Publications by authors named "Duan Ruonan"

Persulfate-based advanced oxidation processes (PS-AOPs) catalyzed by carbon-based catalysts are promising for removing organic pollutants via radical/non-radical pathways. However, the activation efficiency of peroxymonosulfate (PMS) or peroxydisulfate (PDS) usage and the reaction mechanism remain insufficiently understood. In this study, the effects of PMS/PDS dosage on the degradation of bisphenol A (BPA, 10 mg/L) were evaluated using N-doped biochar (N-BC, 0.

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Background: Patients with liver cirrhosis are universally malnourished and the nocturnal snacks intervention is the currently recommended nutritional intervention for patients with liver cirrhosis. Body composition is an important indicator for the assessment of nutritional conditions. We investigated the effects of nocturnal snacks (200 kcal/day) for 3 months on body composition in patients with liver cirrhosis.

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  • Acute ischemic stroke (AIS) leads to immune responses and neuroinflammation, which worsen brain injury, and this study explores histone lactylation as a possible factor in this process.
  • Researchers used specific models to examine how microglial histone lactylation affects ischemia-reperfusion injury, finding that increased lactate levels post-AIS correlated with higher histone lactylation and neuroinflammation, especially when SMEK1 expression in microglia was low.
  • The study concludes that SMEK1 is a key regulator of histone lactylation, suggesting it could be a promising target for treatments aimed at reducing neuroinflammation and improving recovery after a stroke.
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Aims: To investigate the effect of alcohol consumption on the clinical symptoms in a cohort of Progressive supranuclear palsy (PSP) patients.

Methods: We conducted a cross-sectional study focusing on possible and probable PSP patients in Qilu Hospital of Shandong University. Diagnoses and clinical phenotypes were confirmed using the 2017 Movement Disorder Society criteria and the Multiple Allocations eXtinction (MAX) rules.

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  • Lafora disease (LD) is a serious genetic disorder leading to seizures, myoclonus, behavioral changes, and eventual dementia, caused primarily by mutations in the EPM2A and NHLRC1 genes.
  • This study focuses on a patient with LD and identifies specific intronic mutations in EPM2A that impact mRNA splicing, leading to the disease's symptoms.
  • The research highlights the importance of genetic testing in diagnosing LD and expands the understanding of how certain mutations in non-coding regions can contribute to the condition.
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During the COVID-19 pandemic, the online delivery model became the primary mode of education. With multiple pressures on society and families, mental health issues for parents have become particularly pronounced. Most of the current research has focused on the psychological state of education practitioners and children, with little attention to parents' mental health issues.

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Suppressor of Mek1 (Smek1) is a regulatory subunit of protein phosphatase 4. Genome-wide association studies have shown the protective effect of SMEK1 in Alzheimer's disease (AD). However, the physiological and pathological roles of Smek1 in AD and other tauopathies are largely unclear.

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Objective: Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, and type 2 diabetes (T2DM) and PD are influenced by common genetic and environmental factors. Mitochondrial dysfunction and inflammation are common pathogenic mechanisms of both diseases. However, the close association between PD and T2DM and the specific relationship between them are not yet clear.

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Neurodegenerative diseases, characterized by abnormal deposition of misfolded proteins, often present with progressive loss of neurons. Chronic neuroinflammation is a striking hallmark of neurodegeneration. Microglia, as the primary immune cells in the brain, is the main type of cells that participate in the formation of inflammatory microenvironment.

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  • Alzheimer's disease (AD) is a neurodegenerative disorder defined by abnormal protein cleavage and aggregation, primarily involving beta-amyloid (Aβ) plaques and neurofibrillary tangles formed by hyperphosphorylated Tau.
  • Recent findings highlight the critical role of vascular dysfunction, specifically the loss of pericytes, in the development of AD; these cells are essential for maintaining blood-brain barrier integrity and clearing toxic substances from the brain.
  • Understanding the interactions between pericytes and Aβ can illuminate the disease mechanism and help identify potential new therapeutic targets to prevent or treat AD.
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Neuroinflammation is crucial in the onset and progression of dopaminergic neuron loss in Parkinson's disease (PD). We aimed to determine whether 3-N-Butylphthalide (NBP) can protect against PD by inhibiting the cyclic GMP-AMP synthase (cGAS)stimulator of interferon genes (STING) pathway and the inflammatory response of microglia. MitoSOX/MitoTracker/Hoechst staining was used to detect the levels of mitochondrial reactive oxygen species (ROS) in BV2 cells.

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Anti-DNER antibody is associated with paraneoplastic cerebellar degeneration (PCD) and Hodgkin's disease (HD). However, recent studies reported cases absence of HD and that non-tumor anti-DNER antibody-associated ataxia was not well characterized. We present a case of acute cerebellar ataxia and nystagmus with detected anti-DNER antibody.

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The "hot cross bun" sign (HCBs) is a cruciform hyperintensity on T2-weighted imaging within the pons initially found in patients diagnosed as multiple system atrophy. However, recent findings have broadened the disease spectrum presented with HCBs. Here is a case report at an academic medical center.

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Nowadays, strained quantum structures have been widely used in various light-emitting devices with a variety of compounds for progressive applications. However, the lattice-mismatch-induced strains in the materials would cause a problem of polarization dependence for polarization-independent optical applications. To address this issue, in this paper we propose a novel ultra-broadband depolarization mechanism and approach based on a directly-coupled well-wire-hybrid nanostructure.

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  • Alpha-synuclein copy number variations (CNV) are linked to both familial and sporadic cases of Parkinson's disease (PD), with specific cases identified through whole-exome sequencing.
  • Three cases of PD with duplications were documented, revealing de novo CNV regions in one patient and a larger repeated region in two familial cases.
  • The study found that aggressive behavior and cognitive decline were more pronounced in patients with CNV, while younger onset was observed in offspring compared to parents, highlighting important implications for diagnosis and genetic counseling in PD.
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  • Methylglyoxal (MGO) is a metabolite linked to glycolysis and has been found to accumulate in autoimmune diseases, but its role remains understudied.
  • In experiments, elevated MGO levels were observed in activated immune cells, and its treatment reduced inflammation in the spinal cords of EAE mice, improving symptoms.
  • MGO inhibited pro-inflammatory responses in microglia, reduced their recruitment of lymphocytes, and suppressed glycolysis by altering glucose transporter expression, ultimately acting as an immunosuppressive agent through the NRF2-IκBζ pathway.
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Although traditional quantum-confined nanostructures e.g. regular quantum wells or quantum dots have achieved huge success in the field of semiconductor lasers for past decades, these traditional nanostructures are encountering the difficulty of enhancing device performance to a higher level due to their inherent gain bottleneck.

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Objective: To investigate the prospective association between sugar-sweetened beverage intakes and age at menarche among Chinese girls.

Methods: Based on China Health and Nutrition Survey(CHNS) from 2004 to 2015, 293 girls aged 7-16 years with both data on sugar-sweetened beverage intake 1-5 years before menarche and age of menarche were included in the present study. Multivariate linear regression analysis and Logistic regression analysis were used to explore the influence of the sugar-sweetened beverage consumption on menarcheal age of Chinese girls.

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  • NIID is a complex disease with varying symptoms, making early diagnosis difficult, and PSP-like symptoms had not previously been associated with it.
  • A 58-year-old man initially diagnosed with probable PSP showed symptoms like Parkinsonism and gaze problems, but further testing revealed he actually had NIID due to specific genetic expansions and skin biopsy findings.
  • This case highlights the need for clinicians to consider NIID as a possible diagnosis when faced with PSP-like symptoms, even in the absence of typical imaging indicators.
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Background: Diet quality in early childhood has a long-term impact on health outcomes. However, there are scarce dietary indexes for Chinese preschool children, and the existing indexes had limited validity and reliability. This study thus aimed to develop a dietary index for preschool children based on the Chinese Dietary Guideline and Chinese Dietary Reference Intakes and to assess their overall diet quality using the China Health and Nutrition Survey (CHNS).

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It is always a challenge how to overcome speckle noise interference in the phase reconstruction for coherent digital holography (CDH) and its application, as this issue has not been solved well so far. In this paper, we are proposing an enhanced anti-speckle deep neural unwrapping network (E-ASDNUN) approach to achieve high quality of absolute phase reconstruction for CDH. The method designs a special network-based noise filter and embeds it into a deep neural unwrapping network to enhance anti-noise capacity in the image feature recognition and extraction process.

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Metal/metal oxide catalysts reveal unique CO adsorption and hydrogenation properties in CO electroreduction for the synthesis of chemical fuels. The dispersion of active components on the surface of metal oxide has unique quantum effects, significantly affecting the catalytic activity and selectivity. Catalyst models with 25, 50, and 75% Ag covering on ZrO, denoted as Ag/(ZrO), Ag/(ZrO), and Ag/(ZrO), respectively, were developed and coupled with a detailed investigation of the electronic properties and electroreduction processes from CO into different chemical fuels using density functional theory calculations.

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Objective: Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Mitochondrial dysfunction is suspected as one of the pathogenic mechanisms of PD. Growth/differentiation Factor-15 (GDF15) has been reported to affect mitochondrial function in PD.

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