Routine cold storage leads to hyperacute graft loss in pig-to-primate kidney xenotransplantation; hypothermic machine perfusion may be preferred preservation modality in xenotransplantation.

Xenotransplantation (XTx) is an increasingly realistic solution to the organ shortage. Clinical XTx may require off-site procurement in a designated pathogen free (DPF) facility necessitating a period of cold ischemic time during transportation. This study evaluates the impact of different kidney preservation strategies on early graft function in pig-to-baboon XTx in a series of eight cases of pig-to-baboon xenotransplantation performed after five hours of cold ischemic time and compares these results to six cases of pig-to-baboon xenotransplantation performed with minimal ischemic time.

Combined islet and kidney xenotransplantation for diabetic nephropathy: an update in ongoing research for a clinically relevant application of porcine islet transplantation.

Combined islet and kidney xenotransplantation for the treatment of diabetic nephropathy represents a compelling and increasingly relevant therapeutic possibility for an ever-growing number of patients who would benefit from both durable renal replacement and cure of the underlying cause of their renal insufficiency: diabetes. Here we briefly review immune barriers to islet transplantation, highlight preclinical progress in the field, and summarize our experience with combined islet and kidney xenotransplantation, including both challenges with islet-kidney composite grafts as well as our recent success with sequential kidney followed by islet xenotransplantation in a pig-to-baboon model.

Ultrafine PtO nanoparticles coupled with a Co(OH)F nanowire array for enhanced hydrogen evolution.

In this communication, we report the in situ formation of ultrafine PtO nanoparticles coupled with a Co(OH)F nanowire array (PtO-Co(OH)F NA/TM) via a facile hydrothermal treatment. The PtO-Co(OH)F NA/TM possesses interfacial synergy derived from its favorable composition and structure. It can greatly promote water dissociation and optimize the free energy of H* adsorption, indicating high catalytic activity towards the alkaline HER.

Hierarchical CuCoS nanoarrays for high-efficient and durable water oxidation electrocatalysis.

It is highly attractive to design and develop earth-abundant electrocatalysts toward high-efficiency water oxidation electrocatalysis in alkaline media. In this communication, we report the in situ hydrothermal sulfidization preparation of a hierarchical CuCoS nanoarray on copper foam (CuCoS/CF) from its CuCo-hydroxide nanowire array precursor. When used as a 3D catalyst electrode for water oxidation, the as-prepared CuCoS/CF is superior in catalytic activity, demanding overpotentials of only 259 and 295 mV to achieve 60 and 100 mA cm in 1.

Surface Modification of a NiS Nanoarray with Ni(OH) toward Superior Water Reduction Electrocatalysis in Alkaline Media.

Interface engineering has been demonstrated to be effective in promoting hydrogen evolution reaction (HER) in an alkaline solution. Herein, we report that the HER activity of a NiS nanoarray on a titanium mesh (NiS/TM) in alkaline media is greatly boosted by the electrodeposition of Ni(OH) onto NiS [Ni(OH)-NiS/TM]. Ni(OH)-NiS/TM only needs an overpotential of 90 mV to deliver 10 mA cm in 1.

A Zn-doped NiS nanosheet array as a high-performance electrochemical water oxidation catalyst in alkaline solution.

It is of high importance to design efficient electrocatalysts for the oxygen evolution reaction (OER) at alkaline pH. In this communication, we report the development of a Zn-doped NiS nanosheet array on Ni foam (Zn-NiS/NF) as a high-performance and durable electrocatalyst for the OER. Such Zn-NiS/NF drives a catalytic current density of 100 mA cm with the requirement of an OER overpotential of 330 mV, 90 mV less than that for NiS/NF.

High-Performance Non-Enzyme Hydrogen Peroxide Detection in Neutral Solution: Using a Nickel Borate Nanoarray as a 3D Electrochemical Sensor.

It is highly attractive to construct natural enzyme-free nanoarray architecture as a 3D catalyst for hydrogen peroxide detection due to its great specific surface area and easy accessibility to target molecules. In this communication, we demonstrate that nickel borate nanoarray supported on carbon cloth (Ni-Bi/CC) behaves as an efficient catalyst electrode for H O electro-reduction in neutral media. As a non-enzymatic electrochemical H O sensor, such Ni-Bi/CC shows superior sensing performances with a fast response time (less than 3 s), a low detection limit (0.

A Mn-doped NiP nanosheet array: an efficient and durable hydrogen evolution reaction electrocatalyst in alkaline media.

Developing earth-abundant and high-performance electrocatalysts toward the alkaline hydrogen evolution reaction (HER) is highly desired. In this communication, we report a Mn-doped NiP nanosheet array on nickel foam (Mn-NiP/NF) as a high-efficiency electrocatalyst for the HER in alkaline solutions. This Mn-NiP/NF can drive 20 mA cm at an overpotential of 103 mV in 1.

Co O Nanowire Arrays toward Superior Water Oxidation Electrocatalysis in Alkaline Media by Surface Amorphization.

It is highly desirable to develop a simple, fast and straightforward method to boost the alkaline water oxidation of metal oxide catalysts. In this communication, we report our recent finding that the generation of amorphous Co-borate layer on Co O nanowire arrays supported on Ti mesh (Co O @Co-Bi NA/TM) leads to significantly boosted OER activity. The as-prepared Co O @Co-Bi NA/TM demands overpotential of 304 mV to drive a geometrical current density of 20 mA cm in 1.

Benzoate Anion-Intercalated Layered Cobalt Hydroxide Nanoarray: An Efficient Electrocatalyst for the Oxygen Evolution Reaction.

Efficient oxygen evolution reaction (OER) catalysts are highly desired to improve the overall efficiency of electrochemical water splitting. We develop a benzoate anion-intercalated layered cobalt hydroxide nanobelt array on nickel foam (benzoate-Co(OH) /NF) through a one-pot hydrothermal process. As a 3 D electrode, benzoate-Co(OH) /NF with an expanded interlayer spacing (14.

Anion-exchange synthesis of a nanoporous crystalline CoBO nanowire array for high-performance water oxidation electrocatalysis in borate solution.

Developing nanoporous nanoarray electrocatalysts for efficient water oxidation in environmentally benign media is highly desired but still remains a key challenge. In this communication, we report the fabrication of a nanoporous crystalline CoBO nanowire array on Ti mesh (CoBO/TM) from a Co(OH)F nanowire array on Ti mesh (Co(OH)F/TM) via an anion-exchange reaction. As a three dimensional (3D) catalyst electrode for water oxidation, CoBO/TM exhibits superior catalytic activity and needs an overpotential of only 446 mV to drive a geometrical catalytic current density of 10 mA cm in 0.

An amorphous FeMoS nanorod array toward efficient hydrogen evolution electrocatalysis under neutral conditions.

It is highly attractive to develop efficient hydrogen-evolving electrocatalysts under neutral conditions. In this communication, we report an amorphous FeMoS nanorod array on carbon cloth (FeMoS NRA/CC) prepared by hydrothermal treatment of an FeOOH nanorod array on carbon cloth (FeOOH NRA/CC) in (NH)MoS solution. As a 3D electrode for hydrogen evolution electrocatalysis, this FeMoS NRA/CC demonstrates superior catalytic activity and strong long-term electrochemical durability in 1.

Facilitating Active Species Generation by Amorphous NiFe-B Layer Formation on NiFe-LDH Nanoarray for Efficient Electrocatalytic Oxygen Evolution at Alkaline pH.

Searching for a simple and fast strategy to effectively enhance the oxygen evolution reaction (OER) performance of non-noble-metal electrocatalysts in alkaline media remains a significant challenge. Herein, the OER activity of NiFe-LDH nanoarray on carbon cloth (NiFe-LDH/CC) in alkaline media is shown to be greatly boosted by an amorphous NiFe-Borate (NiFe-B ) layer formation on NiFe-layered double hydroxide (NiFe-LDH) surface. Such a NiFe-LDH@NiFe-B /CC catalyst electrode only needs an overpotential of 294 mV to drive 50 mA cm in 1.

Homologous Catalysts Based on Fe-Doped CoP Nanoarrays for High-Performance Full Water Splitting under Benign Conditions.

The design and development of earth-abundant electrocatalysts for efficient full water splitting under mild conditions are highly desired, yet remain a challenging task. A homologous Fe-doped Co-based nanoarray incorporating complementary catalysts is shown to effect high-performance and durable water splitting in near-neutral media. Iron-doped cobalt phosphate borate nanoarray on carbon cloth (Fe-Co-Pi-Bi/CC) derived from iron-doped cobalt phosphide on CC (Fe-CoP/CC) through oxidative polarization behaves as a highly active bimetallic electrocatalyst for water oxidation with an overpotential of 382 mV to afford a catalytic current density of 10 mA cm in 0.

FeNiN nanosheet array: an efficient non-noble-metal electrocatalyst for non-enzymatic glucose sensing.

It is very important to develop enhanced electrochemical sensing platforms for molecular detection and non-noble-metal nanoarray architecture, as electrochemical catalyst electrodes have attracted great attention due to their large specific surface area and easy accessibility to target molecules. In this paper, we demonstrate that an FeNiN nanosheet array grown on Ti mesh (FeNiN NS/TM) shows high electrocatalytic activity toward glucose electrooxidation in alkaline medium. As an electrochemical glucose sensor, such an FeNiN NS/TM catalyst electrode demonstrates superior sensing performance with a short response time of less than 5 s, a wide linear range of 0.

In Situ Derived CoB Nanoarray: A High-Efficiency and Durable 3D Bifunctional Electrocatalyst for Overall Alkaline Water Splitting.

The development of efficient bifunctional catalysts for the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) is of extreme importance for future renewable energy systems. This Communication reports the recent finding that room-temperature treatment of CoO nanowire array on Ti mesh by NaBH in alkaline media leads to in situ development of CoB nanoparticles on nanowire surface. The resulting self-supported CoB@CoO nanoarray behaves as a 3D bifunctional electrocatalyst with high activity and durability for both HER (<17% current density degradation after 20 h electrolysis) and OER (<14% current density degradation after 20 h electrolysis) with the need of the overpotentials of 102 and 290 mV to drive 50 mA cm in 1.

A NiCoO@Ni-Co-Ci core-shell nanowire array as an efficient electrocatalyst for water oxidation at near-neutral pH.

It is attractive but still remains challenging to develop efficient water oxidation electrocatalysts working in a carbonate (Ci) electrolyte. In this communication, we report that a Ni-Co-Ci layer can be developed on a NiCoO nanowire array supported on carbon cloth (NiCoO/CC) via electrochemical surface derivation of NiCoO. The resulting NiCoO@Ni-Co-Ci core-shell nanowire array on carbon cloth (NiCoO@Ni-Co-Ci/CC) exhibits high activity toward water oxidation in 1.

Core-shell CoFeO@Co-Fe-Bi nanoarray: a surface-amorphization water oxidation catalyst operating at near-neutral pH.

The exploration of high-performance and earth-abundant water oxidation catalysts operating under mild conditions is highly attractive and challenging. In this communication, core-shell CoFeO@Co-Fe-Bi nanoarray on carbon cloth (CoFeO@Co-Fe-Bi/CC) was successfully fabricated by in situ surface amorphization of CoFeO nanoarray on CC (CoFeO/CC). As a 3D water oxidation electrode, CoFeO@Co-Fe-Bi/CC shows outstanding activity with an overpotential of 460 mV to drive a geometrical catalytic current density of 10 mA cm in 0.

Bimetallic Nickel-Substituted Cobalt-Borate Nanowire Array: An Earth-Abundant Water Oxidation Electrocatalyst with Superior Activity and Durability at Near Neutral pH.

There is an urgent demand to develop earth-abundant electrocatalysts for efficient and durable water oxidation under mild conditions. A nickel-substituted cobalt-borate nanowire array is developed on carbon cloth (Ni-Co-Bi/CC) via oxidative polarization of NiCo S nanoarray in potassium borate (K-Bi). As a bimetallic electrocatalyst for water oxidation, such Ni-Co-Bi/CC is superior in catalytic activity and durability in 0.

Integrating natural biomass electro-oxidation and hydrogen evolution: using a porous Fe-doped CoP nanosheet array as a bifunctional catalyst.

Electrochemical water splitting has been considered as a promising strategy for hydrogen production, but the sluggish anodic oxygen evolution reaction (OER) limits the efficiency of overall water splitting. In this communication, we report a facile strategy to realize energy-saving hydrogen generation by replacing OER with a thermodynamically more favorable aloe extract (AE) oxidation reaction (AOR). An Fe-doped CoP nanosheet array (Fe-CoP/CC) is used as a bifunctional catalyst for both AOR and hydrogen evolution reaction (HER).

Core-Shell NiFe-LDH@NiFe-B Nanoarray: In Situ Electrochemical Surface Derivation Preparation toward Efficient Water Oxidation Electrocatalysis in near-Neutral Media.

The corrosion issue with acidic and alkaline water electrolyzers can be avoided by developing water oxidation catalysts performing efficiently under benign conditions. In this Letter, we report that a NiFe-borate layer can be generated on a NiFe-layered double hydroxide nanosheet array hydrothermally grown on carbon cloth via an in situ electrochemical surface derivation process in potassium borate (K-B) solution. The resulting 3D NiFe-LDH@NiFe-B nanoarray (NiFe-LDH@NiFe-B/CC) demonstrates high activity for water oxidation, demanding overpotentials of 444 and 363 mV to achieve 10 mA cm in 0.

Three-Dimensional Nickel-Borate Nanosheets Array for Efficient Oxygen Evolution at Near-Neutral pH.

Nickel-borate nanosheets array on titanium mesh (Ni-Bi NA/TM) was derived from NiSe nanosheets array on titanium mesh (NiSe NA/TM) by electrochemical transformation. As a three-dimensional electrode, Ni-Bi NA/TM exhibited high catalytic activity toward the oxygen evolution reaction and required a low overpotential of 430 mV at 10 mA cm in 0.1 m potassium borate (pH 9.

Al-Doped CoP nanoarray: a durable water-splitting electrocatalyst with superhigh activity.

The scalable production of hydrogen fuel through electrochemical water reduction needs efficient Earth-abundant electrocatalysts to make the whole water-splitting process more energy efficient. In this Article, we report that an Al-doped CoP nanoarray on carbon cloth (Al-CoP/CC) behaves as a durable hydrogen evolution electrocatalyst with superhigh activity in 0.5 M HSO.

NiCoP Nanoarray: A Superior Pseudocapacitor Electrode with High Areal Capacitance.

High-performance supercapacitors require the design and development of electrode materials with high conductivity and a large electrolyte-accessible surface area. Here, the use of a conductive NiCoP nanoarray on nickel foam (NiCoP/NF) as a superior pseudocapacitor electrode is demonstrated. This 3D electrode exhibits high areal capacitances of 9.