Publications by authors named "Duchateau J"

Background: Cardioneuroablation (CNA) targets ganglionated plexus (GP) to treat neurally-mediated syncope, yet a standardized GP identification method is lacking. Post-processing of cardiac computed tomography (CT) identifies epicardial fat thus allowing for fat pad identification. While CT-guided CNA's feasibility is documented, data about GP anatomy and comprehensive evaluations of GP targeting methods remain scarce.

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  • The exact causes of common atrial flutter are not fully understood, particularly regarding arrhythmia triggers and the impact of slow-conducting heart tissue.
  • A detailed electrophysiological study was conducted on a patient to investigate how this arrhythmia starts and is maintained, utilizing techniques like electro-anatomical mapping.
  • The study found that common atrial flutter begins with a unidirectional conduction block at the septal cavo-tricuspid isthmus, resulting in a counter-clockwise activation pattern and stabilization near specific heart regions, without any slowing of conduction.
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Currently, pulmonary vein isolation (PVI) is the gold standard in catheter ablation for atrial fibrillation (AF). However, PVI alone may be insufficient in the management of persistent AF, and complementary methods are being explored. One such method takes an anatomical approach-improving both its success rate and lesion durability may lead to improved treatment outcomes.

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Mexiletine (NaMuscla™) is indicated for the symptomatic treatment of myotonia in adults with non-dystrophic myotonia. A cardiac assessment is required as mexiletine may have a pro-arrhythmic effect. Long-term safety data supporting the use of mexiletine in patients with non-dystrophic myotonia combined with the extensive clinical experience of an expert group resulted in creation of an algorithm for cardiac monitoring of patients treated with mexiletine.

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Background: Idiopathic ventricular fibrillation (IVF) can be associated with undetected distinct conditions such as microstructural cardiomyopathic alterations (MiCM) or Purkinje (Purk) activities with structurally normal hearts.

Objectives: This study sought to evaluate the characteristics of recurrent VF recorded on implantable defibrillator electrograms, associated with these substrates.

Methods: This was a multicenter collaboration study.

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Background: Little is known about left ventricular (LV) sequences of contraction and electrical activation in hypertrophic cardiomyopathy (HCM). A better understanding of the underlying relation between mechanical and electrical activation may allow the identification of predictive response criteria to right ventricular DDD pacing in obstructive patients.

Objective: To describe LV mechanical and electrical activation sequences in HCM patients compared to controls.

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The aim of our study was to compare the effects of two different plyometric training programs (targeting knee extensors or plantar flexors) on jump height and strength of leg muscles. Twenty-nine male basketball players were assigned to the knee-flexed (KF), knee-extended (KE), or control groups. In addition to regular training, the KF group performed plyometric jumps (10 sets of 10 jumps, 3 sessions/week, 4 weeks) from 50 cm boxes with the knee flexed (90°-120°), whereas the KE group performed the jumps from 30 cm boxes with the knee much more extended (130°-170°).

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In France, mexiletine - a class I antiarrhythmic drug - can be prescribed for the symptomatic treatment of myotonia of the skeletal muscles in adult patients with myotonic dystrophy under a compassionate use programme. Mexiletine is used according to its summary of product characteristics, which describes its use for myotonia treatment in adult patients with non-dystrophic myotonia, a different neuromuscular condition without cardiac involvement. A cardiac assessment is required prior to initiation and throughout treatment due to potential proarrhythmic effects.

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Sustainability in healthcare, particularly within the domain of cardiac electrophysiology, assumes paramount importance for the near future. The escalating environmental constraints encountered necessitate a proactive approach. This position paper aims to raise awareness among physicians, spark critical inquiry and identify potential solutions to enhance the sustainability of our practice.

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  • The study aims to differentiate atypical atrioventricular nodal reentrant tachycardia (AVNRT) from orthodromic reciprocating tachycardia using a new method called the "local VA index," based on coronary sinus signals during arrhythmia.
  • The retrospective analysis involved 75 patients with 37 diagnosed with AVRT and 38 with AVNRT, revealing significant differences in specific measurements between the two groups.
  • The local VA index showed potential as an effective tool for distinguishing these arrhythmias, with a suggested threshold of 40 ms, while also highlighting limitations in traditional pacing methods due to variability in patient results.
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The aim of the study was to assess neuromuscular changes during an intermittent fatiguing task designed to replicate fundamental actions and ergonomics of road race motorcycling. Twenty-eight participants repeated a sequence of submaximal brake-pulling and gas throttle actions, interspaced by one maximal brake-pulling, until failure. During the submaximal brake-pulling actions performed at 30% MVC, force fluctuations, surface EMG, maximal M-wave (M) and H-reflex were measured in the flexor digitorum superficialis.

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  • The study focuses on the unique structure of the right ventricular insertion point (RVIP) in the human heart, which has been less examined compared to the left ventricle.
  • Researchers used advanced imaging techniques on sheep and human hearts to analyze cardiomyocyte organization and identified a distinct triangular region at the RVIP characterized by a sudden change in cell orientation.
  • Findings showed that this region affects the electrical activity of the heart, leading to delayed activation times and altered ECG signals, indicating its importance in understanding heart function and potential arrhythmias.
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Background: There are few data on ventricular fibrillation (VF) initiation in patients with inferolateral J waves.

Objectives: This multicenter study investigated the characteristics of triggers initiating spontaneous VF in inferolateral J-wave syndrome.

Methods: A total of 31 patients (age 37 ± 14 years, 24 male) with spontaneous VF episodes associated with inferolateral J waves were evaluated to determine the origin and characteristics of triggers.

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  • Electrophysiological mapping of ventricular tachycardia (VT) is difficult and not very reliable, prompting the need for better simulation methods of post-infarction VT.
  • A new method using computed tomography (CT) to create personalized models was developed, allowing quick simulations of heart activity related to VT in patients set for ablation therapy.
  • The study successfully simulated various VT patterns in most patients, with several simulations matching actual clinical recordings, demonstrating the potential for personalized, rapid modeling of heart rhythms.
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  • The study investigates the relationship between abnormal atrial potentials (AAPs) and reentrant atrial tachycardia (AT), focusing on how AAPs can indicate areas of slow conduction that support AT circuits.
  • Analysis of 123 ATs in 104 patients shows a significant overlap (93±13%) between AAP areas during sinus rhythm and regions of slow conduction during AT, with variations in AAP distribution based on the type of AT.
  • Findings suggest that AAPs may help identify AT circuit characteristics, particularly in challenging mapping situations, with localized-reentrant ATs having smaller AAP areas compared to macro-reentrant ATs.
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  • Substrate abnormalities can change how atrial tachycardias (ATs) activate, affecting their wave patterns on electrocardiograms.
  • This study examined high-density activation maps of 126 ATs to determine factors influencing periods of no electrical activity (isoelectric intervals) during these complex activation patterns.
  • Results showed that smaller activated areas and larger low-voltage regions were significant predictors of these isoelectric intervals, with specific metrics indicating a strong ability to predict the presence of these intervals during atrial tachycardias.
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Rapid force production and its transmission to the skeleton are important factors in movements that involve the stretch-shortening cycle. Plyometric exercises are known to augment this cycle and thereby improve the neuromechanical function of the muscle. However, the training exercises that maximize translation of these gains to sports performance are not well defined.

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