Two New Steroidal Saponins with Potential Anti-Inflammatory Effects from the Aerial Parts of Markgr.

Markgr., a member of the Gnetaceae family, is distributed in Vietnam. This plant remains a botanical enigma with an unexplored diversity of chemical constituents and pharmacological effects.

Premise setting for sustainable developing adsorption in environmental remediation using graphitic carbon nitride@agar-derived porous carbon composite.

In the adsorption process for wastewater treatment, the adsorbent plays an important role. A composite adsorptive material composed of graphitic carbon nitride and agar-derived porous carbon (CNPC) was fabricated from simple precursors (melamine, thiourea, and agar) and through a facile procedure with different melamine and thiourea ratios. Characterization of CNPC proved a successful formation of a porous structure consisting of mesopores and macropores, wherein CNPC holds distinctive electrochemical (lowered resistance and higher specific capacity) and photochemical properties (lowered bandgap to 2.

A study on a broadband photodetector based on hybrid 2D copper oxide/reduced graphene oxide.

These days, photodetectors are a crucial part of optoelectronic devices, ranging from environmental monitoring to international communication systems. Therefore, fabricating these devices at a low cost but obtaining high sensitivity in a wide range of wavelengths is of great interest. This report introduces a simple solution-processed hybrid 2D structure of CuO and rGO for broadband photodetector applications.

Fabrication of a Reflective Optical Imaging Device for Early Detection of Breast Cancer.

This work presented the design and fabrication of a blood vessel and breast tumor detection device (BKA-06) based on optical energy spectroscopy. The BKA-06 device uses red-to-near-infrared light-emitting diodes that allow physicians or physicians to visualize blood vessels and surface structures such as breast tumors with the naked eye. The device consists of a built-in current control circuit to have the appropriate brightness (maximum illuminance of 98,592 lux) for the examination of superficial tumors deep under the skin, with a scan time of 3-5 min.

Performance and feasibility of reactive surveillance and response strategies for malaria elimination in Vietnam: a mixed-methods study.

Background: To enhance malaria elimination, Vietnam adopted a Reactive Surveillance and Response (RASR) Strategy in which malaria case notification and investigation must be completed within 2 days followed by a focus investigation within 7 days. The nationwide performance of Vietnam's RASR strategy has yet to be evaluated. This study aims to evaluate the performance and feasibility of RASR in Vietnam, thereby providing recommendations for improved RASR.

Developing low-cost nanohybrids of ZnO nanorods and multi-shaped silver nanoparticles for broadband photodetectors.

Photodetectors are essential elements for various applications like fiber optic communication systems, biomedical imaging, and so on. Thus, improving the performance and reducing the material costs of photodetectors would act as a motivation toward the future advancement of those applications. This study introduces the development of a nanohybrid of zinc oxide nanorods (ZnONRs) and multi-shaped silver nanoparticles MAgNPs through a simple solution process; in which ZnONRs are hybridized with MAgNPs to enable visible absorption through the surface plasmon resonance (SPR) effect.

Readmission and Mortality After Hospitalization With Acute Kidney Injury.

Rationale & Objective: Acute kidney injury (AKI) carries high rates of morbidity and mortality. This study quantified various short- and long-term outcomes after hospitalization with AKI.

Study Design: Retrospective propensity score (PS)-matched cohort study.

Alpha-Glucosidase Inhibitory Activity of Saponins Isolated from Hance.

Species belonging to the (Asteraceae), the largest genus in the tribe Vernonieae (consisting of about 1,000 species), are widely used in food and medicine. These plants are rich sources of bioactive sesquiterpene lactones and steroid saponins, likely including many as yet undiscovered chemical components. A phytochemical investigation resulted in the separation of three new stigmastane-type steroidal saponins (1 - 3), designated as vernogratiosides A-C, from whole plants of .

Physachenolide C is a Potent, Selective BET Inhibitor.

A pulldown using a biotinylated natural product of interest in the 17β-hydroxywithanolide (17-BHW) class, physachenolide C (PCC), identified the bromodomain and extra-terminal domain (BET) family of proteins (BRD2, BRD3, and BRD4), readers of acetyl-lysine modifications and regulators of gene transcription, as potential cellular targets. BROMOscan bromodomain profiling and biochemical assays support PCC as a BET inhibitor with increased selectivity for bromodomain (BD)-1 of BRD3 and BRD4, and X-ray crystallography and NMR studies uncovered specific contacts that underlie the potency and selectivity of PCC toward BRD3-BD1 over BRD3-BD2. PCC also displays characteristics of a molecular glue, facilitating proteasome-mediated degradation of BRD3 and BRD4.

eGAC3D: enhancing depth adaptive convolution and depth estimation for monocular 3D object pose detection.

Many alternative approaches for 3D object detection using a singular camera have been studied instead of leveraging high-precision 3D LiDAR sensors incurring a prohibitive cost. Recently, we proposed a novel approach for 3D object detection by employing a ground plane model that utilizes geometric constraints named GAC3D to improve the results of the deep-based detector. GAC3D adopts an adaptive depth convolution to replace the traditional 2D convolution to deal with the divergent context of the image's feature, leading to a significant improvement in both training convergence and testing accuracy on the KITTI 3D object detection benchmark.

Allosteric differences dictate GroEL complementation of E. coli.

GroES/GroEL is the only bacterial chaperone essential under all conditions, making it a potential antibiotic target. Rationally targeting ESKAPE GroES/GroEL as an antibiotic strategy necessitates studying their structure and function. Herein, we outline the structural similarities between Escherichia coli and ESKAPE GroES/GroEL and identify significant differences in intra- and inter-ring cooperativity, required in the refolding cycle of client polypeptides.

GAC3D: improving monocular 3D object detection with ground-guide model and adaptive convolution.

Monocular 3D object detection has recently become prevalent in autonomous driving and navigation applications due to its cost-efficiency and easy-to-embed to existent vehicles. The most challenging task in monocular vision is to estimate a reliable object's location cause of the lack of depth information in RGB images. Many methods tackle this ill-posed problem by directly regressing the object's depth or take the depth map as a supplement input to enhance the model's results.

Prognosis value of revised Baux score among burn patients in developing country.

The aims of this study was to determine prognosis value of revised Baux score for burn patients in developing country. A retrospective study was conducted on all burn hospitalized patients at National Burn Hospital, Hanoi, Viet Nam during a period from 01/1/2015 to 31/12/2019. Collected criteria included age, burn extent, inhalation injury, death or survive, Baux and revised Baux score of each patients.

Trends and risk markers of student hazardous drinking: a comparative analysis using longitudinally linked datasets in a public university.

This study compares the incidence and risk-markers of student alcohol intoxication-related emergency department (ED) visits and alcohol-related incidents reported to student affairs. Enrollment data were linked to ED visits with alcohol intoxication and to alcohol-related incidents reported to campus authorities within one year following the first (index) annual enrollment. Incidence, annual trends and associated risk markers were analyzed.

Epidemiology of pediatric buprenorphine and methadone exposures reported to the poison centers.

Background: Buprenorphine prescriptions have increased dramatically within the United States, whereas methadone continues to be used widely. We investigated the trends and characteristics of buprenorphine and methadone exposures in the pediatric population.

Methods: We identified pediatric exposures to buprenorphine and methadone using the National Poison Data System from 2013 to 2016.

Influence of pre-existing medical condition and predicting value of modified Elixhauser comorbidity index on outcome of burn patients.

Objectives: To evaluate the impact of comorbidity and predicting value of the modified Elixhauser comorbidity index score on the outcome of burn patients.

Methods: A retrospective study was conducted on 5480 patients admitted during 24 h after burn to the National Burn Hospital from 1/1/2016 to 31/12/2018. Demographic data and pre-existing medical conditions were collected.

Impact of instituting hard-waiver on a student health insurance program at a public university.

The purpose of this study is to assess the impact of implementing hard-waiver on the student health insurance landscape at a major public university. Data from two years before (2013-2015) and after (2015-2017) the hard-waiver program was implemented were analyzed descriptively using the university data sources. : The university-sponsored insurance group pre-waiver was made up of 4,850 students, while this group included 9,002 students after the hard-waiver program was implemented.

Anti-inflammatory secondary metabolites from the stems of Millettia dielsiana Harms ex Diels.

A phytochemical investigation for the constituents of the stems of Millettia dielsiana Harms ex Diels resulted in the isolation of a new isoflavone glycoside, mildiside A (1), and 14 known compounds (2-15). Their chemical structures were determined using a combination of IR, NMR, MS, and optical rotation analysis, as well as comparison with the literature data. The ethanolic (EtOH) extract and several isolated compounds exert the inflammatory effect of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine RAW264.

Epidemiology of severe buprenorphine exposures reported to the U.S. Poison Centers.

Objective: This study aims to evaluate the trends and risk factors of severe buprenorphine outcomes (SBO) reported to the U.S. Poison Centers (PCs).

Development and validation of a risk predictive model for student harmful drinking-A longitudinal data linkage study.

Background: This study aimed to develop a predictive model to quantify the risk of student harmful drinking associated with emergency department (ED) visits and/or campus-wide incidents reported to campus authorities in a U.S. public university.

A self-encapsulated porous Sb-C nanocomposite anode with excellent Na-ion storage performance.

In this study, a self-encapsulated Sb-C nanocomposite as an anode material for sodium-ion batteries (SIBs) was successfully synthesised using an SbCl-citrate complex precursor, followed by a drying and calcination process under an inert N atmosphere. When the molar ratio of SbCl to citric acid was varied from 1 : 1 to 1 : 4, the Sb-C nanocomposite with a molar ratio of 1 : 3 (Sb-C3) exhibited the highest specific surface area (265.97 m g) and pore volume (0.

Trends and characteristics of naloxone therapy reported to US poison centers.

Background And Aims: In the United States, access to naloxone has been expanded as a measure to address growing opioid overdose mortality. The study aimed to describe the national trends in naloxone use as reported to the US poison centers (PCs).

Methods: The National Poison Data System (NPDS) was queried for cases reporting naloxone therapy from 1 January 2001 to 31 December 2016.