[Clinical and immunological characteristics of hiv-infection in patients with Asp299glly polymorphism of the Toll-like receptor 4 gene].

The prevalence of Asp299Gly polymorphism of the TLR4 gene and its impact on the clinical and immunological characteristics of HIV infection were investigated. Asp299Gly polymorphism of the TLR4 gene was observed significantly in HIV-infected patients - 12.0 % as compared with controls (2.

[Effect of supposed radioprotectors on oxidation-reduction of vitamin E in the tissues of irradiated rats].

In experiments with mature Wistar male rats under irradiation by dose of 5 Gy the effect of emoxypine, citomedine and echinacea purpurea on the content of liposoluble vitamin A, carotene, vitamin E and its metabolites (quinone and oxidized tocopherol) in blood plasma, spleen, liver and testes was studied. It was shown the drugs under study mobilized the internal reserves of these vitamins and promoted effective functioning of vitamin E redox system. Mechanisms of their action are different.

[Electron microscopic and cytointerferometric study of the cortical neurons from the 2d-generation progeny of preneurosensitized female rats].

A study was made of the sensorimotor cortex of the brain of the second generation offspring of preneurosensitized female rats. Vacuolization of the neurocyte nuclei, elevated lability of nuclear membranes, appearance of numerous dark neurons were discovered at all times of postnatal ontogenesis (from 2 to 90 days). At the same time ultrastructure of a considerable number of neurons was unchanged.

[Membrane bodies in the nuclei of cerebral cortex neurons of the progeny of rats sensitized to brain antigen].

The ultrastructure of sensomotor cortical neurons was studied by electron microscopy in young rats born to females sensitized with brain antigen before mating. Different membranous inclusions were discovered in neuronal nuclei. The membranous bodies were seen on the second day after birth and could be detected until day 60.

[Histological and electron microscopic study of the cerebral cortex of the progeny of neurosensitized rats].

The sensomotor brain cortex of 30-day ratlings born by preliminary neurosensitized females, was studied. The studies demonstrated retardation in the development of the brain cortex in the progeny. Electon microscopic examinations detected certain features in the structure of cellular organella, as well as membrane formations in the nuclei of the cortical neurons.

[Effect of neuroleptics of the phenothiazine series on the impulse activity and ultrastructure of the cortical neurons of rabbits].

Experiments on rabbits showed that chlorpromazine given in a dose of 5 mg/kg produced a disaggregation of polysomes, dilatation of the cysterns of the endoplasmic reticulum, hypertrophy of the Golgi apparatus and swelling of the mitochondria in the majority of the cortical neurons. To these ultrastructural changes corresponded the inhibition of the pulse activity of the nerve cells. In difference from chlorpromazine, trephthazine given in the same dose caused a thickening of the matrix of a part of the neurons, accompanied by an increase in the pulse activity of a group of the cortical cells (28%) under the effect of triphthazine.