Efficacious elimination of intramolecular charge transfer in perylene imide based light-harvesting antenna molecules.

Two light-harvesting antenna molecules were obtained by positioning naphthalene monoimide energy donors at the imide position, instead of the bay positions, of perylene imide energy acceptors. Such rational design resulted in a complete suppression of parasitic intramolecular charge transfer without compromising the desired ultrafast rates of excitation energy transfer.

Distinct defensive activity of phenolics and phenylpropanoid pathway genes in different cotton varieties toward chewing pests.

Identifying the maximum level of inherent defense against harmful insects in natural variation among wild lineages of crop plants may result in high yield tolerant varieties and reducing use of chemical insecticides. However, knowledge of natural cotton genotypes with high insect-resistance is still indistinguishable at the biochemical or molecular level. In the present study, different cultivated varieties were evaluated for their inherent insect-tolerance against two major cottons chewing pests.

Evaluation of intrahepatic and extrahepatic biliary tree anatomy and its variation by magnetic resonance cholangiopancreatography in Odisha population: a retrospective study.

Intrahepatic and extrahepatic anatomical knowledge is essential for pre procedural planning of liver transplantation, liver resection, complex biliary reconstruction and radiological biliary tree intervention. Indian data of biliary anatomy and its variation is scant in literature. The aim of our study is to find out the prevalence of common and uncommon pattern of biliary tree anatomy in magnetic resonance cholangiopancreatography (MRCP) in our population.

Identification, isolation, structural characterisation, synthesis and toxicity prediction of the alkaline hydrolytic degradation product of brivaracetam by using LC-PDA, preparative HPLC, LC/HESI/LTQ, FTIR, and H NMR.

Brivaracetam is a racetam derivative of levetiracetam with very limited data available on its degradation behaviour. An official HPLC method for brivaracetam has not been published yet to resolve the degradation products generated during stability studies. Therefore, an isocratic reverse phase HPLC-UV method was developed for the determination of brivaracetam in the presence of its related impurities and degradation products.

Sustainable agronomic practices for enhancing the soil quality and yield of Cicer arietinum L. under diverse agroecosystems.

Sustainable agronomic practices are being implemented worldwide to promote the cleaner and planet friendly crop production. Therefore, in the present study, we investigated the effect of agro-waste derived biochar and vermicompost on soil quality and yield in Cicer arietinum L. Field experiment was carried out at three different agro-climatic regions (Varanasi, Sultanpur and Gorakhpur) of Uttar Pradesh, India and periodic soil and crop sampling were done accordingly.

Exploration of Diosmin to Control Diabetes and Its Complications-an In Vitro and In Silico Approach.

Background: Diosmin is a flavonoid obtained from the citrus fruits of the plants. Diosmin has blood lipid lowering activities, antioxidant activity, enhances venous tone and microcirculation, protects capillaries, mainly by reducing systemic oxidative stress.

Objective: The present study demonstrates the potential of Diosmin against the enzymes aldose reductase, α-glucosidase, and α-amylase involved in diabetes and its complications by in vitro evaluation and reverse molecular docking studies.

and leaf extracts alleviate arsenic toxicity by reducing arsenic uptake and improving antioxidant system in rice seedlings.

In the present study the potentials of aqueous extracts of the two plants, neem () and Tulsi () were examined in alleviating arsenic toxicity in rice ( L.) plants grown in hydroponics. Seedlings of rice grown for 8 days in nutrient solution containing 50 μM sodium arsenite showed decline in growth, reduced biomass, altered membrane permeability and increased production of superoxide anion O ), HO and hydroxyl radicals (OH).

Lipid droplets can promote drug accumulation and activation.

Genetic screens in cultured human cells represent a powerful unbiased strategy to identify cellular pathways that determine drug efficacy, providing critical information for clinical development. We used insertional mutagenesis-based screens in haploid cells to identify genes required for the sensitivity to lasonolide A (LasA), a macrolide derived from a marine sponge that kills certain types of cancer cells at low nanomolar concentrations. Our screens converged on a single gene, LDAH, encoding a member of the metabolite serine hydrolase family that is localized on the surface of lipid droplets.

Reconciling novelty and complexity through a rational analysis of curiosity.

Curiosity is considered to be the essence of science and an integral component of cognition. What prompts curiosity in a learner? Previous theoretical accounts of curiosity remain divided-novelty-based theories propose that new and highly uncertain stimuli pique curiosity, whereas complexity-based theories propose that stimuli with an intermediate degree of uncertainty stimulate curiosity. In this article, we present a rational analysis of curiosity by considering the computational problem underlying curiosity, which allows us to model these distinct accounts of curiosity in a common framework.

Revisiting the plant growth-promoting rhizobacteria: lessons from the past and objectives for the future.

Plant beneficial rhizobacteria (PBR) is a group of naturally occurring rhizospheric microbes that enhance nutrient availability and induce biotic and abiotic stress tolerance through a wide array of mechanisms to enhance agricultural sustainability. Application of PBR has the potential to reduce worldwide requirement of agricultural chemicals and improve agro-ecological sustainability. The PBR exert their beneficial effects in three major ways; (1) fix atmospheric nitrogen and synthesize specific compounds to promote plant growth, (2) solubilize essential mineral nutrients in soils for plant uptake, and (3) produce antimicrobial substances and induce systemic resistance in host plants to protect them from biotic and abiotic stresses.

Combined effects of rhizo-competitive rhizosphere and non-rhizosphere in plant growth promotion and yield improvement of (Ragi).

This study emphasizes the beneficial role of rhizo-competitive spp. isolated from rhizospheric and non-rhizospheric soil in plant growth promotion and yield improvement via nitrogen fixation and biocontrol of causing foot rot disease in (Ragi). The selection of potent rhizobacteria was based on plant-growth-promoting attributes using Venn set diagram and Bonitur scale.

Silicon Oxycarbide-Tin Nanocomposite as a High-Power-Density Anode for Li-Ion Batteries.

Tin-based materials are an emerging class of Li-ion anodes with considerable potential for use in high-energy-density Li-ion batteries. However, the long-lasting electrochemical performance of Sn remains a formidable challenge due to the large volume changes occurring upon its lithiation. The prevailing approaches toward stabilization of such electrodes involve embedding Sn in the form of nanoparticles (NPs) in an active/inactive matrix.

Zeolite-Templated Carbon as a Stable, High Power Magnesium-Ion Cathode Material.

One strategy to overcome the slow kinetics associated with electrochemical magnesium ion storage is to employ a permanently porous, capacitive cathode material together with magnesium metal as the anode. This strategy has begun to be employed, for example, using framework solids like Prussian blue analogues or porous carbons derived from metal-organic frameworks, but the cycling stability of an ordered, bottom-up synthesized, three-dimensional carbon framework toward magnesiation and demagnesiation in a shuttle-type battery remains unexplored. Zeolite-templated carbons (ZTCs) are a class of ordered porous carbonaceous framework materials with numerous superlative properties relevant to electrochemical energy storage.

Clinical Profile, Risk Factors and Outcomes in Patients with Cerebral Venous Sinus Thrombosis: A Study from Western India.

Aim: Study of cause and clinical profile of venous sinus thrombosis in Western India.

Settings And Design: A retrospective study was conducted to ascertain the clinical profile, etiology, and follow up of patients with venous sinus thrombosis.

Methods And Material: Hospital database of patients suffering from venous sinus thrombosis from two tertiary care hospitals in West India were studied.

Synthesis and biological evaluation of potent benzoselenophene and heteroaromatic analogues of ()-1-(chloromethyl)-8-methoxy-2,3-dihydro-1-benzo[]indol-5-ol (-MCBI).

A diverse series of compounds (18a-x) were synthesized from ()-1-(chloromethyl)-8-methoxy-2,3-dihydro-1-benzo[]indol-5-ol (-MCBI) and benzoselenophene or heteroaromatic acids. These new compounds were evaluated for their cytotoxicity against the human gastric NCI-N87 and human ovarian SK-OV3 cancer cell lines. The incorporation of a methoxy substituent at the C-7 position of the -CBI unit enhances the cytotoxicity through its additional van der Waals interaction and gave a much higher potency than the corresponding -CBI-based analogues.

Socioeconomic determinants of chronic health diseases among older Indian adults: a nationally representative cross-sectional multilevel study.

Objective: Study uses multilevel modelling to examine the effect of individual, household and contextual characteristics on chronic diseases among older Indian adults.

Design: Nationally representative cross-sectional study.

Participants: Data from the nationally representative, India Human Development Survey conducted in 2011-2012 was used in this study.

Relation between molecular packing and singlet fission in thin films of brominated perylenediimides.

Perylene diimides (PDIs) are attractive chromophores that exhibit singlet exciton fission (SF) and have several advantages over traditional SF molecules such as tetracene and pentacene; however, their photophysical properties relating to SF have received only limited attention. In this study, we explore how introduction of bulky bromine atoms in the so-called bay-area PDIs, resulting in a nonplanar structure, affects the solid-state packing and efficiency of singlet fission. We found that changes in the molecular packing have a strong effect on the temperature dependent photoluminescence, expressed as an activation energy.

Successful therapeutic plasma exchange in a patient with Morvan syndrome.

Morvan syndrome is a rare autoimmune disorder, characterized by hyperexcitability of both central and peripheral nervous systems, accompanied by autonomic dysfunction and hallucinations. Therapeutic plasma exchange (TPE) has been found to be an effective mode of treatment for this disease, but there is limited literature supporting the same. A 26-year-old male was admitted to our hospital and diagnosed with a case of Morvan syndrome, based on the clinical picture and laboratory findings.

Strategy and Methodology in the Synthesis of Multicomponent Molecular Solids: The Quest for Higher Cocrystals.

Crystal engineering is the art and science of making crystals by design. Crystallization is inherently a purifying phenomenon. Bringing together more than one organic compound into the same crystal always needs deliberate action.

Perylene Bisimide Dyes with up to Five Independently Introduced Substituents: Controlling the Functionalization Pattern and Photophysical Properties Using Regiospecific Bay Substitution.

We report herein a versatile and user-friendly synthetic methodology based on sequential functionalization that enables the synthesis of previously unknown perylene bisimide (PBI) dyes with up to five different substituents attached to the perylene core (e.g., compound ).

Mechanism of 17β-estradiol stimulated integration of human mesenchymal stem cells in heart tissue.

Scarcity of gender specific donor hearts highlights the importance of mesenchymal stem cells (MSCs) as a therapeutic tool for heart repair. However, inefficient incorporation, retention, and activity of MSCs in cardiac tissue remain an obstacle. Since surges in follicular estradiol (E2; μmolar-range) trigger tissue remodeling (e.

In-vehicle PM personal concentrations in winter during long distance road travel in India.

During travel, passengers are exposed to high concentrations of PM which constitute a significant fraction of daily personal exposures. We carried out comprehensive mobile monitoring for a distance of 400km on an Indian National Highway during the winter season to evaluate the PM Personal Concentrations (PC) and mass exposure in three traffic microenvironments (public bus, car with AC (Car CW) and car without AC (Car OW)) and to quantify the key factors that influence it. The mean concentrations were highest inside Car OW (175.

Copper sulfide nanoparticles as high-performance cathode materials for Mg-ion batteries.

Rechargeable magnesium batteries are appealing as safe, low-cost systems with high-energy-density storage that employ predominantly dendrite-free magnesium metal as the anode. While significant progress has been achieved with magnesium electrolytes in recent years, the further development of Mg-ion batteries, however, is inherently limited by the lack of suitable cathode materials, mainly due to the slow diffusion of high-charge-density Mg-ions in the intercalation-type host structures and kinetic limitations of conversion-type cathodes that often causes poor cyclic stability. Nanostructuring the cathode materials offers an effective means of mitigating these challenges, due to the reduced diffusion length and higher surface areas.