Percutaneous transforaminal endoscopic decompression versus posterior short-segment fusion for treating degenerative lumbar scoliosis with lumbar spinal stenosis: a cohort study with a minimum five year followup.

Purpose: This retrospective cohort study aimed to compare the clinical outcomes of percutaneous transforaminal endoscopic decompression (PTED) with those of posterior lumbar interbody fusion (PLIF) for the treatment of degenerative lumbar scoliosis (DLS) with lumbar spinal stenosis (LSS).

Methods: In this study, 143 DLS patients who met the inclusion criteria from January 2016 to March 2019 were retrospectively analyzed and divided into the PTED and PLIF groups. The propensity score matching (PSM) method was used to adjust for imbalanced confounding variables between the groups.

Variations in Regional Characteristics of Interstitial Cells of Cajal in the Murine Stomach.

Rhythmic bioelectrical activity known as slow waves is in part responsible for coordinating the contractions in the stomach, which play a crucial role in maintaining healthy digestion. Slow waves are generated by specialized pacemaker cells named interstitial cells of Cajal (ICC) distributed within smooth muscle cells of the stomach wall. In this study, tissue samples were collected from four regions (cardia, fundus, corpus, and antrum) of the stomach of a transgenic mouse that expressed green fluorescent protein in the ICC.

Three-dimensional Quantitative Evaluation of Interfacial Mass Transfer for Performance Enhanced and Durable Large-scale Reversible Protonic Ceramic Cells.

Reversible protonic ceramic cells (R-PCCs) hold significant promise for energy storage and conversion. However, achieving high-performance, large-scale cells remains challenging, primarily due to issues with compatibility and adhesion at the electrode-electrolyte interface. Here, a scalable strategy is presented for regulating an active interface structure (AIS) via tape casting to develop high-performance, durable R-PCCs.

A novel stemness-related lncRNA signature predicts prognosis, immune infiltration and drug sensitivity of clear cell renal cell carcinoma.

Background: Clear cell renal cell carcinoma (ccRCC) is a prevalent urogenital malignancy characterized by heterogeneous patterns. Stemness is a pivotal factor in tumor progression, recurrence, and metastasis. Nevertheless, the impact of stemness-related long non-coding RNAs (SRlncRNAs) on the prognosis of ccRCC remains elusive.

SIRT7 expression predicts poor prognosis in upper tract urothelial carcinoma undergoing postoperative platinum-based adjuvant chemotherapy.

Introduction To evaluates the expression of SIRT7 in UTUC as well as the predictive value for prognosis in patients undergoing radical nephroureterectomy followed platinum-based adjuvant chemotherapy. Methods Pathological samples of 146 UTUC with clinical stage T2 and above undergoing radical nephrectomy (RNU) were collected. All patients received adjuvant cisplatin-based chemotherapy and 40 UTUC patients received second-line immunotherapy after disease progression.

Integrated bioinformatics investigation and experimental validation reveals the clinical and biological significance of chromobox family in breast cancer.

Chromobox (CBX) proteins are essential components of the Polycomb group and play pivotal roles in tumor onset, progression, and metastasis. However, the prognostic significance and functions of CBXs in the advancement of breast cancer (BC) have not been sufficiently investigated. A comprehensive analysis of the expression and prognostic relevance of CBX1-8 in BC was conducted comprehensively using The Cancer Genome Atlas (TCGA) and multiple databases.

Electromechanical coupling across the gastroduodenal junction.

The gastroduodenal junction is uniquely capable of regulating digestive functions in the gastrointestinal system. The pyloric sphincter, which demarcates the stomach from the small intestine, acts as a mechanical and electrical barrier, isolating each organ, thus enabling independent behaviors that are critical for proper digestion. Unique electrical patterns in the stomach, pylorus, and duodenum underpin the distinct contractile patterns of these regions, and improper organization of these mechanical behaviors leads to clinical conditions such as gastroparesis and dumping syndrome.

The Impact of Alpha-Neurofeedback Training on Gastric Slow Wave Activity and Heart Rate Variability in Humans.

Introduction: Neuromodulation of cortical brain regions associated with the gut-brain axis may have the potential to modulate gastric function. Previous studies have shown phase-amplitude coupling between the electroencephalogram (EEG) alpha band frequency of the insula (Ins) and gastric slow wave (GSW) activity. This study investigated the first evidence of alpha band EEG-neurofeedback (EEG-NF) training to explore its effects on GSW activity and heart rate variability (HRV).

Gut-disc axis: A Mendelian randomization study on the relationship between gut microbiota and cervical spondylosis.

The gut-disc axis, which refers to the interaction between gut microbiota and bone health, has recently garnered widespread attention in the scientific community. However, it remains to be determined whether gut microbiota directly induces cervical spondylosis (CS). This study employed a bidirectional 2-sample Mendelian randomization (MR) analysis to explore the potential causal link between gut microbiota and CS.

Perioperative enhanced recovery program implementation improves clinical outcomes in patients with ulcerative colitis after total proctocolectomy with ileal pouch-anal anastomosis.

Background: Total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is widely regarded as a definitive surgical option for managing ulcerative colitis (UC). Enhanced recovery programs (ERP) have shown potential in better outcomes following surgery; however, their perioperative benefits in UC patients undergoing IPAA remain insufficiently investigated.

Methods: This study included UC patients who underwent IPAA between January 2008 and September 2023 across multiple affiliated centers within the China UC Pouch Center Union.

Comparison of Learning Curves and Clinical Outcomes in Unilateral Biportal Endoscopic Spinal Surgery Versus Percutaneous Transforaminal Endoscopic Surgery: A Cumulative Sum Analysis.

Purpose: Endoscopic spine surgery has been widely performed to treat degenerative spinal diseases to mitigate the risks and complications associated with traditional open surgery. However, endoscopic procedures pose challenges, including a limited field of view and a restricted operating space, which can affect the surgeon's learning curve. This study aimed to evaluate the learning curves for unilateral biportal endoscopic spinal surgery (UBESS) and percutaneous transforaminal endoscopic surgery (PTES) by performing cumulative sum (CUSUM) analysis and to assess their efficacies in managing degenerative spinal diseases.

Effects of ultrasonic rotating extrusion assisted wire arc additive manufacturing on the microstructure and mechanical properties of 5356 aluminum alloy.

Wire Arc Additive Manufacturing (WAAM) for the fabrication of lightweight Al alloy represents a burgeoning area of research. Despite this, the presence of porosity defects, coarse surface grain sizes, and the clustering of precipitated phases in WAAM-produced Al alloy samples have been identified as detrimental to their mechanical properties, rendering them inadequate for contemporary service requirements. In this investigation, an innovative approach termed Ultrasonic-Rotating Extrusion-Wire Arc Additive Manufacturing (U-RE-WAAM) was proposed, which integrates the synergistic effects of ultrasonic and mechanical force fields into the WAAM process.

Automated diagnosis and grading of lumbar intervertebral disc degeneration based on a modified YOLO framework.

Background: The high prevalence of low back pain has led to an increasing demand for the analysis of lumbar magnetic resonance (MR) images. This study aimed to develop and evaluate a deep-learning-assisted automated system for diagnosing and grading lumbar intervertebral disc degeneration based on lumbar T2-weighted sagittal and axial MR images.

Methods: This study included a total of 472 patients who underwent lumbar MR scans between January 2021 and November 2023, with 420 in the internal dataset and 52 in the external dataset.

Designing Polychromatic Luminescence in Mn-Doped CsNaLuCl Double Perovskite Crystals via Energy Transfer Engineering for Optical Thermometry and X-ray Imaging.

Metal halide double perovskites with splendid optical features have been considerably investigated for optoelectronic applications. Herein, a series of Mn-doped CsNaLuCl double perovskite crystals were prepared. Via adopting the density functional theory calculation, the effect of Mn doping on the electronic structure of the CsNaLuCl compound was discussed.

Redox-Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3-Mediated NRF2 Deubiquitination.

Inflammatory bowel disease (IBD) is associated with oxidative stress and redox signaling disruption. It is recently reported that proautophagic autophagy/beclin-1 regulator 1 (AMBRA1) is a positive modulator of the NF-κB pathway that promotes intestinal inflammation. However, its effect on intestinal redox state and whether AMBRA1 is regulated by oxidative stress remain unknown.

Complete Breakup of Liquids into Ultrafine Droplets by Grid Turbulence.

Ultrafine droplets are crucial in materials processing and nanotechnology, with applications in nanoparticle preparation, water evaporation, nanodrug delivery, nanocoating, among numerous others. While the potential of turbulent gas flow to enhance liquid breakup is acknowledged, constructing turbulence-driven atomizers for ultrafine droplets remains challenging. Herein, we report the innovation of grid-turbulence atomization (GTA), which employs a rotating mesh to deliver liquid and an air knife to spray ultrafine droplets.

Clinical and radiological outcomes of lumbar endoscopic decompression for treating lumbar spinal stenosis and degenerative lumbar scoliosis: a retrospective study at mean 4.4 years follow-up.

Purpose: To assess the clinical and radiological outcomes of lumbar endoscopic decompression for the treatment of lumbar spinal stenosis (LSS) with concurrent degenerative lumbar scoliosis (DLS).

Methods: This study retrospectively reviewed 97 patients with LSS and DLS who underwent lumbar endoscopic decompression between 2016 and 2021. The average follow-up duration was 52.

Exposure to smoking and greenspace are associated with allergy medicine use - A study of wastewaterin 28 cities of China.

Allergies have become an important public health issue as their occurrence is reportedly on the rise around the world. Exposure to environmental factors is considered as trigger for allergic diseases. However, there was limited data on the importance of each factor, particularly in China.

Mouse totipotent blastomere-like cells model embryogenesis from zygotic genome activation to post implantation.

Embryo development begins with zygotic genome activation (ZGA), eventually generating blastocysts for implantation. However, in vitro systems modeling the pre-implantation development are still absent and challenging. Here, we used mouse totipotent blastomere-like cells (TBLCs) to develop spontaneous differentiation and blastoid formation systems, respectively.

Roll-to-Roll Flash Joule Heating to Stabilize Electrocatalysts onto Meter-Scale Ni Foam for Advanced Water Splitting.

The seamless integration of electrocatalysts onto the electrode is crucial for enhancing water electrolyzers, yet it is especially challenging when scaled up to large manufacturing. Despite thorough investigation, there are few reports that tackle this integration through roll-to-roll (R2R) methodology, a technique crucial for fulfilling industrial-scale demands. Here, we develop an R2R flash Joule heating (R2R-FJH) system to process catalytic electrodes with superior performance.

A Standardized Classification Scheme for Gastroduodenal Disorder Evaluation Using the Gastric Alimetry System: Prospective Cohort Study.

Background And Aims: Gastric Alimetry™ (Alimetry, New Zealand) is a new clinical test for gastroduodenal disorders involving simultaneous body surface gastric electrical mapping and validated symptom profiling. Studies have demonstrated a range of distinct pathophysiological profiles, and a classification scheme is now required. We used Gastric Alimetry spectral and symptom profiles to develop a mechanism-based test classification scheme, then assessed correlations with symptom severity, psychometrics, and quality of life.

A Pyrrole-Fused Nanographene and its Edge-Perchlorinated Derivative Featuring a Corannulene Core and Five N-doped Heptagons.

A pyrrole-fused analogue of warped nanographene, designated as deca-nitrogen doped 'WNG' (azaWNG), was synthesized through the annular fusion of decapyrroylcorannulene. The resulting azaWNG exhibited extremely limited solubility in common organic solvents and was characterized solely by mass spectrometry. Theoretical calculations revealed that azaWNG has a sunflower-like molecular structure with electron-deficient corannulene as the core and electron-rich pyrrole as the petals, demonstrating a significantly narrower energy gap compared to all-carbon WNG.

A hTfR1 Receptor-Specific VHH Antibody Neutralizes Pseudoviruses Expressing Glycoproteins from Junín and Machupo Viruses.

The Junín virus (JUNV) is one of the New World arenaviruses that cause severe hemorrhagic fever. Human transferrin receptor 1 (hTfR1) has been identified as the main receptor for JUNV for virus entry into host cells. To date, no treatment has been approved for JUNV.

Pan-Cancer Analysis Reveals the Potential of PLOD1 as a Prognostic and Immune Biomarker for Human Cancer.

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1) is known as an enhancer of collagen fiber deposition and cross-linking stability. However, there is limited information on its function in tumors. In this study, we aimed to elucidate the function and potential mechanism of action of PLOD1 across cancers.