Synopsis of recent research by authors named "Duane Burnett"
- Duane Burnett's recent research primarily focuses on the discovery and development of small molecule modulators targeting gamma secretase for the treatment of Alzheimer's disease, showcasing compounds like oxadiazines and spirocyclic sulfones that demonstrate significant in vitro and in vivo efficacy.
- His studies also explore enhancers of cellular progranulin release, revealing innovative compounds that improve safety profiles and potentiate neuronal functions, which could have implications for neurodegenerative disorders.
- Additionally, he has contributed to the identification of novel TRPML1 agonists, emphasizing their potential as tool compounds for advancing studies on cellular signaling pathways and disease mechanisms affecting the central nervous system.
