The impact of non-pharmacological interventions on nasopharyngeal , , , carriage and the change of pneumococcal vaccination in healthy children under 5 years old in Beijing, China.

Background: We analyzed the impact of non-pharmacological interventions (NPIs) andPCV13 inoculation on nasopharyngeal (NP) carriage of (Sa), (Sp), (Mc)and (Hi) in healthy children under 5 years old inBeijing, China.

Research Design And Methods: NP swabs were taken from healthy childrenseeking routine well-child care at the pediatricpreventive health clinic. NP swabs were frozenin Tryptic Soy Broth (TSB) medium and stored at -80°C, and bacterial was detectedby culture.

Sharp Rise in High-Virulence Bordetella pertussis with Macrolides Resistance in Northern China.

Objective: To elucidate the evolution of antigen genotype and antimicrobial resistance distribution of () from 2019 to 2023 in northern China.

Methods: Polymerase chain reaction (PCR) amplification and sequencing were utilized to identify the seven antigen genotypes (). E-test and Kirby-Bauer (K-B) disc diffusion were employed to determine the minimum inhibitory concentration (MIC) and zone of inhibition for against antimicrobial agents.

Incidence of Pertussis in Older Children Underestimated in the Whole-Cell Vaccine Era: A Cross-Sectional Seroprevalence Study.

Objectives: China was once a country with a high incidence of pertussis, with reported incidence rates exceeding 100 per 100,000 before the introduction of the pertussis vaccine. After the widespread implementation of the pertussis vaccination program, reported cases of pertussis significantly decreased. This study aimed to investigate the serological prevalence of pertussis among school-age children during the administration of the whole-cell pertussis (wP) vaccine in China.

Survival machine learning model of T1 colorectal postoperative recurrence after endoscopic resection and surgical operation: a retrospective cohort study.

Objective: To construct a postoperative recurrence prediction model for patients with T1 colorectal cancer after endoscopic resection and surgical operation via survival machine learning algorithms.

Methods: Based on two tertiary-level affiliated hospitals, case data of 580 patients with T1 colorectal cancer treated by endoscopic resection and surgery were obtained, and patients' personal information, treatment modalities, and pathology-related information were extracted. After Boruta's algorithmic feature selection, predictors with significant contributions were identified.

Psychosocial adjustment and influencing factors in patients with newly diagnosed colorectal cancer: A latent profile analysis.

Purpose: To identify subgroups of psychosocial adjustment among patients with newly diagnosed colorectal cancer, and to examine the inflencing factors of different subgroups.

Methods: The study surveyed 490 participants in Guangzhou from July 2022 to June 2023 using face-to-face method. The scales measured psychosocial adjustment, resilience, and coping styles.

Illness behavior and its predictors in young and middle-aged colorectal cancer patients: A latent profile analysis.

Purpose: To describe the characteristics of sick role adaptation and understand the differences in young and middle-aged colorectal cancer (CRC) patients.

Methods: 225 colorectal cancer patients aged 18-59 admitting to a specialized oncology hospital in Guangzhou, China were involved from January to April 2022. Socio-demographic characteristics, disease-related characteristics, scores of Illness Behavior Questionnaire, Hospital Anxiety and Depression Scale, the Brief Illness Perception Questionnaire, Mishel Uncertainty in Illness Scale and Medical Coping Modes Questionnaire were applied to collect quantitative data.

Can strengthening digital infrastructure enhance productivity in the cultural industry? evidence from Tibet.

This study, grounded in the Total Factor Productivity (TFP) theoretical framework, examines the impact of digital infrastructure on the productivity of Tibet's cultural industry from 2011 to 2021. It aims to uncover how the innovative allocation of production factors can enhance new-quality productivity. The core aspect of new-quality productivity is the improvement of TFP, with digital infrastructure promoting the cultural industry's development by optimizing industrial agglomeration, improving logistics efficiency, and reducing the urban-rural consumption gap.

Depressive intensity, duration, and their associations with cognitive decline: a population-based study in Korea.

Existing epidemiological studies have ignored the effect of depressive duration on cognitive decline despite the presence of biological cues and understudied the depression-cognition association in Asian countries in the context of increasing cognitive burden worldwide. We aimed to comprehensively characterize the effects of depressive duration and intensity on cognitive decline at the population level. A total of 6406 individuals from the Korean Longitudinal Study of Aging (KLoSA) from 2010 to 2018 were included to generate four datasets with durations of 2, 4, 6, and 8 years.

Identification and quantitative trait locus mapping of Tartary buckwheat pre-harvest sprouting.

Background: Tartary buckwheat (Fagopyrum tartaricum) is particularly vulnerable to pre-harvest sprouting (PHS) due to its extended flowering and fruiting cycle, especially during periods of prolonged rainfall. This susceptibility has significant adverse effects on yield, quality and post-harvest processing. In this study, a recombinant inbred lines (RILs) population (XJ-RILs) was developed from a cross between the PHS-susceptible Tartary buckwheat variety 'Xiaomiqiao' (female parent) and the highly PHS-resistant variety 'Jinqiaomai 2' (male parent).

Association Between Multimorbidity and Depression in Older Adults: Evidence From Six Large Longitudinal Cohorts.

Background: Multimorbidity may increase the risk of depression in older adults, but the global average effect of multimorbidity on depression remains unknown. This research aimed to exclude the regional heterogeneity to quantify the exposure-response association between multimorbidity and depression in older adults worldwide.

Method: We collected 23,947 participants aged 65 years or above from six large prospective cohorts from developed and developing countries, including Mexico, South Korea, Europe, America, China, and England.

Association between cognitive decline and depression in middle-aged and older adults: Findings from six large cohorts in different countries.

Background: The relationship between depression and cognition in middle-aged adults is a topic of interest. Whether poor cognitive function exacerbates depression remains controversial. We clarified the association between cognitive decline and depression based on six nationwide cohorts.

Longitudinal Trajectories of Psychological Distress and Its Influence Factors in Young and Middle-Aged Patients With Colorectal Cancer.

Aims: To identify the longitudinal trajectories of psychological distress and to explore the predictive factors of different trajectories among young and middle-aged colorectal cancer patients from diagnosis to 6 months postoperation.

Design: A longitudinal study was conducted, guided by the STROBE checklist.

Methods: A total of 214 patients were recruited from July 2021 to May 2022 at a cancer hospital in Guangzhou, China.

Leveraging AI technology for distinguishing Eucommiae Cortex processing levels and evaluating anti-fatigue potential.

Eucommiae Cortex (ECO) is a traditional medicinal and edible plant endemic to China, highly prized for its numerous health benefits. It typically undergoes special processing before application. The efficacy of ECO is influenced by processing techniques, necessitating the assurance of stability and consistency in its effects.

Phenotypic diversity of Bordetella pertussis against Trimethoprim/Sulphamethoxazole in vitro tests.

Background: Trimethoprim/sulfamethoxazole (TMP/SMZ), traditionally a second-line drug, is now proposed as the primary alternative treatment for macrolide-resistant Bordetella pertussis (B.pertussis). Thus, there is an urgent need to evaluate the phenotypic profile of B.

A nomogram model for predicting frailty in middle-aged and elderly patients with colorectal cancer:A cross-sectional study.

Purpose: Frailty is a syndrome caused by multiple factors and can lead to serious consequences for middle-aged and elderly patients with colorectal cancer. However, few studies have comprehensively explored predictors of frailty and built predictive models. Therefore, our aim is to develop and evaluate a predictive model for frailty in middle-aged and elderly patients with colorectal cancer.

Nasopharyngeal carriage of among children aged 30 days to <60 months in Beijing and Shenzhen, China (2018-2021) during pneumococcal conjugate vaccine introduction and the coronavirus disease (COVID-19) pandemic.

Objectives: To describe the carriage rate, serotype distribution, and antimicrobial susceptibility patterns of () nasopharyngeal (NP) isolates among healthy children aged 30 days to <60 months in the cities of Beijing and Shenzhen during 2018-2021.

Methods: A NP swab sample was collected among four annual cohorts of healthy children at routine well-child visits. was identified by culture, optochin sensitivity and bile solubility, serotypes determined by latex agglutination and Quellung, and antimicrobial susceptibility testing performed using E-test strips.

Zosuquidar Promotes Antitumor Immunity by Inducing Autophagic Degradation of PD-L1.

The intracellular distribution and transportation process are essential for maintaining PD-L1 (programmed death-ligand 1) expression, and intervening in this cellular process may provide promising therapeutic strategies. Here, through a cell-based high content screening, it is found that the ABCB1 (ATP binding cassette subfamily B member 1) modulator zosuquidar dramatically suppresses PD-L1 expression by triggering its autophagic degradation. Mechanistically, ABCB1 interacts with PD-L1 and impairs COP II-mediated PD-L1 transport from ER (endoplasmic reticulum) to Golgi apparatus.

Seroprevalence of B. pertussis infection and the changes of specific antibody levels in health care workers during the first two years of COVID-19 in Wuhu, China.

Background: The reported number of pertussis cases declined after the implementation of COVID-19 prevention and control measures, however, the burden of pertussis among adults in China remains largely unknown. Additionally, the waning of natural antibody level has also rarely been assessed.

Methods: A total of 762 healthcare workers (HCWs) who had underwent the health examinations in 2021 and 2022 were included.

Association between depressive duration and cognitive decline in middle-aged and older adults: Evidence from the Health and Retirement Study 2010-2018.

Background: Depression has been found to be associated with cognitive decline, but whether longer depressive durations lead to more severe cognitive declines has not been investigated. We aimed to estimate the association between depressive duration and cognitive decline in middle-aged and older Americans based on a large-scale representative population study.

Methods: We included 27,886 participants from the Health and Retirement Study (HRS) in 2010-2018.

Structural analysis and bioavailability study of low-molecular-weight chondroitin sulfate‑iron complexes prepared by photocatalysis-Fenton reaction.

Increasing studies focus on depolymerization of chondroitin sulfate (CS) to enhance its biological activities. In the present study, low-molecular-weight chondroitin sulfate (LMWCS)‑iron complexes were obtained by photocatalysis-Fenton reaction. After degradation with the optimal condition of 0.