[Role of the genetic factors, detoxication systems and oxidative stress in the pathogenesis of endometriosis and infertility (review)].

The aim of this paper is to provide a systematic review of the role of the genetic factors, detoxication systems and oxidative stress in the pathogenesis of endometriosis and infertility. Endometriosis and infertility are still both the most uncommon diseases in gynecology. Many aspects of female reproductive function are strongly influenced by genetic factors, and numerous studies have attempted to identify susceptibility genes for disorders affecting female fertility such as polycystic ovary syndrome, endometriosis, fibroids, cancer (ovarian, vulvar, cervical), premature ovarian failure, recurrent pregnancy loss and pre-eclampsia.

[Oncogynecological aspects of adnexal masses].

Unlabelled: Adnexal masses are frequently found in both symptomatic and asymptomatic women. The frequency of them is 7,8% in reproductive aged women and 2,5-18% in postmenopausal patients.

Aim: to investigate clinical significance of the Risk of Malignancy Index (RMI) and to compare it with histological findings in patients with adnexal masses.

[The clinico-epidemiological characteristics of myotonias in Saratov Province].

The paper summarizes data on the epidemiology and clinical polymorphism of the major types of myotonias. Presents both familial and sporadic cases of myotonia congenita, atrophica, dystrophica, and Eulenburg's [correction of Eilenburg's] paramyotonias. Describes the clinical picture of Thomsen's disease in childhood.

[Atypical spinal amyotrophy in adults].

The authors describe the clinical pleomorphism of atypical spinal amyotrophy of adults (ASAA) characterized by lesions of the anterior horn structures of the cervical part of the spinal cord as well as by the spreading of the process along the entire length of the spinal cord and to the bulbar part of the spine. This is supported by the electrophysiological and morphological data. The disease begins at the 3d and 4th decades of life and progresses to the lethal outcome due to cardiopulmonary insufficiency.

[Expectant mothers from other cities hospitalized for delivery in Moscow].

An analysis was made of geographical structure of women in childbirth from other towns who were admitted to maternity homes of Moscow during a year. Regions and districts were identified from which the flow of women was the greatest, a comparison was made with the number of deliveries in each region and also with educational level of women in these regions.

[Polymorphism of hereditary atypical spinal amyotrophy in adults].

The authors describe the clinical picture and morphological changes in the spinal cord and skeletal muscles associated with hereditary atypical spinal amyotrophy observed in adults living in the Saratov region. The intra- and interfamilial polymorphism of the disease and its prevalence in the region are considered.

[Characteristics of metabolism of human erythrocytes after long-term space flight].

Before and after the 150-day Salyut-7 flight the crewmembers were examined for their red blood metabolism, viz: major metabolic pathways (glycolytic and pentosophosphate), erythrocyte resistance, membrane permeability and lipid peroxidation rate. The resulting data indicate that the metabolic and membrane changes were not pathological and can be classified as adaptive.

[31P-NMR study of kinetics of 2,3-diphosphoglycerate degradation in human erythrocytes during their depletion].

2.3-Diphosphoglycerate degradation kinetics was studied under conditions of human erythrocyte depletion, using the method of 31P-NMR of high performance. The kinetic curve was shown to have a plateau during the first 1.

[Myocardial lesions in several forms of progressive muscular atrophy].

Using the clinical, electrocardiographic, biochemical and morphological findings, the authors assessed the cardiovascular system in 30 patients with Duchenne's myopathy and spinal amyotrophy. An analysis of the material revealed considerable metabolic-dystrophic changes in the myocardium, being more pronounced with Duchenne's myopathy. The early diagnosis of myocardial damage in the above diseases can be made on the basis of evidence from the isoenzymic spectrum of creatine kinase.

[Variability of hereditary spinal amyotrophies].

Under conditions of the former isolate in 13 patients from 8 families hereditary spinal amyotrophy of adults was revealed, which is not in compliance to any other forms of this disease. The disease manifests in several generations of families at the age of 30--40 years in the form of anterior horn lesion to the cervical level in combination with the moderate "bulbar" and pyramidal disorders. The development of the disease is slow.

[Polymorphism of Charcot-Marie-Tooth neural amyotrophy in uniovular twins].

The paper is concerned with a description of an atypical clinical picture of Charcot-Marie-Tooth neuronal amyotrophy in 2 eight-year old monozygotic twins. The traits of the disease were characterized by a deformation of the feet, mild cerebellar symptoms, development of ptosis and other myopathical symptoms, an enlargement of the transversal nerve of the neck and a distribution of the process to the proximal parts. The diagnosis was confirmed by EMG studies.

[Condition of the nervous elements of skeletal muscle in Duchenne myopathy].

In order to determine the role of the nervous system in the pathogenesis of myopathy, the author examined the nervous apparatus in a bioptate of the widest muscle of the back in 8 patients with Duchenne's myopathy and in some other muscles in one post-mortem case of the same disease. The morphological changes in the nervous structures of skeletal muscles were expressed in signs of irritation, substituted by destruction which began in the terminal parts and was more expressed in the atrophized muscles. Besides there were symptoms of excessive growth of the nervous filaments especially in the initial phases of the process.