Three novel sesquiterpene polyol esters from the root bark of Maxim and their nitric oxide inhibitory activity.

Three new sesquiterpene polyol ester compounds angulatin V [1,15-diacetoxy-2-(α-methyl)-butanoyloxy-4α,6α-dihydroxy-8α-isobutanoyloxy-9-benzoxy--dihydroagarofuran], angulatin W [1,2-diacetoxy-4α,6α-dihydroxy-8-carbonyl-9-benzoxy-15-isobutanoyloxy--dihydroagarofuran], angulatin X [1,28α-triacetoxy-4α, 6α-dihydroxy-9-benzoxy-15-nicotinyl--dihydroagarofuran] (), together with one known compound Putterine B (), were isolated from the root bark of Maxim. The structures of compounds were elucidated by NMR, HRESIMS, IR data, and comparison with the literature data. The anti-inflammatory activity of all compounds was evaluated by measuring nitric oxide production in RAW264.

Analgesic efficacy of adding the IPACK block to multimodal analgesia protocol for primary total knee arthroplasty: a meta-analysis of randomized controlled trials.

Background: Total knee arthroplasty (TKA) is a standard treatment for end-stage degenerative knee disease. Most patients will experience moderate-to-severe postoperative knee pain, significantly affecting rehabilitation. However, controversy remains regarding the efficacy of adding the interspace between the popliteal artery and capsule of the knee (IPACK) into multimodal analgesia protocol.

Near-Infrared Light-Controllable Multifunction Mesoporous Polydopamine Nanocomposites for Promoting Infected Wound Healing.

The successful treatment of infected wounds requires strategies with effective antimicrobial, anti-inflammatory, and healing-promoting properties. Accordingly, the use of Cu and tetracycline (TC), which can promote angiogenesis, re-epithelialization, and collagen deposition, also antibacterial activity, at the wound site, has shown application prospects in promoting infected wound repair. However, realizing controllable release to prolong action time and avoid potential toxicities is critical.

Study on the mental health status of anesthesiologists and its influencing factors.

Objective: This study is on mental health status of anesthesiologists and its influencing factors.

Methods: Electronic questionnaires were given out to anesthesiologists through online platforms such as WeChat for information sharing among anesthesiologists. The included anesthesiologists were encouraged to distribute this platform to other anesthesiologists.