Psychometric validation of Dark Tetrad at Work scale in an Indian context.

Dark Tetrad at Work (DTW) scale is a relatively new instrument used for assessing four dark personality traits, namely; Narcissism, Machiavellianism, Psychopathy and Sadism. In an attempt to psychometrically validate and check its suitability for exploring dark traits among Indian employees, we carried out this two phased study. In the first phase, a total of N = 526 participants working in the government run businesses responded to the scale that was distributed via an online and offline approach.

Management of Metastatic Colorectal Cancer (mCRC): Real-World Recommendations.

Introduction: Metastatic CRC is considered as a heterogenous disease. Its management is therefore complex and dynamic. In order the give a ready reference to community oncologists, we developed this real world recommendations.

Prognostic significance of tumor budding in endometrial cancer: clinicopathological insights.

Purpose: Endometrial cancer is one of the most common gynecological cancers worldwide, with rising incidence rates. Despite therapeutic advances, it remains a significant cause of cancer-related deaths. Tumor budding (TB), characterized by single cells or small clusters at the invasive tumor front, is a recognized prognostic marker in several cancers but is less studied in endometrial cancer.

High-efficiency lithium niobate optical mode switch using a mode-loop Mach-Zehnder interferometer.

Mode-division multiplexing is a common technology in photonic integrated circuits, which can combine various optical mode signals into one single channel such as a multimode waveguide to improve the communication system's capacity. Optical mode switch plays a critical role in mode-division multiplexing, which can switch the optical signal into different mode channels. Here, we propose and experimentally demonstrate a high-efficiency optical mode switch with a half-wave voltage length product () of about 1.

Unraveling HPV-associated cancer complexity: From molecular insights to innovative therapies.

Human papillomavirus (HPV) contributes to a high global incidence of sexually transmitted infections, predominantly associated with cervical cancer, as well as head and neck, penile, anal, vaginal, and vulvar cancers. Despite efforts through improved screening and HPV vaccination campaigns, challenges persist, influencing the frequency of HPV-related malignancies. Collaborative scientific endeavors strive to pioneer groundbreaking approaches, aiming to alleviate the adverse consequences of HPV-related malignancies on individuals and communities.

Assessing the imazethapyr herbicide-induced physio-biochemical consequences and phenol and glutathione-associated detoxification in lentil seedlings.

Lentil is an essential edible legume crop, especially for developing countries, due to the presence of high-quality proteins, fibers, essential vitamins, and mineral nutrients. The short height of this crop is often linked with a slow pace of growth, favoring the suitable space and time for weed incursion. Consequently, the developmental period during the crop growth cycle is shortened, leading to a decline in crop productivity.

Associations between procedural volume, costs, and outcomes of septal reduction therapies for obstructive hypertrophic cardiomyopathy in US hospitals.

Aim: We assessed the relationship between hospital septal reduction therapy (SRT) procedural volume and clinical outcomes, healthcare resource utilization, and hospital costs.

Methods: This cross-sectional study used 2012-2022 US hospital data from the PINC AI Healthcare Database for adults with hypertrophic cardiomyopathy (HCM) undergoing alcohol septal ablation (ASA) or septal myectomy (SM; with or without mitral valve repair or replacement [MVRR]). We categorized hospital procedural volume into tertiles according to the numbers of procedures performed and made pairwise comparisons of patient characteristics, clinical events, healthcare utilization, and hospital costs between tertiles.

Drift-diffusive resetting search process with stochastic returns: Speedup beyond optimal instantaneous return.

Stochastic resetting has recently emerged as a proficient strategy to reduce the completion time for a broad class of first-passage processes. In the canonical setup, one intermittently resets a given system to its initial configuration only to start afresh and continue evolving in time until the target goal is met. This is, however, an instantaneous process and thus less feasible for any practical purposes.

Granular gases under resetting.

We investigate the granular temperatures in force-free granular gases under exponential resetting. When a resetting event occurs, the granular temperature attains its initial value, whereas it decreases because of the inelastic collisions between the resetting events. We develop a theory and perform computer simulations for granular gas cooling in the presence of Poissonian resetting events.

In-silico evaluation of diffractaic acid as novel anti-diabetic inhibitor against dipeptidyl peptidase IV enzyme.

Unlabelled: Diabetes mellitus (DM) is one of the most common long-term metabolic illnesses with detrimental implications on health and 90-95% of DM cases worldwide are caused by type 2 diabetes (T2DM). The side effects of the existing medicines include vomiting, diarrhea, and serious damage to the kidneys, blood vessels, and nerves. Therefore, finding anti-diabetic medications without side effects is crucial.

Radiological and Surgical Assessment of Proximity of Roots of Mandibular Third Molar to the Inferior Alveolar Canal in Impacted Teeth.

Background And Objective: A mandibular canal around the lower third molar roots house the inferior alveolar nerve (IAN). There is a risk of nerve injury during surgical tooth extraction.

Methods: The College of Dental Sciences at Davangere's Department of Oral and Maxillofacial Surgery served as the outpatient setting for this investigation.

analysis of visible light cure calcium hydroxide, mineral trioxide aggregate and platelet-rich fibrin with and without laser therapy for direct pulp capping.

The clinical and radiographic outcomes of direct pulp capping using visible light cure calcium hydroxide, Mineral Trioxide Aggregate, and Platelet-Rich Fibrin, with and without pre-treatment with a low-level diode laser is of interest to dentist. One hundred and twenty patients (18-48 years) with accidental minimal pulp exposures less than 1 mm2 were randomized into two primary groups: laser pre-treatment and no laser pre-treatment, each further divided into three sub-groups based on the capping material. Clinical and radiographic assessments were conducted at 7 day, 1, 6 and 12 months.

Exploring the role of organizational identification in the nexus of psychological capital and organizational-oriented citizenship behaviors: evidence from healthcare professionals in India.

Purpose: The purpose of this study is to explore the mediation of organizational identification (OI) in the relationship between employees' psychological capital (PsyCap) and their engagement in organizational-oriented citizenship behaviors (OCBO). We examine the proposed theoretical model through the lens of the job demand and resources (JD-R) model and social identity theory (SIT), focusing specifically on the healthcare setting.

Design/methodology/approach: Employing a structured questionnaire, responses were collected from 240 healthcare professionals working in multinational pharmacovigilance firms in select Tier-I Indian cities using purposive sampling.

Piezo-electronics: A paradigm for self-powered bioelectronics.

Recent breakthroughs in electroactive piezo-biomaterials have driven significant progress towards the development of both, diagnostic and therapeutic purposes, enabling vital sign monitoring, such as heart rate, etc. while also supporting tissue regeneration. Bioelectronic medicine provides a promising method for controlling tissue and organ functions, with 'piezo-electronics' emphasizing the lasting role of electro-active piezo-biomaterials in self-powered devices.

Association of sleep disordered breathing with severity and control of persistent asthma in Indian children.

Objective: To assess the association of pediatric sleep disordered breathing (SDB) with control and severity of asthma, and to evaluate the comorbidities associated with both.

Methods: Based on the Sleep-Related Breathing Disorder scale, extracted from the Pediatric Sleep Questionnaire (SDBS-PSQ), children (5-15 years) with persistent asthma were classified as; with SDB (SDBS-PSQ≥0.33) and without SDB (SDBS-PSQ<0.

Demonstration of a scalable mode converter in lithium niobate on insulator.

Lithium niobate on insulator (LNOI) attracts extensive attention from academic and industrial communities due to LN's excellent electro-optic (EO) properties, which also brings bright prospects for achieving high-speed and large-capacity photonic integrated circuits (PICs) including active and passive components such as modulator, filter, and multiplexer. A mode converter can implement optical mode conversion from a fundamental mode to a high-order mode, which plays a key role in an on-chip mode-division multiplexing (MDM) system. In this Letter, we propose high-performance and scalable mode converters in LNOI, and based on our proposed scalable principle, the mode converter can be designed to implement the optical mode conversion from the fundamental mode to arbitrary high-order mode.

A multi-modal transformer for cell type-agnostic regulatory predictions.

Sequence-based deep learning models have emerged as powerful tools for deciphering the cis-regulatory grammar of the human genome but cannot generalize to unobserved cellular contexts. Here, we present EpiBERT, a multi-modal transformer that learns generalizable representations of genomic sequence and cell type-specific chromatin accessibility through a masked accessibility-based pre-training objective. Following pre-training, EpiBERT can be fine-tuned for gene expression prediction, achieving accuracy comparable to the sequence-only Enformer model, while also being able to generalize to unobserved cell states.

Effectiveness and Safety in Patients with Non-Valvular Atrial Fibrillation Who Switched from Warfarin to Direct Oral Anticoagulants in Medicare Population.

Introduction: Atrial fibrillation (AF), a common heart rhythm abnormality, is linked to a higher risk of stroke. Traditionally, warfarin has been the primary anticoagulation treatment for reducing the stroke risk. The new standard of treatment by direct oral anticoagulants (DOACs) offers greater benefits including improved efficacy and fewer adverse effects with reduced monitoring.

Moving towards single fraction peripheral lung stereotactic body radiation therapy: patient care during and after the global COVID-19 pandemic.

Single-fraction stereotactic body radiation therapy (SF-SBRT) for peripheral lung tumors was reviewed. Medically inoperable peripheral lung tumors eligible for SF-SBRT 34 Gray were treated. Patient characteristics, treatment and toxicity parameters were retrospectively collected, and toxicities were evaluated.

Evolution of Transcription Factor-containing Superfamilies in Eukaryotes.

Regulation of gene expression helps determine various phenotypes in most cellular life forms. It is orchestrated at different levels and at the point of transcription initiation by transcription factors (TFs). TFs bind to DNA through domains that are evolutionarily related, by shared membership of the same superfamilies (TF-SFs), to those found in other nucleic acid binding and protein-binding functions (nTFs for non-TFs).

Development and evaluation of chitosan-coated virgin coconut oil-asiatic acid-loaded nanoemulgel for enhanced wound management.

Wound management remains a significant challenge due to complications such as delayed healing and microbial infections, particularly in the conditions like diabetes mellitus, vascular disorders, and immunosuppression. This study aimed to develop a chitosan-coated virgin coconut oil-asiatic acid-loaded nanoemulsion gel (CS-ASA-NEG) to enhance wound healing outcomes. A central composite design (CCD) was employed using Design Expert 11 software to optimize the nanoemulsion formulation, with ternary phase diagrams (TPD) evaluating stable regions for Tween 20: Span 80 (T20:S80) ratios.

Molecular-targeted Therapy for Precision Medicine in Gastrointestinal Cancer: Advancement in Cancer Targeting Strategies.

Gastrointestinal (GI) cancer represent significant health challenges, affecting the digestive system with often subtle symptoms that can delay diagnosis. GI cancers account for a higher global mortality rate than any other cancer, largely due to the limited availability of highly effective treatment options." Due to next-generation sequencing and new preclinical model tools, that we have learned more regarding its pathophysiology and molecular changes.

Bioprospecting indigenous bacteria from landfill leachate for enhanced polypropylene microplastics degradation.

Plastic pollution, especially microplastics (MPs), is a severe environmental threat. Due to the significant environmental issues posed by plastics, it is critical to use an effective and sustainable degradation technique. The study aimed to isolate and identify Indigenous bacterial strains from landfill leachate (LL) to evaluate its potential for degrading Polypropylene microplastics (PPMPs).

Analysis of the Influence of Manufacturing Technology on Selected Static, Fatigue and Morphological Properties of CFRP Composites.

The aim of this study was to compare the mechanical properties of carbon-fiber-reinforced polymer (CFRP) composites produced using three popular technologies. The tests were performed on composites produced from prepregs in an autoclave, the next variant is composites produced using the infusion method, and the third variant concerns composites produced using the vacuum-assisted hand lay-up method. For each variant, flat plates with dimensions of 1000 mm × 1000 mm were produced while maintaining similar material properties and fabric arrangement configuration.