Publications by authors named "Du-Jiang Fu"
Basement membrane plays an important role in tumor invasion and metastasis, which is closely related to prognosis. However, the prognostic value and biology of basement membrane genes (BMGs) in prostate cancer (PCa) remain unknown. In the TCGA training set, we used differentially expressed gene analysis, protein-protein interaction networks, univariate and multivariate Cox regression, and least absolute shrinkage and selection operator regression to construct a basement membrane-related risk model (BMRM) and validated its effectiveness in the MSKCC validation set.
View Article and Find Full Text PDFThe suppressor of variegation enhancer of zeste-trithorax (SET) domain methyltransferases have been reported to function as key regulators in multiple tumor types by catalyzing histone lysine methylation. Nevertheless, our understanding on the role of these lysine methyltransferases, including SETD4, in prostate cancer (PCa) remains limited. Hence, the specific role of SETD4 in PCa was investigated in this study.
View Article and Find Full Text PDFArticle Synopsis
- CircSMARCC1, a type of circular RNA, is found to be significantly increased in prostate cancer (PCa) cells and tissues, playing a critical role in tumor growth and spread.* -
- The study demonstrated that circSMARCC1 enhances the expression of CCL20 by inhibiting miR-1322, activating the PI3K-Akt signaling pathway, and facilitating M2 polarization of tumor-associated macrophages (TAMs), which contributes to PCa progression.* -
- High levels of circSMARCC1 correlate with increased infiltration of specific TAMs in the tumor microenvironment, suggesting it promotes tumor progression through interactions between cancer cells and macrophages.*
Background: More and more studies have shown that circular RNAs (circRNAs) play a critical regulatory role in many cancers. However, the potential molecular mechanism of circRNAs in prostate cancer (PCa) remains largely unknown.
Methods: Differentially expressed circRNAs were identified by RNA sequencing.