Publications by authors named "Du He"

Article Synopsis
  • * The research is a phase II trial involving 37 patients, aiming to assess various outcomes like tumor response rates and survival rates after receiving a specific chemotherapy regimen along with cadonilimab before surgery.
  • * The study has received ethical approval, requires informed consent from participants, and aims to contribute valuable data on the safety and effectiveness of this combined therapy over the course of the trial, which runs until mid-2025.
View Article and Find Full Text PDF
Article Synopsis
  • Advanced pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, and this study tested whether combining the immunotherapy toripalimab with chemotherapy (gemcitabine and nab-paclitaxel) could improve treatment outcomes for patients with advanced PDAC.
  • The results showed median overall survival of 8.9 months and a good safety profile, with no serious side effects reported among the 72 participants.
  • Biomarkers like PD-L1 expression and immune cell interactions were explored, revealing that specific immune cell spatial interactions were significant predictors of treatment response, suggesting potential for tailored therapies in this context.
View Article and Find Full Text PDF
Article Synopsis
  • - The study conducted a systematic review and network meta-analysis to evaluate the effectiveness and acceptability of various brain stimulation techniques (BSTs) like DBS, ECT, rTMS, and tDCS for anxiety disorders, OCD, and PTSD.
  • - Among 1,333 patients analyzed from 41 trials, findings indicated that BSTs such as DBS, ECT, and both high and low-frequency rTMS showed greater efficacy than control treatments, with some techniques also receiving high acceptability ratings.
  • - Limitations include a narrow focus on specific BSTs and the need for further research on a wider range of technologies and parameters for treating diverse psychiatric conditions, with lf-rTMS highlighted as a particularly promising option.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the clinicopathological characteristics and prognosis of combined hepatocellular-cholangiocarcinoma (cHCC-CCA) using data from 72 cases at West China Hospital.
  • Researchers employed techniques like immunohistochemistry and fluorescence in situ hybridization to assess various tumor factors including human epidermal growth factor receptor 2 (HER2) expression and FGFR2 gene alterations.
  • Key findings indicate 49 cases were classic type cHCC-CCA, with an average survival of 18.9 months; tumor size, TNM stage, and serum AFP levels were identified as significant prognostic factors.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the relationship between cartilage endplate (CEP) degeneration and intervertebral disc degeneration from a biomechanical perspective.
  • Four advanced finite element models were developed to assess the impact of CEP degradation through various loading tests.
  • Findings indicate that while daily loading affects disc degeneration significantly, CEP degeneration has a minor effect, highlighting the importance of glycosaminoglycan content and CEP permeability in disc biomechanics.
View Article and Find Full Text PDF

Background: Attentional bias may influence the emotional experiences of breast cancer patients, both positively and negatively. This study aimed to investigate attentional bias in breast cancer patients and its impact on their emotions.

Method: Thirty-eight breast cancer patients completed a modified dot-probe task and the Depression Anxiety and Stress Scale to assess attentional bias and emotional states.

View Article and Find Full Text PDF

There is a significant difference in prognosis and response to chemotherapy between basal and classical subtypes of pancreatic ductal adenocarcinoma (PDAC). Further biomarkers are required to identify subtypes of PDAC. We selected candidate biomarkers via review articles.

View Article and Find Full Text PDF

Background: Psychological distress is highly prevalent and has a severe impact on the quality of life among breast cancer survivors. This type of distress is associated with cognitive failure. However, previous studies have focused solely on the total scale scores of these two concepts while ignoring the unique relationship between specific components.

View Article and Find Full Text PDF

Purpose: To report real-time IRP and FR while performing flexible ureteroscopy in porcine kidney model utilizing LithoVue™ Elite (Boston Scientific®) with different irrigation systems, including automated pumps.

Methods: Using an ex-vivo model of porcine kidney, IRPs were measured with LithoVue Elite. Ureteroscopic settings (US) were tested with all permutations of irrigation methods (IM), working channel occupant (WCO), and ureteral access sheaths (UAS).

View Article and Find Full Text PDF

Introduction: Patients with pancreatic ductal adenocarcinoma (PDAC) remain a poor prognosis despite the development of chemotherapy. Although programmed cell death 1 (PD-1) blockade has shown great efficacy in various solid tumours, its application in treating PDAC is limited. Recent studies have indicated that chemotherapy or stereotactic body radiotherapy (SBRT) may improve the antitumour effect of PD-1 blockade in patients with PDAC.

View Article and Find Full Text PDF
Article Synopsis
  • This study looked at how chromothripsis, a type of DNA damage, could help doctors understand more about pancreatic tumors.
  • They studied 30 patients with high-grade tumors and compared them to 25 with lower-grade tumors.
  • The findings showed that chromothripsis is linked to worse outcomes and can help tell apart aggressive tumors from less serious ones.
View Article and Find Full Text PDF

Background: Elucidating fitness cost associated with field-evolved insect resistance to insecticide is of particular importance to current sustainable pest control. The global pest whitefly Bemisia tabaci has developed resistance to many members of neonicotinoids, but little is known about whitefly resistance to neonicotinoid nitenpyram and its associated fitness cost. Using insecticide bioassay and life-table approach, this study aims to investigate nitenpyram resistance status in field-collected whitefly populations, and to explore whether such resistance is accompanied by a fitness cost.

View Article and Find Full Text PDF

The rise of immunotherapy provided new approaches to cancer treatment. We aimed to describe the contribution of chimeric antigen receptor T cell immunotherapy to future prospects. We analyzed 8035 articles from the Web of Science Core Collection with CiteSpace that covered with various aspects with countries, institutions, authors, co-cited authors, journals, keywords, and references.

View Article and Find Full Text PDF

Background: There are currently three strategies for the duration of LMWH lead-in before DOACs in patients with acute PE: one is at least 5 days, the other is at least 3 days, and the last one is less than 3 days. Which one is the best is yet unknown.

Methods: We divided non-high-risk PE patients into short-LMWH (LMWH <3 days), intermediate-LMWH (LMWH 3-5 days), and long-LMWH (LMWH >5 days) groups, in a 1:1:2 ratio by using propensity score matching.

View Article and Find Full Text PDF

Background: The role of recombinant human granulocyte colony-stimulating factor (rhG-CSF), especially the long-acting factor in the development of cancer-associated venous thromboembolism (VTE) in lung cancer patients who undergo chemotherapy has been understudied, although the use of rhG-CSF has been reported to be associated with an increased risk of VTE.

Methods: We retrospectively reviewed 1,673 lung cancer patients who underwent hospitalized chemotherapy. We performed propensity score matching to offset confounding factors related to cancer-associated VTE development and classified the patients into short-acting (N = 273), long-acting (N = 273), and no rhG-CSF (N = 273) groups.

View Article and Find Full Text PDF

Background: Occurrence of chronic thromboembolic disease (CTED) after 3 or 6 months of standard and effective anticoagulation is not uncommon in patients with acute pulmonary embolism (PE). To date, there has been no scoring model for the prediction of CTED occurrence.

Methods: A Prediction Rule for CTED (PRC) was established in the establishment cohort (n=1,124) and then validated in the validation cohort (n=211).

View Article and Find Full Text PDF

The inverted hyperplastic polyp (IHP) is known as hyperplastic gastric mucosa growth into submucosa and endoscopically presented as sessile or pedunculated submucosa lesion. It occurs in between 3.1% to 20.

View Article and Find Full Text PDF

Objectives: To address the paucity of literature comparing outcomes achieved with utilisation of the high-power holmium:yttrium-aluminium-garnet (Ho:YAG) laser with MOSES technology vs those achieved with the thulium fibre laser (TFL) in mini-percutaneous nephrolithotomy (PCNL).

Methods: A retrospective review was performed of patients undergoing supine mini-PCNL between August 2021 and May 2023. Exclusion criteria were urinary diversion, simultaneous utilisation of >1 laser platform, use of any other form of fragmentation, and ureteric stones.

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates the impact of green tea consumption on venous thromboembolism (VTE) and mortality in cancer patients, highlighting its potential protective benefits against these risks.
  • - Results show that cancer patients who drank green tea had significantly lower rates of VTE and VTE-related deaths compared to those who did not drink green tea, establishing a correlation between green tea intake and improved clinical outcomes.
  • - Patients consuming more than 525 mL of green tea daily experienced even greater reductions in VTE development and mortality rates, suggesting a dose-dependent effect, while overall all-cause mortality rates were similar between the two groups.
View Article and Find Full Text PDF

The degeneration of intervertebral discs is strongly associated with the occurrence of pyroptosis in nucleus pulposus (NP) cells. This pyroptosis is characterized by abnormal metabolism of fatty acids in the degenerative pathological state, which is further exacerbated by the inflammatory microenvironment and degradation of the extracellular matrix. In order to address this issue, we have developed a fibrin hydrogel complex (FG@PEV).

View Article and Find Full Text PDF

Aqueous zinc ion batteries (AZIBs) face significant challenges stemming from Zn dendrite growth and water-contact attack, primarily due to the lack of a well-designed solid electrolyte interphase (SEI) to safeguard the Zn anode. Herein, we report a bio-mass derived polymer of chitin on Zn anode (Zn@chitin) as a novel and robust artificial SEI layer to boost the Zn anode rechargeability. The polymeric chitin SEI layer features both zincophilic and hydrophobic characteristics to target the suppressed dendritic Zn formation as well as the water-induced side reactions, thus harvesting a dendrite-free and corrosion-resistant Zn anode.

View Article and Find Full Text PDF

The whitefly Bemisia tabaci poses a significant threat to various crops and ornamental plants and causes severe damage to the agricultural industry. Over the past few decades, B. tabaci has developed resistance to several pesticides, including imidacloprid.

View Article and Find Full Text PDF