Inhibitory Effect of Aconitine on Colorectal Cancer Malignancy via Inducing Apoptosis and Suppression of Cell Motion.

Background/aims: The incidence of colorectal cancer (CRC) has been increasing in recent years worldwide. Aconitine is a diester diterpenoid alkaloid that exhibits an antitumor role in several cancers. Nevertheless, it remains unclear whether aconitine also has antitumor activity in CRC.

Manipulating Zn Metal Texture with Guided Zincophilic Sites via Electrochemical Stripping for Dendrite-Free Zn Anodes.

Constructing a three-dimensional (3D) structure along with Zn (002) texture selective exposure is a promising strategy to tackle the issues faced by Zn metal anodes. Herein, for the first time, we proposed an electrochemical stripping strategy to achieve controlled modification of the texture and microstructure of zinc foils in one step, building a hierarchical structure with (002) texture preferred exposed Zn (SZ). The SZ with favorable zincophilic properties not only can reduce the concentration polarization at the interface but also allow Zn to grow horizontally on the edge of the (002) texture by guiding the adsorption sites for Zn.

LncRNA ZNF667-AS1 Targets miR-523-3p/KIF5C Axis to Hinder Colon Cancer Progression.

LncRNA ZNF667-AS1 plays an important role in the carcinogenesis and progression of various cancers. However, their role in colon cancer (CC) remains unclear. The expression of ZNF667-AS1, KIF5C, and miR-523-3p in CC cells and tissues was analyzed using RT-qPCR and western blotting.

Construction of Cu-N coordination into natural biopolymer lignin backbone for highly efficient and selective removal of cationic dyes.

Here, a Cu-doped lignin-based adsorbent (Cu-AL) was fabricated via the amination and Cu-doping of industrial alkali lignin for massive and selective adsorption of cationic dyes azure B (AB) and saffron T (ST). The Cu-N coordination structures endowed Cu-AL with stronger electronegativity and higher dispersity. Through the electrostatic attraction, π-π interaction, H-bonding, and Cu coordination, the adsorption capacities of AB and ST reached up to 1168 and 1420 mg g, respectively.

A Reverberation Suppression Method Based on the Joint Design of a PTFM Waveform and Receiver Filter.

Transmitting waveform design and signal processing method optimization are effective ways to improve a sonar system's detection performance. In this study, the spectrum and ambiguity function characteristics of pulse trains of frequency modulation (PTFM) signals were deduced and analyzed to address the problem of serious reverberation interference in the detection of low-speed targets in shallow water environments. The action mechanisms of PTFM signal parameters on the comb spectrum and bed of nails ambiguity function were identified.

Comprehensive Analysis of Ferroptosis- and Immune-Related Signatures to Improve the Prognosis and Diagnosis of Kidney Renal Clear Cell Carcinoma.

Background: Almost 40% of patients with kidney renal clear cell carcinoma (KIRC) with advanced cancers eventually develop to metastases, and their 5-year survival rates are approximately 10%. Aberrant DNA methylations are significantly associated with the development of KIRC. The aim of our present study was to identify suitable ferroptosis- and immune-related (FI) biomarkers correlated with aberrant methylations to improve the prognosis and diagnosis of KIRC.

Tremella-like Hydrated Vanadium Oxide Cathode with an Architectural Design Strategy toward Ultralong Lifespan Aqueous Zinc-Ion Batteries.

Rechargeable aqueous zinc-ion batteries (ZIBs) are promising systems for energy storage due to their operational safety, low cost, and environmental friendliness. However, the development of suitable cathode materials is plagued by the sluggish dynamics of Zn with strong electrostatic interaction. Herein, an Al-doped tremella-like layered AlVO·1.

Prognostic significance of microRNA-203 in cholangiocarcinoma.

MircroRNA functions as a tumor suppressor or a promoter in cholangiocarcinoma (CCA). Researchers have found that miR-203 functioned as tumor suppressor in many types of cancer. However, the role of miR-203 that plays in CCA remains to be clarified.