Quantification of Citrullinated Histone H3 as a Marker for Neutrophil Extracellular Traps Correlated to Clinical Characteristics of Patients with Systemic Lupus Erythematosus.

Systemic lupus erythematosus (SLE) is an autoimmune disease whose pathogenesis is not fully understood to date. One of the suggested mechanisms for its development is NETosis, which involves the release of a specific network consisting of chromatin, proteins, and enzymes from neutrophils, stimulating the immune system. One of its markers is citrullinated histone H3 (H3Cit).

Role of sclerostin in mastocytosis bone disease.

Mastocytosis is a heterogeneous group of disorders, characterized by accumulation of clonal mast cells which can infiltrate several organs, most often spine (70%). The pathogenesis of mastocytosis bone disease is poorly understood. The main aim of the study was to investigate whether neoplastic mast cells may be the source of sclerostin and whether there is an association between sclerostin and selected bone remodeling markers with mastocytosis related bone disease.

Hyperleukocytosis in Pediatric Patients with Acute Lymphoblastic Leukemia: Demographic and Clinical Characteristics.

: Hyperleukocytosis, defined as a total leukocyte count of more than 50,000/mm leukocytes, occurs in almost one in five children with acute lymphoblastic leukemia (ALL). It represents an unfavorable prognostic factor in this disease. The aim of the following study was to describe demographic and clinical features in patients with hyperleukocytosis and their relationship with leukocyte count.

Usefulness in daily practice of the Systemic Lupus Erythematosus Disease Activity Index 2000 scale and the Systemic Lupus Erythematosus Disease Activity Score index for assessing the activity of systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by high heterogeneity of clinical manifestations and an uncertain prognosis. Although the mortality rate due to SLE has decreased significantly in recent decades, there is still a need to find good tools to measure disease activity for early detection of exacerbations and treatment planning. Over the decades, more than a dozen disease activity scales/indicators have been developed, with the SLE Disease Activity Index (SLEDAI) being the most popular.

Coexistence of multiple sclerosis and systemic lupus erythematosus - a case report.

Purpose: Multiple sclerosis (MS) and systemic lupus erythematosus (SLE) are two autoimmune diseases that are relatively common, especially in women. However, it is extremely rare for them to coexist in a single patient (only 18 cases have been recorded worldwide). Both affect the nervous system and may manifest in identical ways.

Role of Non-Coding RNAs in Diagnosis, Prediction and Prognosis of Multiple Myeloma.

Multiple myeloma (MM) is the second most common hematologic malignancy in the world and accounts for 15% of primary hemocytopathies, with an ever-increasing number of new cases. It is asymptomatic in 30% of instances; hence, the determination of highly sensitive and specific markers is necessary to make a proper diagnosis. In the last 20 years, miRNAs, involved in regulating the expression of genes responsible for cell proliferation and differentiation, including tumor cells, have been identified as potential diagnostic and prognostic markers.

Two years of the COVID-19 pandemic from a child's perspective: A narrative review.

The coronavirus disease 2019 (COVID-19) pandemic has been ongoing since 2020. This period is characterized by a significant change in people's lifestyles. Children are a particularly affected group.

Conversions in laparoscopic cholecystectomy.

Authors in this article emphasize the wide use of laparoscopic cholecystectomy in gall bladder surgery. Indications for laparoscopic operations are increasing. In spite of increasing practical experience of surgeons, availability of new instruments, advances of techniques, this problem of conversion is always actual.

Miniinvasive treatment of pericardial effusions.

The aim of our study is to show the clinical potential of laparoscopic treatment of pericardial effusions. In spite of the small number of the patients we want to bring to attention the benefit of this mininvasive procedure. The laparoscopic fenestration is indicated when the pericardial effusion persists after unsuccessful medical treatment and when clinical and echocardiografic signs of tamponade develop (Ref 13).

[Quadruparesis as a complication of acute pancreatitis--case report].

Pancreatic encephalopathy is a rare complication of acute pancreatitis. Clinical features include focal neurological signs and acute oncet of dementia. Clinical picture can fiuctuate over the time and depends on phase of this disease.

[Choledochal cyst complication of pregnancy].

Authors in this case report describe rare complication of pregnancy. Ultrasound examination showed cystic lesion in abdominal cavity. It was indicated caesarean section because of deterioration of patient's condition.

[Postoperative adhesions, the everlasting topical subject].

Creation of postoperative adhesions is a part of every abdominal operation. The authors analyse 320 patients operated for ileus in last 7 years. 118 patients were operated for adhesive ileus.

[Internal hernias--uncommon causes of the status ileosus].

Internal hernia is an uncommon cause of acute intestinal obstruction with. Preoperative diagnosis of an internal hernia is difficult because of the lack of specific signs. Only a few cases of internal hernia have been successfully diagnosed, however, most cases (74%) were initially diagnosed as intestinal obstructions.

[Primary tumors of the duodenum and the small intestine in our clinical study subjects over a ten-year period].

The authors are evaluating occurrence of primary tumors of duodenum and small intestine during last 10 years (1995-2004) as a retrospective study. 13 patients were operated in this period, three of them are presented as case reports. The main clinical symptoms were bleeding and obstruction, two patients had no symptoms.