On mechanism of antioxidant effect of fullerenols.

Fullerenols are nanosized water-soluble polyhydroxylated derivatives of fullerenes, specific allotropic form of carbon, bioactive compounds and perspective pharmaceutical agents. Antioxidant activity of fullerenols was studied in model solutions of organic and inorganic toxicants of oxidative type - 1,4-benzoquinone and potassium ferricyanide. Two fullerenol preparations were tested: СО(ОН) and mixture of two types of fullerenols СО(ОН)+СО(ОН).

Studying progression from glucose intolerance to type 2 diabetes in obese children.

Aim: Identification of metabolic and genetic factors capable to mediate progression from normal glucose tolerance (NGT) through impaired glucose tolerance (IGT) to type 2 diabetes (T2D) in childhood obesity.

Patients And Methods: Three groups of obese children with NGT (n=54), IGT (n=35), and T2D (n=62) were evaluated. A control group of non-obese normal children (n=210) was also studied.

[Specific features of source-sink relations in alloplasmic hybrid of winter wheat with alien cytoplasm of goatgrass with emphasis on resistance to low temperature stress].

We studied the influence of alien cytoplasm of spring goatgrass Aegilops ovata L. on some physiological parameters in winter wheat (Triticum aestivum L.), Mironovskaya 808, under normal conditions and in the case of modified source-sink relations.

[Morphophysiological monitoring of winter wheat at spring in connection with problem of global climate change].

Data on morphophysiological monitoring of winter wheat (Triticum aestivum L.) cultivar Mironovskaya 808 grown in Hoagland and Arnon solution in a greenhouse and transferred to natural conditions in March-April 2004 with the mean daily temperature of 0.6 +/- 0.

[Lipid peroxidation parameters and activities of lysosomal enzymes in patients with diabetes mellitus].

The processes of lipid peroxidation and activities of lysosomal enzymes were studied in 56 patients with type I and II diabetes mellitus. The rate of lipid peroxidation of red cell membranes was assessed from the activities of enzymatic (NADPH-dependent) and nonenzymatic (ascorbate-dependent) lipid peroxidation, from accumulation of acylhydroperoxides, intermolecular joints, and from spontaneous red cell hemolysis. Activities of lysosomal enzymes (cathepsins, acid DNAse, and beta-galactosidase) were measured in leukoconcentrate.

[Activity of lysosomal enzymes in diabetes mellitus patients along with diffuse enlargement of the thyroid gland].

Activity of lysosomal enzymes was studied in 68 patients with Types 1 and 2 diabetes mellitus concurrent with diffuse thyroid enlargement. A decrease in activities of beta-galactosidase and DNAase and activation of cathepsins were detected in the leukocytes fraction from patients with Types 1 or 2 diabetes mellitus, thus demonstrating that metabolic impairments occurred in diabetes mellitus. These patterns were improved after intensive insulin therapy.

[Assessment of the functional status of the engineering-technical staff at a machine-building plant].

For early detection of functional disorders and risk-factors among the engineering staff at a machine-building plant, a set of highly informative, physiologically grounded and accessible techniques were used. To improve the patterns of out-patient screening of the staff, the contributors used physiologic and psychologic testing techniques, ECG monitoring registration in dynamics in the real occupational conditions, and riskometry, which facilitated the substantiation procedures for individual medical recommendations.

[The treatment of diabetic angiopathies by endovascular low-intensity laser irradiation].

A study was made of the effect of endovascular laser irradiation of the blood with a He-Ne laser on blood rheological properties, tissue microcirculation and leukocyte function in 28 patients suffering from diabetes mellitus with diabetic angiopathies. A course of endovascular laser irradiation of the blood resulted in the improvement of a clinical course of angiopathies, indices of biomicroscopy of the eye conjunctiva as well as capillaroscopy and thermogenic activity of the limbs. Blood viscosity was significantly decreased; noticeable stimulation of leukocyte beta-galactosidase from 16.

[Methodological approach to the evaluation of health status of white-collar workers].

According to the results of a complex examination of white-collar workers the data on medical checkups, assessment of the body functional state, mental and physical work capacity, risk factors were used as criteria of their health status. Three levels of health were conditionally determined and individual measures aimed at primary and secondary disease prevention motivated along with their terms and tactics.

[Free amino acid spectrum and cathepsin activity in the blood serum of patients with diabetes mellitus combined with diffuse toxic goiter].

Clinicobiochemical studies were performed to determine the spectrum of free aminoacids and cathepsin activity in the blood serum of 96 patients with the moderate stage of diabetes mellitus, diffuse toxic goiter, accompanied by normo- or hyperglycemia and in combined pathology: diabetes mellitus and diffuse toxic goiter. Pronounced hyperaminoacidemia in moderate diabetes mellitus, moderate hyperaminoacidemia in diffuse toxic goiter with normo- or hyperglycemia and increased cathepsin activity were revealed. In combined pathology mild thyroid hyperfunction diminished hyperaminoacidemia and cathepsin activity in patient with diabetes mellitus, apparently rendering a positive effect on protein-aminoacid metabolism.

[Isolation and properties or uridine kinase from Zajdela hepatoma cells].

Uridine kinase (ATP: uridine-5-phosphotransferase, EC 2.7.1.

[Change in the correlation of 2 RNA precursor synthesis pathways in the tissues of animals with rapidly growing hepatomas].

In the spleen, thymus and liver of mice and rats carrying transplantable rapidly growing hepatomas a shift between the de novo and "salvage" pathways of the pyrimidine RNA nucleotides synthesis in favour of the de novo one was observed. The phenomenon was found to be the manifestation of a drastically diminished uridine utilization by the host tissues, this precursor being preferentially and avidly used by the tumour for its own RNA synthesis. The above findings are regarded as the result of a successful competition of the tumour with the host tissues for vital metabolites representing one of the forms of the systemic effects of malignant neoplasms.