Pharmacokinetic Interactions Between Tegoprazan and the Combination of Clarithromycin, Amoxicillin and Bismuth in Healthy Chinese Subjects: An Open-Label, Single-Center, Multiple-Dosage, Self-Controlled, Phase I Trial.

Background: Tegoprazan is a potassium-competitive acid blocker that inhibits gastric acid and which may be used for eradicating Helicobacter pylori. This study focuses on the pharmacokinetic interaction and safety between tegoprazan and the combination of clarithromycin, amoxicillin and bismuth in healthy Chinese subjects.

Methods: An open-label, three-period, single-center, multiple-dosage, single-sequence, phase I trial was conducted in 22 healthy subjects.

Synergistic effects and molecular mechanisms of DL-3-n-butylphthalide combined with dual antiplatelet therapy in acute ischemic stroke.

DL-3-n-butylphthalide (NBP) is isolated from the seeds of Apium graveolens L., and has been recently used as a neuroprotective agent for acute ischemic stroke. The present study aimed to determine the efficacy and safety of the combined use of dual antiplatelet therapy (DAPT) and NBP for treating of acute ischemic stroke in rats and to explore the synergistic mechanism of this treatment strategy in rat middle cerebral artery occlusion models.

Solar-Powered Switch of Antiferromagnetism/Ferromagnetism in Flexible Spintronics.

The flexible electronics have application prospects in many fields, including as wearable devices and in structural detection. Spintronics possess the merits of a fast response and high integration density, opening up possibilities for various applications. However, the integration of miniaturization on flexible substrates is impeded inevitably due to the high Joule heat from high current density (10 A/m).

Comparison between an SGLT2 inhibitor and insulin in tumor-to-tissue contrasts in F-FDG PET imaging of diabetic mice.

F-fluorodeoxyglucose positron emission tomography (F-FDG PET) has been widely utilized for tumor diagnosis. Hyperglycemia affects the F-FDG uptake and reduces tumor-to-tissue contrasts, however, ideal hypoglycemic drugs are lacking. This study compared the role of insulin with the novel widely used hypoglycemic drug, sodium-glucose cotransporter 2 (SGLT2) inhibitor, on F-FDG PET imaging in diabetic conditions.

Deterministic Magnetization Reversal in Synthetic Antiferromagnets using Natural Light.

Traditional current-driven spintronics is limited by localized heating issues and large energy consumption, restricting their data storage density and operation speed. Meanwhile, voltage-driven spintronics with much lower energy dissipation also suffers from charge-induced interfacial corrosion. Thereby finding a novel way of tuning ferromagnetism is crucial for spintronics with energy-saving and good reliability.

Manipulations of Spin Waves by Photoelectrons in Ferromagnetic/Non-Ferromagnetic Alloyed Film.

Spin waves are considered to be an alternative carrier with great promise for information sensing. The feasible excitation and low-power manipulation of spin waves still remain a challenge. In this regard, natural light enablings spin-wave tunability in Co Al -alloyed film is investigated.

Ultrasmall iron-gallic acid coordination polymer nanodots with antioxidative neuroprotection for PET/MR imaging-guided ischemia stroke therapy.

Oxidative stress from reactive oxygen species (ROS) is a reperfusion injury factor that can lead to cell damage and death. Here, ultrasmall iron-gallic acid coordination polymer nanodots (Fe-GA CPNs) were developed as antioxidative neuroprotectors for ischemia stroke therapy guided by PET/MR imaging. As proven by the electron spin resonance spectrum, the ultrasmall Fe-GA CPNs with ultrasmall size, scavenged ROS efficiently.

A pharmacokinetics interaction study of antiplatelet agents aspirin and clopidogrel combined with dl-3-n-butylphthalide in rats by liquid chromatography-tandem mass spectrometry.

A sensitive and specific high-performance liquid chromatography-tandem mass spectrometry method has been developed to determine the pharmacokinetic interactions of the antiplatelet agents aspirin and clopidogrel combined with dl-3-n-butylphthalide. For the determination of aspirin metabolite salicylic acid, clopidogrel inactive metabolite SR26334 and NBP prototype drug in rat plasma, plasma samples were prepared by precipitation of proteins using methanol containing 0.1% formic acid, followed by centrifugation.

Deterministic Magnetic Switching in Perpendicular Magnetic Trilayers Through Sunlight-Induced Photoelectron Injection.

Finding an energy-efficient way of switching magnetization is crucial in spintronic devices, such as memories. Usually, spins are manipulated by spin-polarized currents or voltages in various ferromagnetic heterostructures; however, their energy consumption is relatively large. Here, a sunlight control of perpendicular magnetic anisotropy (PMA) in Pt (0.

Radioiodination, purification, and evaluation of antihuman tumor-derived immunoglobulin G light chain monoclonal antibody in tumor-bearing nude mice.

We report the synthesis and biological evaluation of I-labeled antihuman tumor-derived immunoglobulin G (IgG) light chain monoclonal antibody (4E9) ([ I]I-4E9) as a promising probe for tumor imaging. [ I]I-4E9 was synthesized in radiochemical yield of 89.9 ± 4.

Evaluation of cytotoxicity and biodistribution of mesoporous carbon nanotubes (pristine/-OH/-COOH) to HepG2 cells and healthy mice .

Mesoporous carbon nanotubes (mCNTs) hold great promise interests, owing to their superior nano-platform properties for biomedicine. To fully utilize this potential, the toxicity and biodistribution of pristine and surface-modified mCNTs (-OH/-COOH) should preferentially be addressed. The results of cell viability suggested that pristine mCNTs induced cell death in a concentration-dependent manner.

Surface-active compounds induce time-dependent and non-monotonic fluid-fluid displacement during low-salinity water flooding.

Hypothesis: In a porous medium saturated with oil (containing oleic surfactant) and saline water, salinity reduction alters the thermodynamic equilibrium and induces spatial redistribution of surfactants, changing the local fluid configuration. During fluid-fluid displacement, this local change reshapes global fluid flows, and thus results in improved oil displacement.

Experiments: We performed microfluidic experiments in a centimeter-long pore-network model with a fracture and a dead-end model to observe both the macroscale flows and microscopic fluid configuration evolution.

Influence of Different Bifurcation Angles on the Flame Propagation of Gas Explosions in Three-Way Bifurcated Pipes.

Exploring the flame propagation law in the process of gas explosion under different bifurcation angles is of great significance to the design of coal mine roadway and the prevention of gas explosion accidents. To study the variation of flame propagation law with bifurcation angle, an in-house experimental system based on a small scale three-way bifurcated pipe was developed to perform gas explosion experiments using mixtures of premixed methane-air with a methane concentration of 9.5%.

Noninvasive Evaluation of Multidrug Resistance via Imaging of ABCG2/BCRP Multidrug Transporter in Lung Cancer Xenograft Models.

Chemotherapy is an important method for the treatment of lung cancer, but multidrug resistance (MDR) greatly reduces the efficacy. The superfamily of ATP-binding cassette (ABC) transport proteins is related to MDR. As a subfamily of ABC proteins, ABCG2/BCRP (breast cancer resistance protein, BCRP) is considered a major player in the development of cancer MDR.

Atypical Hemolytic Uremic Syndrome-Associated FHR1 Isoform FHR1*B Enhances Complement Activation and Inflammation.

Atypical hemolytic uremic syndrome (aHUS) is a rare but severe type of thrombotic microangiopathy that is triggered by the abnormal activation of the alternative complement pathway. Previous studies have reported that three completely linked coding variants of form two haplotypes, namely, *A (c.469C, c.

Tc-labeled peptide targeting interleukin 13 receptor α 2 for tumor imaging in a cervical cancer mouse model.

Objective: Pep-1 (CGEMGWVRC) can potently bind to interleukin 13 receptor α 2 (IL-13Rα2), a tumor-restricted receptor found to be expressed in various malignancies. In this study, we intended to prepare a Tc-labeled probe and evaluate its in vivo tumor accumulation properties in a cervical cancer xenograft model.

Methods: The Pep-1 was designed and radiolabeled with Tc by conjugation with mercaptoacetyl-triglycine (MAG).

Arginine-Arginine-Leucine Peptide Targeting Heat Shock Protein 70 for Cancer Imaging.

Arg-Arg-Leu (RRL) is a potent tumor-homing tripeptide. However, the binding target is unclear. In this study, we intended to identify the binding target of RRL and evaluate the tumor targeting of Tc-MAG-RRL .

Sulfur-Induced Growth of Coordination Polymer Derived-Straight Carbon Nanotubes on Carbon Nanofiber Network for Zn-Air Batteries.

Low-cost heteroatom-doped carbon nanomaterials have been widely studied for efficient oxygen reduction reaction and energy storage and conversion in metal-air batteries. A Masson pine twigs-like 3-dimensional network construction of carbon nanofibers (CNFs) with abundant straight long Co, N, and S-doped carbon nanotubes (CNTs) is developed by thermal treatment of Co-based polymer coated onto polyacrylonitrile nanofiber network together with thiourea at 900 °C, denoted as CNFT-Co S -900. It is interesting to note that the introduction of a high concentration of sulfur does not lead to the complete toxicity of catalysts, but promotes the axial growth to selectively form straight CNTs instead of curly bamboo-like CNTs.

Tri-Manganese(III) Salen-Based Cryptands: A Metal Cooperative Antioxidant Strategy that Overcomes Ischemic Stroke Damage .

Oxidative stress is one of the hallmarks of ischemic stroke. Catalase-based (CAT) biomimetic complexes are emerging as promising therapeutic candidates that are expected to act as neuroprotectants for ischemic stroke by decreasing the damaging effects from HO. Unfortunately, these molecules result in the unwanted production of the harmful hydroxyl radical, HO.