Fluorescent nanodiamond-based spin-enhanced lateral flow immunoassay for detection of SARS-CoV-2 nucleocapsid protein and spike protein from different variants.

SARS-CoV-2 viruses, responsible for the COVID-19 pandemic, continues to evolve into new mutations, which poses a significant threat to public health. Current testing methods have some limitations, such as long turnaround times, high costs, and professional laboratory requirements. In this report, the novel Spin-Enhanced Lateral Flow Immunoassay (SELFIA) platform and fluorescent nanodiamond (FND) reporter were utilized for the rapid detection of SARS-CoV-2 nucleocapsid and spike antigens from different variants, including wild-type (Wuhan-1), Alpha (B.

Antimicrobial sponge prepared by hydrophobically modified chitosan for bacteria removal.

Hydrophobically modified chitosan (HMCS) prepared by reacting chitosan with dodecyl aldehyde can generate very stable foam when dissolved in mild acidic condition under vigorous mechanical stirring. A durable and lightweight (density of 32 mg/ml) sponge was obtained by freeze-drying the stably formed HMCS foam. In addition to the cationic nature of chitosan, the grafted C alkyl chains were also able to help HMCS sponge for capturing E.

Cells capture and antimicrobial effect of hydrophobically modified chitosan coating on Escherichia coli.

Hydrophobically modified chitosan (HMCS), prepared by reacting alkyl aldehyde with chitosan was demonstrated to be an effective antimicrobial and transparent coating. The grafted alkyl chains exist as protruded hydrophobic tails on the HMCS coating surface. In contact with E.

Silver deposited carboxymethyl chitosan-grafted magnetic nanoparticles as dual action deliverable antimicrobial materials.

Carboxymethyl chitosan (CMCS) was known to have a much better antimicrobial activity than chitosan due to the increased cationic -NH groups resulted from the intra- and intermolecular interactions between the carboxyl and amino groups. CMCS was grafted onto the surface of silica coated magnetic nanoparticles (MNPs) to obtain magnetically retrievable and deliverable antimicrobial nanoparticles (MNPs@CMCS). The presence of carboxylate groups in CMCS not only enhanced antimicrobial activity but also enabled Ag ions chelating ability to induce the in situ formation of Ag nanoparticles (AgNPs).

Bactericidal magnetic nanoparticles with iodine loaded on surface grafted poly(N-vinylpyrrolidone).

Bactericidal magnetic nanoparticles were prepared by complexing iodine with poly(N-vinylpyrrolidone) (PVP) grown at the surface of silica coated magnetic nanoparticles (MNPs) via surface-initiated atom transfer radical polymerization (SI-ATRP). Approximately, 10 mg of iodine could be loaded onto one gram of the PVP-grafted MNPs to form bactericidal MNPs@PVP-I. At a concentration of 5 g L, MNPs@PVP-I could achieve 100% bactericidal rate for both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus with a concentration of ∼1 × 10 CFU mL within 3 min.