[Calcitonin-cells in the thyroid of the human fetus. Immunocytochemical study (author's transl)].

Calcitonin (CT)-cells were detected, by using an anti-human calcitonin serum (hCT), in the thyroid of the normal and anencephalic human fetuses. The first CT-cells were observed at 14 weeks of gestation. The CT-cells were at first isolated afterwards were appeared in parafollicular localization.

Ultrastructural localization of immunoreactive corticotropin, beta-lipotropin, alpha- and beta-endorphin in cells of the human fetal anterior pituitary.

Cells immunoreactive with anti-alpha-(17-39) ACTH, beta-(1-24) corticotropin, beta-LPH, alpha- and beta-EP were identified in the human fetal anterior pituitary at the ultrastructural level using the peroxidase-antiperoxidase complex method on ultrathin sections. Only one definite cell type was revealed by all these antisera. All granules of each individual immunostained cell reacted regardless of the antiserum used.

The genetics of teratocarcinoma transplantation: tumor formation in allogeneic hosts by the embryonal carcinoma cell lines F9 and PCC3.

Two cultured lines of murine embryonal carcinoma, F9 and PCC3, have been grafted to a variety of allogeneic hosts. The host strains have been classified by their resistance or sensitivity to these carcinomas. Resistance seems to be immunological in nature.

Immunologic localization of alpha- and beta-endorphins and beta-lipotropin in corticotropic cells of the normal and anencephalic fetal pituitaries.

The use of antibodies to alpha-(17--39) ACTH, beta-LPH, and alpha- and beta-endorphins has enabled the detection of immunoreactive cells as early as the eight week of fetal life. Immunoreactive cells are located in the anterior and intermediate lobes of the pituitary gland in normal human fetuses. The same cells reacted with different antisera used in the present study.

Giant air cells of the petrous apex: tomographic features.

Sixteen hundred consecutive tomographic examinations of the temporal bones were reviewed and 15 patients with petrous apical air cells larger than 1.5 cm diameter were encountered. Familiarity with the normal tracts of pneumatization, and precise localization of atypical air cells by tomography are helpful in differentiating deformity of the internal auditory canals due to asymmetric pneumatization from the change caused by acoustic neurilemmomas.

Absence of reaction of a xenogenic anti-H-2 serum with mouse embryonal carcinoma cells.

A rabbit antiserum raised against papain-solubilized H-2 antigens has been used to investigate the eventual expression of H-2 antigens and related molecules on embryonal carcinoma cells and on other types of mouse cells. No material reacting with this serum could be detected on cells carrying the F9 antigen. It is concluded that no H-2 antigen or cross-reacting material is expressed on these cell types.

Immunocytological localization of LH, FSH, TSH and their subunits in the pituitary of normal and anencephalic human fetuses.

Immunostaining with antisera to oLH, hCG, hLH, pLHbeta, hFSH, hFSHbeta, hTSHalpha and bTSH was used to delineate the gonadotropic and thyrotropic cells of the human fetal anterior pituitary. Hypophyses from 29 normal fetuses, 3 newborn infants, and 5 totally ancencephalic fetuses were used. Several controls to check for the specificty of the immunocytological reaction were made.

Galactorrhea, amenorrhea, hyperprolactinemia, and an empty sella.

Increased serum prolactin (hPRL) and increased volume of the sella turcica as detected by roentgenography are compatible with a pituitary adenoma. The empty sella syndrome can increase sella volume, but is usually associated with minimal, if any, endocrine dysfunction. The present case details a young woman with amenorrhea, galactorrhea, elevated serum hPRL, and roentgenographic evidence of an enlarged sella turcica.

Patho-radiologic correlation of invasive pulmonary aspergillosis in the compromised host.

The autopsy findings and antemortem radiographic abnormalities were correlated in 20 patients with invasive pulmonary aspergillosis to define typical radiographic patterns, their progression and anatomic basis. Sixteen (80%) patients had radiographic abnormalities due to aspergillosis. Fifty-nine percent of the specific radiographic abnormalities seen in these patients were caused by anatomic lesions of asperigillosis and 67% of such anatomic lesions were radiographically definable.

Visualization of small extracanalicular neurilemomas by metrizamide cisternographic enhancement.

Metrizamide (Amipaque) computerized tomography cisternography (CTC) provides a rapid, simple, and accurate radiographic modality of intrathecal enhancement for detecting and morphologically characterizing cerebellopontine (CP) angle masses. The technique is of especial value in masses greater than 1.5 cm that are not detected on intravenously enhanced computerized tomography.

Immunohistochemical identification and localization of pancreatic polypeptide cells in the pancreas and gastrointestinal tract of the human fetus and adult man.

Pancreatic polypeptide (PP)-containing cells were detected by using anti-bovine PP (BPP) serum in the pancreas and gastrointestinal tract of human fetuses, premature infants and in the pancreas, antrum and jejunum of adult man obtained by biopsy from patients with normal gastroduodenal endoscopy. The localization was established by studying the distribution of PP cells in comparison to the distribution of glucagon-, somatostatin- and insulin cells. The first PP cells are seen in the pancreas at 10 weeks of gestation.

Immunocytological evidence for oxytocin neurons in the human fetal hypothalamus.

The use of antibodies against oxytocin or neurophysin enabled the detection by immunocytochemistry of oxytocin-neurophysin neurons in the hypothalamus in the human fetus. The perikarya of these neurons are located in the paraventricular and supraoptic nuclei. Immunoreactive neurons occure in the median eminence.

Case report: subependymal and leptomeningeal spread of systemic malignant lymphoma demonstrated by cranial computed tomography.

Secondary involvement of the central nervous system by systemic malignant lymphoma is uncommon, although increasingly recognized. Histologically perivascular, leptomeningeal, and subependymal infiltration by tumor cells is characteristic. Less frequently, single or multiple macroscopic masses resembling other metastatic deposits are found.

[Immunofluorescent localization of beta-lipotropin (beta-LPH) and beta-endorphins in normal and anencephalic human fetal pituitary gland].

The use of antibodies to alpha-(17-39) ACTH, beta-LPH, alpha- and beta-endorphins has enabled the detection of immunoreactive cells in human fetal pituitary glands as early as the eight week of gestation. The same cells reacted with the different antibodies. Immunoreactive cells were also observed in the pituitary of 6 human anencephalic fetuses.

An evaluation of current diagnostic radiologic modalities in the investigation of acoustic neurilemmomas.

The radiologic investigation of patients with suspected acoustic neurilemmomas may include specialized plain films, thin-section tomography, CT scanning with intravenous contrast enhancement, Pantopaque cisternography, radionuclide scanning, angiography, and pneumoencephalography. Recently we have used intrathecally enhanced (Amipaque)2 CT cisternography tostudy the cerebellopontine angles and fourth ventricle. An assessment is made of the differential diagnostic value and limitations of radiologic modalities both in tumor detection and in accurate localization.

[Effects of hexamethylenebisacetamide on the differentiation of embryonal carcinoma cells].

HMBA induces differentiation in the whole population of some multipotential embryonic carcinoma cells. Morphological, biochemical and immunological changes can be observed even after short treatment. The cells lose the embryonal F9 antigen without acquiring H-2 antigens.