Inhibitory effects of ketamine on the isolated uteri of the rat: evidence for the mechanism of action.

The inhibitory effect of ketamine on the agonist-induced contraction of isolated rat uteri was compared with that of papaverine and verapamil. Under similar experimental conditions papaverine and verapamil were found to be more potent than ketamine. When preparations were preincubated for 20 min with either ketamine (3 X 10(-5) to 10(-3) M) or papaverine (10(-6) to 10(-5) M), a noncompetitive antagonism was observed against oxytocin with pD'2 values of 3.

The effects of posture on blood pressure and heart rate in the three-toed sloth, Bradypus tridactylus.

1. In unanesthetized, minimally restrained three-toed sloths, Bradypus tridactylus, the mean arterial pressure was 125/85 mmHg and the heart rate was 83.6 beats/min.

Association of congenital cystic dilatation of the common bile duct and congenital diverticulum of the hepatic duct with concomitant ascariasis.

A case with association of congenital cystic dilatation of the common bile duct and congenital diverticulum of the hepatic duct is reported. The etiology and classification are briefly discussed and a radiological approach is recommended.