Personal preferences for Personalised Trials among patients with chronic diseases: an empirical Bayesian analysis of a conjoint survey.

Objective: To describe individual patient preferences for Personalised Trials and to identify factors and conditions associated with patient preferences.

Design: Each participant was presented with 18 conjoint questions via an online survey. Each question provided two choices of Personalised Trials that were defined by up to eight attributes, including treatment types, clinician involvement, study logistics and trial burden on a patient.

[An ecological stoichiometry model based on the size of Nitraria tangutorum].

Ecological stoichiometry provides a new method for understanding the characteristics, driving forces and mechanisms of C, N and P coupled cycles. However, there are few reports on the variation in ecological stoichiometry of plants during their growth. In this study, we fitted the total elemental mass of different module based on the size of Nitraria tangutorum, and derived the ecological stoichiometry models of different module and whole ramet by measuring the biomass and nutrient concentrations of the current-year stems in 2017, 2-year-old stems, more than 2-year-old stems, leaves, roots and layerings of N.

Preparedness and disinfection of anesthetic equipment in COVID-19.

• Standards for perioperative supply and equipment precaution for COVID-19 have not been detailed. • Systematically introduces sufficiently preoperative and postoperative equipment precaution. • The sterilization of disassembled anesthesia machine according to high-temperature resistance.

Novel fluorescent probe for the ratiometric detection of β-galactosidase and its application in fruit.

A ratiometric fluorescent probe (Probe 1) was developed for the sensitive detection of β-galactosidase (β-gal) activity. Probe 1 detected β-gal activity in the range 0-1.0 U/mL, with a limit of detection of 0.

NSM00158 Specifically Disrupts the CtBP2-p300 Interaction to Reverse CtBP2-Mediated Transrepression and Prevent the Occurrence of Nonunion.

Carboxyl-terminal binding proteins (CtBPs) are transcription regulators that control gene expression in multiple cellular processes. Our recent findings indicated that overexpression of caused the repression of multiple bone development and differentiation genes, resulting in atrophic nonunion. Therefore, disrupting the CtBP2-associated transcriptional complex with small molecules may be an effective strategy to prevent nonunion.

Photocatalysis and degradation products identification of deoxynivalenol in wheat using upconversion nanoparticles@TiO composite.

Deoxynivalenol (DON) is one of the most common contaminants of cereal grains. Efficient and environmental-friendly technology to eliminate DON is important for food safety and environmental protection. In this work, upconversion nanoparticles (UCNP) coated with titanium dioxide (TiO) photocatalysts were synthesized.

Fluorometric determination of acetamiprid using molecularly imprinted upconversion nanoparticles.

This paper describes the fabrication of an imprinted fluorescent nanoprobe based on SiO-coated NaYF: Yb, Er upconversion nanoparticles (UCNP) encapsulated with a molecularly imprinted polymer (MIP) for determination of acetamiprid. The fluorescent MIP nanoprobe was prepared using UCNP as the material for fluorescence signal readout, acetamiprid as template molecule, methylacrylic acid (MAA) as functional monomer, and ethyleneglycol dimethacrylate (EGDMA) as cross-linking agent. The molecular imprinting layers were immobilized on the surface of the UCNP@SiO by polymerization which occurred between the double bonds.

Surface-enhanced Raman spectroscopic-based aptasensor for Shigella sonnei using a dual-functional metal complex-ligated gold nanoparticles dimer.

Herein, we constructed an aptamer-based sensor for the sensitive and highly specific detection of Shigella sonnei via surface enhanced Raman spectroscopy (SERS) analysis. A composite material integrated of the Raman active 4-MBA ligand of the Eu-complex and citrate-stabilized Au nanoparticles (cit-Au NPs) was synthesized and served as both active substrate and Raman reporter. Aptamers targeted to S.

Life cycle assessment of anaerobic digestion of pig manure coupled with different digestate treatment technologies.

The direct use of digestate on farmlands as soil amendment is becoming an uneconomic option for farmers. Moreover, there are serious environmental concerns about its oversupply in regions with intensive biogas plants. Downstream technologies, offering innovative upcycling methods to handle huge amounts of digestate, have absorbed great interest in this context.

A SERS aptasensor for simultaneous multiple pathogens detection using gold decorated PDMS substrate.

An aptamer-based sensitive method was developed here for detection of multiple foodborne pathogens in food matrix by surface-enhanced Raman scattering (SERS) technology. Polydimethylsiloxane (PDMS) film was first prepared and then coated with gold nanoparticles (AuNP) to act as an active substrate for the enhancement of Raman scattering. The as-prepared Au-PDMS film was functionalized with specific pathogen aptamers (Apt) to capture the targets.

Elongation during segmentation shows axial variability, low mitotic rates, and synchronized cell cycle domains in the crustacean, .

Background: Segmentation in arthropods typically occurs by sequential addition of segments from a posterior growth zone. However, the amount of tissue required for growth and the cell behaviors producing posterior elongation are sparsely documented.

Results: Using precisely staged larvae of the crustacean, , we systematically examine cell division patterns and morphometric changes associated with posterior elongation during segmentation.

Artemisinin Attenuated Atherosclerosis in High-Fat Diet-Fed ApoE-/- Mice by Promoting Macrophage Autophagy Through the AMPK/mTOR/ULK1 Pathway.

Artemisinin is an endoperoxide sesquiterpene lactone from Artemisia annua L with multiple beneficial effects, including anti-inflammation, antioxidant, and vascular protection. Recent studies have found that inflammation along with autophagy deficiency in macrophages is the possible reason for foam cell accumulation in the intima, which leads to atherosclerotic plaque formation. The primary aims of this study were to explore the inhibiting effect of artemisinin on atherosclerosis in high-fat diet-fed ApoE mice and investigate the probable mechanism.

The clinicopathological and genetic features of ovarian diffuse large B-cell lymphoma.

Ovarian lymphoma, whether a primary or secondary condition, is very rare. Little is known about its genetic aberrations. Here, we reviewed the clinical, morphological and immunohistochemical characteristics of nine ovarian diffuse large B-cell lymphoma (DLBCL) cases and performed fluorescence in situ hybridisation (FISH) analysis to detect MYC, BCL2 and BCL6 translocations.

Characteristics of patients with autoimmune haemolytic anaemia secondary to lymphoproliferative disorder: A single-centre retrospective analysis.

Autoimmune haemolytic anaemia (AIHA) is a kind of autoimmune diseases characterized by autoantibodies which produced and secreted by abnormal activated B lymphocytes directed against red blood cells (RBC). Study reveals that about 50% AIHA mainly occurs secondary to lymphoproliferative disorders (LPD) and autoimmune diseases. In this study, we aim to explore the characteristics of patients with AIHA secondary to LPD.

Pancreatic Ductal Adenocarcinoma: Machine Learning-Based Quantitative Computed Tomography Texture Analysis For Prediction Of Histopathological Grade.

Purpose: To assess the performance of combining computed tomography (CT) texture analysis with machine learning for discriminating different histopathological grades of pancreatic ductal adenocarcinoma (PDAC).

Methods: From July 2012 to August 2017, this retrospective study comprised 56 patients with confirmed histopathological PDAC (32 men, 24 women, mean age 64.04±7.

Computational insights into the binding pattern of mitochondrial calcium uniporter inhibitor through homology modeling, molecular dynamics simulation, binding free energy prediction and density functional theory calculation.

The mitochondrial calcium uniporter (MCU) is the critical protein of the inner mitochondrial membrane that is the primary mediator for calcium uptake into the mitochondrial matrix. Herein we built the optimal homology model of human MCU which was refined through all-atom molecular dynamics simulation. Then, the binding mode of known inhibitor was predicted through molecular docking method, along with molecular dynamics simulation and binding free energy calculation to verify the docking result and stability of the protein-inhibitor complex.

Comparison between magnetic resonance hysterosalpingography and conventional hysterosalpingography: direct visualization of the fallopian tubes using a novel MRI contrast agent mixture.

Background: Magnetic resonance hysterosalpingography (MR-HSG) is a promising technique in the work-up of female infertility. Few existing MR-HSG studies focus on the comparison between MR-HSG with gold standard examination.

Purpose: To compare the diagnostic value of MR-HSG with conventional HSG in patients receiving both exams in one day.

Complete chloroplast genome sequence of (Juglandaceae), an endangered perennial plant.

(Juglandaceae) is a tertiary relict tree restricted to southeastern China and northern Vietnam. Here, we first report and characterize its complete chloroplast genome based on Illumina paired-end sequencing data. The complete plastid genome was 160,065 bp, which contained inverted repeats (IR) of 25,786 bp separated by a large single-copy (LSC) and a small single copy (SSC) of 89,759 bp and 18,734 bp, respectively.

Detoxification of DON by photocatalytic degradation and quality evaluation of wheat.

Deoxynivalenol (DON) is regarded as the most common contaminant of cereal grains. Therefore, finding an efficient and safe detoxification technology is of great significance in the field of food. In this study, upconversion nanoparticles@TiO composites were used for the photocatalytic degradation of DON in wheat.

Predicting necrosis in adnexal torsion in women of reproductive age using magnetic resonance imaging.

Purpose: To identify the diagnostic performance of magnetic resonance (MR) imaging for patients with adnexal torsion and to develop a predictive model for necrosis related to torsion.

Methods: The institutional ethics committee approved this retrospective study. A total of 56 women with a preoperative pelvic MR scan and a surgical and pathologic diagnosis of adnexal torsion were enrolled from five institutions.

Experimental Research and Analysis on Fatigue Life of Carbon Fiber Reinforced Polymer (CFRP) Tendons.

The fatigue life of carbon fiber reinforced polymer (CFRP) tendons was studied in this paper. A new wedge-type anchorage system was applied to the fatigue test of CFRP tendons and demonstrated an excellent fatigue resistance. In the test and analytical data, the fatigue stress ranged from 200 MPa to 800 MPa, and maximum stresses from 0.

Community-associated PVL ST22 predominates in skin and soft tissue infections in Beijing, China.

Purpose: Community-associated (CA ) is the most common causative pathogen of the skin and soft tissue infections (SSTIs). This study aims to determine clonal distribution, virulence factors of CA clinical isolates from purulent SSTIs in Beijing, China.

Materials And Methods: CA- isolates were collected from 115 outpatients with purulent SSTIs from the department of dermatology from April 2015 to April 2017.

Complete chloroplast genome sequence of (hamamelidaceae), a rare and endangered species endemic to China.

(Hamamelidaceae) is a rare and endangered species endemic to China. Here, we first report and characterize the complete chloroplast genome sequence of based on Illumina paired-end sequencing data. The complete plastid genome was 160,406 bp in length, which contained two inverted repeats (IRs) of 26,282 bp separated by a large single-copy (LSC) and a small single copy (SSC) of 88,920 bp and 18,922 bp, respectively.

Assessing the toxicity in vitro of degradation products from deoxynivalenol photocatalytic degradation by using upconversion nanoparticles@TiO composite.

Deoxynivalenol (DON) is one of the most globally prevalent mycotoxins mainly produced by Fusarium species. It can cause pollution to water environmental quality due to its water solubility. Therefore, it is necessary to develop a green and efficient detoxification technology for DON.

IL1A & IL1B genetic polymorphisms are risk factors for thyroid cancer in a Chinese Han population.

Introduction: Thyroid carcinoma accounts for a large proportion of endocrine neoplasia, and the relationship between inflammation and thyroid cancer has been previously validated. IL-1α (Interleukin 1 alpha) and IL-1β (Interleukin 1 beta), encoded by IL1A and IL1B, respectively, are implicated in numerous inflammatory responses and in tumor progression. The objective of this research was to assess the association of genetic polymorphisms of IL1A and IL1B with the risk of thyroid cancer in a Chinese Han population.