Research Advances in Ion Exchange of Halide Perovskites.

In recent years, halide perovskite materials have been extensively studied by researchers due to their excellent optoelectronic characteristics. Unlike traditional semiconductors, halide perovskites possess unique ionic crystal structures, which makes it easier to perform facile composition engineering to tailor their physical and chemical properties. Ion exchange is a popular post-treatment strategy to achieve composition engineering in perovskites, and various ion exchange processes have been used to modify the structural and functional features of prefabricated perovskites to meet the requirements of desired applications.

Antifungal mechanisms of phenyllactic acid against Mucor racemosus: Insights from spore growth suppression, and proteomic analysis.

Mucor, a common mold, is a major cause of post-harvest spoilage in sweet cherries, leading to significant economic losses. While previous studies have demonstrated that phenyllactic acid (PLA) exhibits potent antifungal activity against Mucor, its underlying mechanism remains unclear. Here, we probed into the efficacy of PLA in inhibiting Mucor spore growth and explored its mechanisms of action.

Physiological and transcriptome analysis reveals the mechanism of Gymnocarpos przewalskii response to drought stress.

Background: Gymnocarpos przewalskii Bunge ex Maxim. (G. przewalskii) is an endangered xerophytic shrub that plays a crucial role as a source of forage in the Alxa Desert.

Comparative Analyses of Gut Microbiomes in (Coleoptera: Meloidae) Adults Reveal Their Distinct Microbes, Microbial Diversity and Composition Associated to Food.

Gut microbiota crucially affects metabolism and health. Linnaeus has been listed as a medicinal insect in the Pharmacopeia of the People's Republic of China due to the presence of cantharidin, which has a curative effect on many cancers and skin diseases. In order to analyze the effects of dietary habits and gender on the diversity and composition of gut microbiota in and provide a basis for an artificial diet, in this study, the full-length 16S rRNA sequencing technology was used to analyze the gut microbiota of 35 adults, including wild female adults (WFA), wild male adults (WMA), female adults fed with luffa flowers (LFA), male adults fed with luffa flowers (LMA), female adults fed with artificial diet (AFA), and male adults fed with artificial diet (AMA).

Efficacy of virtual reality balance training on rehabilitation outcomes following anterior cruciate ligament reconstruction: A systematic review and meta-analysis.

Objective: The objective of this systematic review and meta-analysis is to clarify the rehabilitation efficacy of virtual reality (VR) balance training after anterior cruciate ligament reconstruction (ACLR).

Methods: This meta-analysis was registered in PROSPERO with the registration number CRD42024520383. The electronic databases PubMed, Web of Science, Cochrane Library, MEDLINE, Embase, China National Knowledge Infrastructure, Chinese Biomedical Literature, China Science and Technology Journal Database, and Wanfang Digital Periodical database were systematically searched to identify eligible studies from their inception up to January 2024.

Preclinical and First-in-Human Study of a Compact Radionuclide Labeled Self-Assembly Nanomedicine for Chemo-Radio-Theranostics of Cancer.

The emerging combination of chemotherapy and radionuclide therapy has been actively investigated to overcome the limitations of monotherapy and augment therapeutic efficacy. However, it remains a challenge to design a single delivery vehicle that can incorporate chemotherapeutics and radionuclides into a compact structure. Here, a chelator DOTA- or NOTA-modified Evans blue conjugated camptothecin molecule (EB-CPT) nanoprodrug was synthesized, which could self-assemble into nanoparticles due to its inherent amphiphilicity.

Long non-coding RNA CAR10 promotes angiogenesis of lung adenocarcinoma by mediating nuclear LDHA to epigenetically regulate VEGFA/C.

Angiogenesis is a significant character of lung adenocarcinoma (LUAD) and is an important reason leading to high mortality rates of LUAD patients. However, the molecular mechanisms of lncRNAs regulating the angiogenesis in LUAD have not been fully elucidated. Here we show lncRNA chromatin-associated RNA 10 (CAR10) was upregulated in the tumor tissue of patients with LUAD and enhanced tumor metastasis.

Prediction of the likelihood of conception to first or second insemination in Chinese Holstein cows using milk Fourier transformed infrared spectroscopy.

Accurate identification of cows' likelihood of conception during the period from recent calving to the first artificial insemination (AI) will provide assistance in managing the fertility of dairy cows and contribute to the economic prosperity and sustainability of the farm. The purpose of this study was to use FTIR spectroscopy collected from recent calving to the first artificial insemination (AI) to predict the cow's likelihood of conception to first AI, first or second AI. This study specifically focused on the role of FTIR spectral and farm data collected at different time windows in improving the accuracy of model for predicting the cow's likelihood of conception to first AI, first or second AI.

A novel potential measurement indicator with objective and quantitative effect for trigeminal neuralgia: fractional anisotropy in MR-DTI.

Objectives: To investigate the effect of diffusivity metrics of magnetic resonance diffusion tensor imaging (MR-DTI) in the assessment of treatment effects.

Methods: MR-DTI examination for trigeminal neuralgia (TN) patients and the diffusivity metrics of the trigeminal ganglion (TG) were analyzed. Before and after the percutaneous stereotactic radiofrequency rhizotomy (PSR) operation, the treatment effect was assessed using pain scores and MR-DTI.

Chromosome-level genome assemblies of sunflower oilseed and confectionery cultivars.

The sunflower (Helianthus annuus L.), belonging to the Asteraceae family, is the world's fourth most important oil crop. Sunflower cultivars are categorized into oilseed and confectionery types.

Evaluating the performance and stability of microalgal-bacterial granular sludge in municipal wastewater treatment plants.

The microalgal-bacterial granular sludge (MBGS) process shows potential for carbon-neutral wastewater treatment, yet its application in wastewater treatment plants remains underexplored. This study attempted to use a continuous-flow raceway reactor to treat real municipal wastewater using the MBGS process. The results showed that the removal efficiencies of organics peaked on the fifth day, while declining trends were observed for nitrogen and phosphorus removal.

Multivariate analysis between environmental factors and fruit quality of citrus at the core navel orange-producing area in China.

Gannan is the largest navel orange production area in China. Most studies have primarily focused on the effects of either soil or topographic factors on the quality of navel oranges. However, there has been a lack of research exploring the relationship between navel orange quality and multiple environmental factors (meteorological, topographic, and soil).

Bruceine A inhibits TGF-β1/Smad pathway in pulmonary fibrosis by blocking gal3/TGF-β1 interaction.

Background: Bruceine A(BA) has many pharmacological activities and significantly inhibits fibrosis in keloid fibroblasts. However, the underlying mechanisms have not yet been fully elucidated.

Objective: This study aimed to investigate the effects of BA on pulmonary fibrosis(PF) and explore its underlying mechanisms.

Milk metabolite profiling of dairy cows as influenced by mastitis.

Mastitis is a disease with frequent incidence in dairy cows, causing huge financial losses to the dairy industry globally. The identification of certain biomarkers is crucial for the early diagnosis and management of mastitis. Metabolomics technology is a useful tool to accurately and efficiently analyze the changes of metabolites in biofluids in response to internal and external stimulations.

Ligand Engineering Achieves Suppression of Temperature Quenching in Pure Green Perovskite Nanocrystals for Efficient and Thermostable Electroluminescence.

Formamidinium lead bromide (FAPbBr) perovskite nanocrystals (NCs) are promising for display and lighting due to their ultra-pure green emission. However, the thermal quenching will exacerbate their performance degradation in practical applications, which is a common issue for halide perovskites. Here, we reported the heat-resistant FAPbBr NCs prepared by a ligand-engineered room-temperature synthesis strategy.

Therapeutic co-assemblies for synergistic NSCLC treatment through dual topoisomerase I and tubulin inhibitors.

Camptothecin (CPT) and podophyllotoxin (PPT) function as topoisomerase (TOP) I and tubulin inhibitors, respectively, with potent anticancer effects in a variety of cancers. Despite its promise, the clinical applicability of the combination of CPT and PPT faces challenges, including potential side effect and limited therapeutic efficacy. In this study, we designed co-assembly nanomedicines with the different weight (w/w) ratios of amphiphilic Evans blue conjugated CPT prodrug (EB-ss-CPT) and PPT molecules, denoted as ECT Nano.

The broad-spectrum deubiquitinating enzyme inhibitor PR-619 protects retinal ganglion cell and augments parkin-mediated mitophagy in experimental glaucoma.

Glaucoma is a leading cause of irreversible visual impairment worldwide, characterized by the progressive death of retinal ganglion cells (RGCs). Deubiquitinating enzyme (DUB) inhibitors have shown promise as pharmacological interventions for neurodegenerative disorders. Our study focuses on the pan-DUB inhibitor PR-619 and its potential neuroprotective effects on RGCs through modulation of parkin-mediated mitophagy in experimental glaucoma models.

Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium.

Microbiota and feeding modes influence the susceptibility of premature newborns to necrotizing enterocolitis (NEC) through mechanisms that remain unknown. Here, we show that microbiota colonization facilitated by breastmilk feeding promotes NOD-like receptor family CARD domain containing 5 (Nlrc5) gene expression in mouse intestinal epithelial cells (IECs). Notably, inducible knockout of the Nlrc5 gene in IECs predisposes neonatal mice to NEC-like injury in the small intestine upon viral inflammation in an NK1.

A novel mouse model of hepatocyte-specific apoptosis-induced myeloid cell-dominant sterile liver injury and repair response.

Apoptosis, inflammation, and wound healing are critical pathophysiological events associated with various liver diseases. Currently, there is a lack of in vivo approaches to study hepatocyte apoptosis-induced liver injury and repair. To address this critical knowledge gap, we developed a unique genetically modified mouse model, namely, 3-Transgene (Tg) with inducible Hepatocyte-Specific Apoptosis Phenotype (3xTg-iHAP) in this study.