive performance during dual task conditions of upper-extremity (UE) or full-body (FB) rowing exercise. In a crossover counterbalanced design, college-aged male and female participants completed five conditions: (a) Sitting, (b) Single task UE rowing, (c) Single task FB rowing, (d) Dual task UE rowing, and (e) Dual task FB rowing. For single task UE and FB rowing conditions, participants were asked to row as hard as possible.

Predicting delivery of a small-for-gestational-age infant and adverse perinatal outcome in women with suspected pre-eclampsia.

Objective: To evaluate the test performance of 47 biomarkers and ultrasound parameters for the prediction of delivery of a small-for-gestational-age (SGA) infant and adverse perinatal outcome in women presenting with suspected pre-eclampsia.

Methods: This was a prospective, multicenter observational study in which 47 biomarkers and ultrasound parameters were measured in 397 women with a singleton pregnancy presenting with suspected preterm pre-eclampsia between 20 + 0 and 36 + 6 weeks' gestation, with the objective of evaluating them as predictors of subsequent delivery of a SGA infant and adverse perinatal outcome. Women with confirmed pre-eclampsia at enrollment were excluded.

Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes.

Germ line mutations of the gene encoding the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase () cause a hereditary cancer syndrome known as hereditary leiomyomatosis and renal cell cancer (HLRCC). HLRCC-associated tumors harbor biallelic inactivation that results in the accumulation of the TCA cycle metabolite fumarate. Although it is known that fumarate accumulation can alter cellular signaling, if and how fumarate confers a growth advantage remain unclear.

On the Gold-Catalyzed Generation of Vinyl Cations from 1,5-Diynes.

Conjugated 1,5-diynes bearing two aromatic units at the alkyne termini were converted in the presence of a gold catalyst. Under mild conditions, aryl-substituted dibenzopentalenes were generated. Calculations predict that aurated vinyl cations are key intermediates of the reaction.

Placental Growth Factor (PlGF) in Women with Suspected Pre-Eclampsia Prior to 35 Weeks' Gestation: A Budget Impact Analysis.

Objective: To model the resource implications of placental growth factor (PlGF) testing in women with suspected pre-eclampsia prior to 35 weeks' gestation as part of a management algorithm, compared with current practice.

Methods: Data on resource use from 132 women with suspected pre-eclampsia prior to 35 weeks' gestation, enrolled in a prospective observational cohort study evaluating PlGF measurement within antenatal assessment units within two UK consultant-led maternity units was extracted by case note review. A decision analytic model was developed using these data to establish the budget impact of managing women with suspected pre-eclampsia for two weeks from the date of PlGF testing, using a clinical management algorithm and reference cost tariffs.

Diagnostic Biomarkers in Women With Suspected Preeclampsia in a Prospective Multicenter Study.

Objective: To evaluate 47 biomarkers (selected from the current medical literature), in isolation or in combination with placental growth factor (PlGF), to determine the need for delivery within 14 days, in women presenting with suspected preterm preeclampsia.

Methods: In a prospective, multicenter observational study, 47 biomarkers were measured in 423 women presenting with suspected preterm preeclampsia (in two prespecified groups: group 1 at less than 35 weeks of gestation and group 2 presenting between 35 0/7 and 36 6/7 weeks of gestation) to evaluate their ability to determine the primary endpoint: preeclampsia requiring delivery within 14 days. Using factor analysis and stepwise logistic regression, we sought one or more additional biomarkers for optimal determination of the primary endpoint.

Anti-VEGF therapies in the treatment of choroidal neovascularisation secondary to non-age-related macular degeneration: a systematic review.

Objectives: The aim of this study is to systematically review the evidence for anti-vascular endothelial growth factor (VEGF) therapy in choroidal neovascularisation secondary to conditions other than age-related macular degeneration.

Data Sources: MEDLINE, MEDLINE in-process, EMBASE and CENTRAL databases and conference abstracts were searched (from inception to Jan 2014).

Study Eligibility Criteria, Participants And Interventions: Randomised and non-randomised comparative studies with follow-up of at least 6 months were included and were used to assess clinical effectiveness.

Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter study.

Background: Hypertensive disorders of pregnancy are a major contributor to death and disability for pregnant women and their infants. The diagnosis of preeclampsia by using blood pressure and proteinuria is of limited use because they are tertiary, downstream features of the disease. Placental growth factor (PlGF) is an angiogenic factor, a secondary marker of associated placental dysfunction in preeclampsia, with known low plasma concentrations in the disease.

PP051. Budget impact analysis of maternal plasma PIGF concentrations in women with suspected pre-eclampsia: The potential for improved health service usage.

Introduction: Existing methods of assessing women with suspected pre-eclampsia are expensive and labour intensive, yet perform poorly.

Objectives And Methods: The PELICAN multi-centre observational cohort study demonstrated that PlGF predicts need for delivery for pre-eclampsia within 14 days. We constructed a decision analytical model using outcome data from 100 women comparing resource use by final diagnosis and PlGF level.

Use of vitamin C and E to prevent preeclampsia.

A review of the evidence exploring the effects of vitamin supplementation on pre-eclampsia and its co-morbidities.

Genomics and public health practice: a survey of nurses in local health departments in North Carolina.

In order to examine the extent to which current public health practices incorporate information about genetic susceptibilities potentially obtained by a comprehensive family history, public health nurses in North Carolina were surveyed to assess the extent to which this information is routinely collected. In addition, we measured nurses' awareness of the Centers for Disease Control and Prevention's Genomic Competencies and assessed training needs related to genomics. A self-administered survey was distributed to all public health nurse supervisors, directors, consultants as well as Breast and Cervical Cancer Coordination Program managers in North Carolina.

The effect of medical education on the attitudes of medical students towards disabled people.

The negative attitudes of society towards disability and the resulting prejudicial behaviour affects the lives of disabled people. One of the declared aims of the Faculty of Medicine of the University of Southampton is to improve attitudes. Hence, an attempt has been made to assess differences in the attitudes held by first- and fourth-year medical students, senior house officers and members of the general public towards disabled people.