State estimation for nonlinear state-space transmission models of tuberculosis.

Given the high prevalence of tuberculosis (TB) and the mortality rate associated with the disease, numerous models, such as the Gammaitoni and Nucci (GN) model, were developed to model the risk of transmission. These models typically rely on a quanta generation rate as a measurement of infectivity. Since the quanta generation rate cannot be measured directly, the unique contribution of this work is to develop state estimators to estimate the quanta generation rate from available measurements.