[Identification of rat and human hemoglobin acetilation sites after its interaction with acetylsalicylic acid].

The possibility of interaction of 0.1 mg/mL acetylsalicylic acid with purified human and rat globin in vitro during 24 h at 37 degrees C was investigated. The rat globin can be modified with acetylsalicylic acid on aminoacid residues K-17, K-57, K-91, K-140 in alpha subunit as well as on K-18, K-77 in beta subunit.

[Using of metal-affinity chromatography for identification of alkylated rat globin].

Rat globin peptides alkylated by sulfur mustard on amino-acid residues C-126, C-93 and E-27 with MH+ 1444.62 Da, 1561.66 Da, 1676.

[Epidemiological importance of soil and water reservoirs in the natural foci of cryptosporidiosis].

The main penetration route of cryptosporidia oocysts (at the infective stage) from animal carriers in the natural ecosystems of the forest zone into the environment of human habitat has been newly established. Oocysts excreted with feces are concentrated in the surface layer of the soil, then washed into water reservoirs. The viability of oocyts from the soil and the silt of river sand banks and shallows has been experimentally shown.

[Impact of the time of outpatient monitoring of patients with implanted pacemakers to evaluate dangerous changes in the parameters of apparatuses].

Patients with implanted pacemakers (PM) should pass outpatient monitoring at definite intervals given in the PM certificate. The paper shows that the monitoring periods in the patients are frequently violated, therefore the voltage of the PM battery is less than the critical level at which the PM is to be replaced. As the discharge of the battery is less than the critical level, the electronic unit of the PM begins first to regenerate an irregular sequence of stimulating pulses and then the generation of pulses stops.

[Transesophageal cardiac stimulator Stikar-39 for emergency therapy].

A portable "STICAR-39" apparatus for emergency transesophageal and endocardial pacing is described. The apparatus is the smallest, most light-weighed, and power-efficient transesophageal cardiac stimulator in the world. It is effective in emergency medical care, urgent and critical cases, surgery, resuscitation, and intensive therapy.

[Cardiomyoplasty--a surgical method of treatment in heart failure].

Until recently heart transplantation has been the only method of surgical treatment of severe myocardial heart failure. In the recent years operations of cardiomyoplasty have been performed more and more often for treatment of patients with this disease. The article presents the literature and personal data on the operation technique, indications and contraindications for it.

[An apparatus for diagnosing necrotic areas of the skeletal musculature of man and animals].

Modern methods for the evaluation of principal respiration indexes were analysed to formulate the demands for methodological characteristics of the devices used in lung functional diagnosis. As a result the extent of measurement random errors of main respiration indexes, which guarantee the prescribed level of right diagnosis probability are established.

[Analysis of the heterogeneity of chromatin proteins fractionated on hydroxyapatite].

The protein composition of the liver chromatin has been studied by two techniques for fractionation of histones. The "lability" fraction of histones H2A-H2B is revealed. In these fractions histones H2B have many modified forms and they are not included into octamer (H3, H4, H2A, H2B)2.

[Changes in the compactness of nucleosome chromatin from the bovine liver during aging].

Electrophoresis methods used to study the fragments of chromatin revealed under the effect of Ca,Mg-dependent endonuclease on it have permitted establishing that stability of chromatin to the nucleosome level increases with aging. Changes in the compactness of the chromatin structure with aging make the accessibility of the linker DNA to nuclease lower the size of DNA fragments corresponding to mononucleosomes increasing from 192 +/- 5 pairs of bases to 209 +/- 5 pairs. Stabilization of the chromatin structure begins from certain nucleosomes which become more compact with the age.

[Basis for the discreteness of delay and frequency in diagnostic cardiostimulation].

The article presents the metrological, electrophysiological and economic aspects of the substantiation of the choice of the optimal discreteness of impulses and their frequency in diagnostic programmed cardiostimulation. It has been shown that in conducting the intracardiac electrophysiological examination the traditional choice of the discreteness of the interval delta T3 = 10 msec, and the discreteness of the frequency delta Fc = 10 impulses/min does not meet the metrological requirements. From the metrological viewpoint, the minimal values of the discreteness constitute delta T3 = 20 msec and delta Fc = 20 impulses/min, which are compatible with obtaining diagnostic information and thus justified from the clinical and expedient from the economic point of view.

[Method of devising a muscle pump for assisted circulation].

The authors have proposed a model of the blood pump from the skeletal automuscles of the body for carrying out aortal counterpulsation under experimental conditions. The pump is run by means of direct electric stimulation of the muscle. Have demonstrated that it is possible in principle to design a completely implanted small system of aortal counterpulsation.

[Contactless indicator of the rhythm of implanted pacemakers].

Non-content indicators of the rhythm are employed to exercise operative control over the functions of implanted cardiostimulators. The paper discusses issues concerned with the circuitry and the setup of subassemblies in such indicators, e.g.

[Apparatus and electrodes for nerve stimulation].

To successfully accomplish stimulation of a nerve a portable stimulator with bipolar electrodes has been designed. The level of the nerve trunk resistance was found to comprise 6 kOm. The threshold pulsed current amplitude at which the effect becomes apparent lies within the range of 1-2 mA, with the threshold of the potential pulses amplitude amounting to 4-12 V.