The BRD4-NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma.

Unlabelled: NUT carcinoma (NC) is an aggressive squamous carcinoma defined by the BRD4-NUT fusion oncoprotein. Routinely effective systemic treatments are unavailable for most NC patients. The lack of an adequate animal model precludes identifying and leveraging cell-extrinsic factors therapeutically in NC.

Efficiency of three treatment strategies on occupational and quality of life impairments for chronic low back pain patients: is the multidisciplinary approach the key feature to success?

Objective: To compare the effectiveness of three treatment strategies for chronic low back pain with varying biomechanical intensity and multidisciplinary approach.

Methods: A monocentric randomized controlled trial with a 12-months follow-up, conducted in the French Valley Loire region from May 2009 to April 2013. Participants were working-aged patients with chronic low back pain referred to a French chronic low back pain care-network to support medical and occupational issues.

Effectiveness of three treatment strategies on occupational limitations and quality of life for patients with non-specific chronic low back pain: Is a multidisciplinary approach the key feature to success: study protocol for a randomized controlled trial.

Background: Chronic low back pain (cLBP) is a significant public health problem, being the primary cause of work absenteeism, as well as affecting sufferers' quality of life, in industrialized society. International guidelines recommend intensive multidisciplinary approaches for patients with cLBP. However, these costly and time-consuming programs can only be offered to a minority of the most heavily affected patients and therefore do not seem likely to respond to public health requirements.

[Adapted physical activity for caregivers suffering from low back pain].

Chronic lower back pain is a common condition in caregivers. The Capucins regional rehabilitation centre in Angers supports these allied healthcare professionals through adapted physical activities.

Dependent patients discharged home from PRM departments: relevant indicators.

Objective: To evaluate simple, measurable indicators of optimal organizational procedures for the hospital-to-home discharge of dependent patients.

Material And Method: All the general practitioners (GPs) in the Maine-et-Loire county of France were sent a questionnaire asking them to rank the three main criteria (from the most important to the least significant) from a list of 14. We analyzed the median ranking for each item and identified the most important items in terms of their relative frequency.

Return to work of 87 severely impaired low back pain patients two years after a program of intensive functional rehabilitation.

Unlabelled: Return to work is the main long-term objective of rehabilitation programs for patients with chronic low back pain (LBP).

Objectives: Evaluation of work status and number of sick leaves in 87 severely impaired LBP patients 2 years after a functional restoration program.

Patients And Methods: Open prospective study.

Management of low back pain in primary care prior to multidisciplinary functional restoration: a retrospective study of 72 patients.

Objective: Chronic low back pain is a major socioeconomic health issue, due to the high direct (healthcare) and indirect (sick leave) costs. The aim of the present study was to describe the primary care management of low back pain patients prior to their inclusion in a multidisciplinary functional restoration network.

Methods: A descriptive, retrospective, questionnaire-based survey of the general practitioners dealing with 72 low back pain patients.

Comparison of a functional restoration program with active individual physical therapy for patients with chronic low back pain: a randomized controlled trial.

Objective: To compare the short-term outcomes of active individual therapy (AIT) with those of a functional restoration program (FRP).

Design: Prospective randomized controlled study.

Setting: Two rehabilitation centers and private ambulatory physiotherapy facilities.

[Prospective study of the outcome at one year of patients with chronic low back pain in a program of intensive functional restoration and ergonomic intervention. Factors predicting their return to work].

Objectives: Evaluation of 1-year outcome after patients with chronic low back pain participated in an intensive functional restoration program associated with an ergonomic intervention on the workplace. Study of the factors predicts a return to work.

Methods: Prospective study of a cohort of 87 patients face major difficulties due to low back pain at work.

Effects of functional restoration versus 3 hours per week physical therapy: a randomized controlled study.

Study Design: Randomized parallel-group comparative trial with a 6-month follow-up period.

Objective: To compare, in chronic low back pain patients, the effectiveness of a functional restoration program, including intensive physical training, occupational therapy, and psychological support to an active individual therapy consisting of 3 hours physical therapy per week during 5 weeks.

Summary Of Background Data: Controlled studies conducted in the United States showed a benefit of functional restoration in patients with low back pain, especially on return to work.

[Clinical and developmental aspects of Horton's disease. Retrospective study of 100 cases].

100 patients, from three internal medicine departments, were the subject of a retrospective study concerning the clinical manifestations and the evolution of Horton's disease. The mean age is 71 years, with a 2/1 female predominance. A temporal artery biopsy was obtained in all cases.