LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy.

Background: Colorectal cancer (CRC) is a highly malignant and aggressive gastrointestinal tumor. Due to its weak immunogenicity and limited immune, cell infiltration lead to ineffective clinical outcomes. Therefore, to improve the current prophylaxis and treatment scheme, offering a favorable strategy efficient against CRC is urgently needed.

Contrastive learning with transformer for adverse endpoint prediction in patients on DAPT post-coronary stent implantation.

Background: Effective management of dual antiplatelet therapy (DAPT) following drug-eluting stent (DES) implantation is crucial for preventing adverse events. Traditional prognostic tools, such as rule-based methods or Cox regression, despite their widespread use and ease, tend to yield moderate predictive accuracy within predetermined timeframes. This study introduces a new contrastive learning-based approach to enhance prediction efficacy over multiple time intervals.

AM fungus plant colonization rather than an Epichloë endophyte attracts fall armyworm feeding.

Most cold-season grasses can be colonized by belowground arbuscular mycorrhizal (AM) fungi and foliar grass endophytes (Epichloë) simultaneously while also be attacked by insect herbivores. The colonization of AM fungi or the presence of grass endophytes is associated with increased resistance by the host plant. However, studies on how these two symbionts affect host plants and mitigate insect pest attack are currently lacking.

Cross-Modal Collaboration and Robust Feature Classifier for Open-Vocabulary 3D Object Detection.

The multi-sensor fusion, such as LiDAR and camera-based 3D object detection, is a key technology in autonomous driving and robotics. However, traditional 3D detection models are limited to recognizing predefined categories and struggle with unknown or novel objects. Given the complexity of real-world environments, research into open-vocabulary 3D object detection is essential.

The functional regulation between extracellular vesicles and the DNA damage responses.

The DNA damage response (DDR) is a crucial regulatory mechanism for the survival of organisms, and irregularity of DDR may contribute to the development of various diseases, including tumors, making it is a prominent topic in therapeutic research. Extracellular vesicles (EVs), as important mediators of intercellular communication, have been extensively studied in recent years. Notably, an increasing number of studies have revealed a strong connection between DDR and EVs.

A unique achalasia patient complicated by neuropathies associated with nutritional deficiencies.

This paper reported a rare case of achalasia patient postoperatively experiencing a series of neurologic symptoms, diagnosed as severe B vitamin deficiencies caused by central and peripheral damage.

Clinical Analysis of MOG Antibody-Associated Disease Overlapped With Anti-NMDA Receptor Encephalitis: A Long-Term Retrospective Study.

To summarise the clinical characteristics, radiological features, treatments and prognosis of patients with myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) overlapped with NMDA receptor (NMDAR) encephalitis. We retrospectively analysed patients who exhibited dual positivity for MOG antibodies and NMDAR antibodies in serum/CSF from Jan 2018 to Jun 2023. Ten patients with MOGAD and NMDAR encephalitis were enrolled.

Synergistically Halogenated and Methoxylated Thiophene Additive Enables High-Performance Organic Solar Cells.

Morphology control plays a key role for improving efficiency and stability of bulk heterojunctions (BHJ) organic solar cells (OSCs). Halogenation and methoxylation are two separate ways successfully adopted in additives for morphology optimization. In this work, these two strategies are combined together.

Network pharmacology, molecular docking, and experimental verification reveal the mechanism of Yi-Shen-Hua-Shi granules treating acute kidney injury.

Ethnopharmacological Relevance: Yi-Shen-Hua-Shi granules (YSHSG) have been shown to improve kidney function in various renal disorders, which are characterized by the sudden decline and impairment of kidney function.

Aim Of The Study: To investigate the precise mechanisms and targets of YSHSG in combating sepsis-induced AKI.

Materials And Methods: Through network pharmacology, the active ingredients, main target proteins, and related signaling pathways of YSHSG in the treatment of sepsis-induced AKI were predicted.

Trajectories of Chinese adolescent depression before and after COVID-19: A cross-temporal meta-analysis with segmented regression.

Background: The COVID-19 pandemic has had a profound impact on adolescent mental health, particularly in China. However, there is a lack of research examining the trends in depressive symptom levels among Chinese adolescents before and after the pandemic. This study aims to investigate the changes in depressive symptom levels among Chinese adolescents pre- and post-pandemic and to identify the factors influencing these changes.

[Asperosaponin VI alleviates TNBS-induced Crohn's disease-like colitis in mice by reducing intestinal epithelial cell apoptosis via inhibiting the PI3K/AKT/NF-κB signaling pathway].

Objectives: To investigate the effects of asperosaponin VI (AVI) on intestinal epithelial cell apoptosis and intestinal barrier function in a mouse model of Crohn's disease (CD)-like colitis and explore its mechanisms.

Methods: Male C57BL/6 mice with TNBS-induced CD-like colitis were treated with saline or AVI (daily dose 150 mg/kg) by gavage for 6 days. The changes in body weight, colon length, DAI scores, and colon pathologies of the mice were observed, and the expressions of inflammatory factors and tight injunction proteins were detected using ELISA and RT-qPCR.

Long-term follow-up of combination therapy with pembrolizumab and anlotinib in thoracic SMARCA4-deficient undifferentiated tumor: a case report and molecular features.

Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UTs), recently recognized as a rare malignancy described in the 5th edition of the World Health Organization Classification of Tumors, are characterized by an inactivating mutation in SMARCA4, most commonly found in the mediastinum of male smokers. Despite the aggressive nature and poor prognosis associated with these tumors, which have a median survival time of approximately 4-7 months, no standardized treatment guidelines are currently established. There are currently no reported cases of extended progression-free survival (PFS) in SMARCA4-UT patients treated with surgery and immunotherapy.

Effect of AM fungi on the growth and powdery mildew development of Astragalus sinicus L. under water stress.

Arbuscular mycorrhizal (AM) fungi are widely existing soil microorganisms that form symbiotic relationships with most terrestrial plants. They are important for enhancing adversity resistance, including resistance to disease and water stresses. Nevertheless, it is not clear whether the benefits can be maintained in regulating the occurrence of plant diseases under drought, flooding stress and during water restoration.

Indole-3-lactic acid derived from tryptophan metabolism alleviates the sFlt-1-induced preeclampsia-like phenotype via the activation of aryl hydrocarbon receptor.

Aims: Preeclampsia (PE) is an unusual multisystem condition that occurs during pregnancy and is characterized by maternal endothelial dysfunction and damage to various organs. The catabolism of L-tryptophan (Trp) is involved in various biological activities, including healthy pregnancy. Our previous work revealed that PE significantly elevated the concentration of indole-3-lactic acid (ILA), a Trp derivative, during the third trimester of pregnancy.

EMC2 suppresses ferroptosis via regulating TFRC in nasopharyngeal carcinoma.

Background: Nasopharyngeal carcinoma (NPC) is an epithelial malignancy with poorly understood underlying molecular mechanisms. Ferroptosis, a form of programmed cell death, is not fully elucidated in NPC.

Method: We conducted quantitative proteomics to detect dysregulated proteins in NPC tissues.

Effect of pulmonary rehabilitation training on postoperative recovery in lung cancer patients undergoing thoracoscopic partial pulmonary resection: a meta-analysis.

Objective: To systematically analyze the impact of pulmonary rehabilitation (PR) on postoperative recovery of lung cancer patients undergoing thoracoscopic partial pulmonary resection.

Methods: This study has been registered with PROSPERO (CRD42024574965). A comprehensive search was conducted in PubMed, The Cochrane Library, Embase, Web of Science and CINAHL for literature on the effects of PR on postoperative rehabilitation in lung cancer patients undergoing thoracoscopic partial pulmonary resection, up to May 2024.

Unsupervised deep learning-based medical image registration: a survey.

In recent decades, medical image registration technology has undergone significant development, becoming one of the core technologies in medical image analysis. With the rise of deep learning, deep learning-based medical image registration methods have achieved revolutionary improvements in processing speed and automation, showing great potential, especially in unsupervised learning. This paper briefly introduces the core concepts of deep learning-based unsupervised image registration, followed by an in-depth discussion of innovative network architectures and a detailed review of these studies, highlighting their unique contributions.

Fully automated MRI-based convolutional neural network for noninvasive diagnosis of cirrhosis.

Objectives: To develop and externally validate a fully automated diagnostic convolutional neural network (CNN) model for cirrhosis based on liver MRI and serum biomarkers.

Methods: This multicenter retrospective study included consecutive patients receiving pathological evaluation of liver fibrosis stage and contrast-enhanced liver MRI between March 2010 and January 2024. On the training dataset, an MRI-based CNN model was constructed for cirrhosis against pathology, and then a combined model was developed integrating the CNN model and serum biomarkers.

Effects of unilateral and bilateral contrast training on the lower limb sports ability of college basketball players.

The purpose of this study was to compare the impact of unilateral (U) and bilateral (B) contrast training on lower limb explosiveness, agility, and balance in college basketball athletes. Twenty male college basketball players were randomly assigned to either a unilateral group (U, n = 10) or a bilateral group (B, n = 10). Both groups underwent an 8week strength training program, with sessions held twice a week.

DMT1 Maintains Iron Homeostasis to Regulate Mitochondrial Function in Porcine Oocytes.

Iron plays critical roles in many cellular functions, including energy production, metabolism, and cell proliferation. However, the role of iron in maintaining oocyte quality remains unclear. In this study, DMT1 was identified as a key iron transporter during porcine oocyte maturation.

E-beam fluorinated CVD graphene:XPS study on stability and NHadsorption doping effect.

Graphene exhibits promise in gas detection applications despite its limited selectivity. Functionalization with fluorine atoms offers a potential solution to enhance selectivity, particularly towards ammonia (NH+) molecules. This article presents a study on electron-beam fluorinated graphene (FG) and its integration into gas sensor platforms.

Imidazole Encapsulation Enabled by Confinement for I and CHI Coremoval.

Nitrogen-rich small molecules are frequently doped into porous materials to enhance their iodine adsorption properties. To explore how imidazole confinement in metal-organic frameworks (MOFs) affects iodine adsorption, we obtained a UiO-66-based composite by embedding imidazole in UiO-66 pores via solid-phase adsorption (Im@UiO-66). Characterization confirmed that imidazole was successfully confined within the UiO-66 pores, with each unit of UiO-66 accommodating up to 27 imidazole molecules.

Accelerometer-derived movement behaviours and risk of mortality among individuals with pre-existing depression: prospective cohort study.

Background: Evidence is largely limited regarding the extent to which abnormal behavioural profiles, including physical inactivity, sedentary behaviour and inadequate sleep duration, impact long-term health conditions in individuals with pre-existing depression.

Aims: To investigate the associations between accelerometer-derived daily movement behaviours and mortality in individuals with pre-existing depression.

Method: Between 2013 and 2015, a total of 10 914 individuals with pre-existing depression were identified from the UK Biobank through multiple sources including self-reported symptoms, records of antidepressant usage and diagnostic recording based on the 10th Revision of the International Classification of Diseases (ICD-10) codes F32-F33.