HLA-B*15 Is Associated With SARS-CoV-2 Infection in a Brazilian Population.

Studies have suggested an association between polymorphisms in class I genes of the major histocompatibility complex, specifically the human leukocyte antigen (HLA), and susceptibility to SARS-CoV-2. To explore this, 135 individuals with positive serological tests for SARS-CoV-2 were recruited. All the samples were collected before the advent of vaccines, avoiding immunization effects.

Supplemental oxygen prescriptions after hospitalization for coronavirus disease 2019.

Background: The role of home oxygen therapy for patients recovering from Coronavirus Disease 2019 (COVID-19) pneumonia, characterized by impaired gas exchange, is not well-defined.

Objectives: To compare the characteristics, duration, odds of receiving, and continuing to receive home oxygen prescriptions between patients discharged home after COVID-19 pneumonia hospitalization and those discharged after non-COVID-19 pneumonia.

Methods: From April 2020 to March 2021, 52,951 patients with COVID-19 pneumonia (53.

Production of dendritic cell vaccines using different methods with equivalent results: Implications for emerging centers.

Introduction: Dendritic cell (DC) vaccines have demonstrated good efficacy in preventing relapse and in increasing survival of patients affected by a variety of both solid and hematological tumors. Most protocols used to generate these cells involve the automated separation of peripheral blood monocytes from patients. This approach requires specialized equipment, which elevates the cost of this type of therapy, potentially limiting the widespread access to patients.

Ethics, COVID-19 and nursing vulnerability: analysis of photographs released by the media.

Objectives: to analyze nursing vulnerability through photos released by the media amidst the COVID-19 pandemic.

Methods: a documentary study, with a qualitative approach. The object of analysis were photographic images selected between January 2020 and March 2021, published by the main news portals in countries such as Brazil, the United States, France, Spain, England and Germany.

Description of a new species of Laelaspis Berlese (Acari: Mesostigmata: Laelapidae) from Brazil, with a key to the species of the Western Hemisphere.

Laelaspis loeckii Duarte Moreira sp. nov. is described based on the morphology of adult females and males collected from soil in a survey carried out in southern Brazil, in the temperate Pampa biome.

Selection of plasma donors for the production of anti-SARS-CoV-2 immunoglobulin-based therapies: Strategies for quantitative antibody measurements.

Even after two years of the pandemic, a completely effective treatment against SARS-CoV-2 has not yet been established. Considering this fact and the emergence of successive new viral variants, the development of therapies based on natural polyclonal antibodies recovered from convalescent plasma remains relevant. This study presents a comparison between different methods of screening antibodies in samples of 41 individuals previously diagnosed with COVID-19.

Poly (L-Lactic Acid) Cell-Laden Scaffolds Applied on Swine Model of Tracheal Fistula.

Introduction: Tracheal fistula (TF) treatments may involve temporary orthosis and further ablative procedures, which can lead to infection. Thus, TF requires other therapy alternatives development. The hypothesis of this work was to demonstrate the feasibility of a tissue-engineered alternative for small TF in a preclinical model.

Effects of Climatic Change on the Potential Distribution of Species (Diptera: Sciaridae) of Economic Importance.

species (Sciaridae) are responsible for significant economic losses in greenhouse production (e.g., mushrooms, strawberries, and nurseries).

Bioethics in Childbirth Care: Protocol for a Scoping Review.

Background: Ensuring women's rights during childbirth care based on humanized and bioethical principles results in better quality of care and patient safety and provides positive childbirth experiences.

Objective: We aim to explore the available evidence on the application of bioethical principles in the general context of childbirth care.

Methods: Our scoping review will follow the Joanna Briggs Institute Reviewer's Manual.

Rapid clinical recovery of a SARS-CoV-2 infected common variable immunodeficiency patient following the infusion of COVID-19 convalescent plasma.

Background: Common variable immunodeficiency is the most prevalent symptomatic primary immunodeficiency in adults. Affected patients fail to mount an appropriate humoral response against community acquired infectious diseases and recent reports have provided data supporting the increased susceptibility of these patients to severe SARS-CoV-2 infections. In this context, the infusion of COVID-19 convalescent plasma could represent an effective therapeutic strategy.

Novel Non-Coding Transcript in Locus, LncNR4A3, Regulates RNA Processing Machinery Proteins and Expression.

is a key tumor suppressor in myeloid malignancy, mice lacking both and family member rapidly develop lethal acute myeloid leukemia (AML). We identified a long non-coding transcript in the locus and pursued the characterization of this anonymous transcript and the study of its role in leukemogenesis. We characterized this novel long non-coding transcript as a sense polyadenylated transcript.

Compatibility of pesticides used in strawberry crops with predatory mites Stratiolaelaps scimitus (Womersley) and Cosmolaelaps brevistilis (Karg).

Stratiolaelaps scimitus (Womersley) and Cosmolaelaps brevistilis (Karg) (Acari: Laelapidae) are predatory mites of soil-inhabiting pests, mainly small insects. Fungus gnats fly species are found in greenhouse strawberry production and may be controlled with predatory mites, being important to know their compatibility with the pesticides used in strawberry crops. In this study, the compatibility of seven commercial pesticides used in strawberry cultivation with the predatory mites S.

BRD4 Inhibition Enhances Azacitidine Efficacy in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell-based disorders characterized by ineffective hematopoiesis, increased genomic instability and a tendency to progress toward acute myeloid leukemia (AML). MDS and AML cells present genetic and epigenetic abnormalities and, due to the heterogeneity of these molecular alterations, the current treatment options remain unsatisfactory. Hypomethylating agents (HMA), especially azacitidine, are the mainstay of treatment for high-risk MDS patients and HMA are used in treating elderly AML.

Up-regulation of SPINT2/HAI-2 by Azacytidine in bone marrow mesenchymal stromal cells affects leukemic stem cell survival and adhesion.

The role of tumour microenvironment in neoplasm initiation and malignant evolution has been increasingly recognized. However, the bone marrow mesenchymal stromal cell (BMMSC) contribution to disease progression remains poorly explored. We previously reported that the expression of serine protease inhibitor kunitz-type2 (SPINT2/HAI-2), an inhibitor of hepatocyte growth factor (HGF) activation, is significantly lower in BMMSC from myelodysplastic syndromes (MDS) patients compared to healthy donors (HD).

C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: case report.

Background: Morbidity associated with monoclonal gammopathy of renal significance is high due to the severe renal lesions and the associated systemic alterations. Accordingly, early diagnosis is fundamental, as is stopping the clonal production of immunoglobulins using specific chemotherapy.

Case Presentation: A 75-year-old man with chronic renal disease of unknown origin since 2010 experienced rapid worsening of renal function over a period of 6 mos.

Suitability of edaphic arthropods as prey for Proctolaelaps bickleyi and Cosmolaelaps brevistilis (Acari: Mesostigmata: Melicharidae, Laelapidae) under laboratory conditions.

Soils are often complex habitats inhabited by a wide range of organisms, some harmful to plants and others beneficial, for example by attacking harmful organisms. Beneficial organisms include predatory mites, some of which have been commercialized for biological control of pest insects and mites. The objective of this work was to evaluate under laboratory condition the suitability of representative soil insect and mite pests, especially Aceria tulipae (Keifer), as prey to the soil-inhabiting predatory mites Proctolaelaps bickleyi (Bram) and Cosmolaelaps brevistilis (Karg).

CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells.

CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown. By inhibition of CXCR4 and/or CXCR7, we showed that CXCR7 participates in normal CD34 and U937 cell migration and prevents downregulation of CXCR4 by CXCL12 stimulation. In addition, CXCR7 contributes to homing of acute myeloid leukemia and normal progenitor cells to the bone marrow and spleen of NOD/SCID mice.