Publications by authors named "Duane W Wong"
Article Synopsis
- - X-linked hyper-IgM syndrome (XHM) is an immune deficiency due to mutations in the CD40 ligand, and researchers tested a CD40 agonist antibody, CP-870,893, on two patients with biliary Cryptosporidiosis.
- - CP-870,893 successfully activated B cells and other immune cells in the lab, and when used on patients, it reduced white blood cell levels in their blood and decreased stool shedding of the parasite.
- - Although initial results were promising, including T cell activation, issues arose as patients' immune responses and oocyst shedding returned after stopping the treatment, suggesting further research into CD40 agonists like CP-870,893 is needed for XHM patients
X-linked hyper IgM syndrome (XHM) is a combined immune deficiency disorder caused by genetic alterations in CD40 ligand. The purpose of this study was to investigate the safety and efficacy of recombinant CD40 ligand (rCD40L) in the treatment of the disease. Three children were administered rCD40L subcutaneously 3 times per week at 0.
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