Publications by authors named "Dtp Buis"
Article Synopsis
- An umbrella review was conducted to evaluate existing evidence on optimal antibiotic treatment durations for various respiratory tract infections, focusing on whether shorter courses are as effective as longer ones.
- The review included systematic reviews of conditions like community-acquired pneumonia and acute sinusitis, assessing factors like clinical outcomes and the quality of the studies using established criteria.
- Findings indicated that most systematic reviews were of low quality, but there was some support for a 5-day treatment duration for community-acquired pneumonia and acute exacerbation of chronic obstructive pulmonary disease; however, reliable evidence for other conditions and shorter durations is lacking.
Article Synopsis
- The study aimed to identify risk factors for acute kidney injury (AKI) and assess its impact on mortality in patients with Staphylococcus aureus bacteraemia (SAB), considering variables like recurrent AKI episodes and competing risks.
- A total of 453 patients were analyzed, revealing that 43% experienced AKI episodes, with age, comorbidity, septic shock, persistent bacteraemia, and vancomycin therapy linked to an increased AKI risk.
- The findings highlighted that AKI significantly raises the risk of 90-day mortality in SAB patients, indicating a worse clinical outcome than previously understood, especially in those treated with vancomycin.
Background: Hospital health care workers (HCW) are at increased risk of contracting SARS-CoV-2. We investigated whether certain behavioral and physical features, e.g.
View Article and Find Full Text PDFBackground: Despite being the leading cause of mortality from bloodstream infections worldwide, little is known about regional variation in treatment practices for Staphylococcus aureus bacteremia (SAB). The aim of this study was to identify global variation in management, diagnostics, and definitions of SAB.
Methods: During a 20-day period in 2022, physicians throughout the world were surveyed on SAB treatment practices.
Introduction: A major knowledge gap in the treatment of complicated bacteraemia (SAB) is the optimal duration of antibiotic therapy. Safe shortening of antibiotic therapy has the potential to reduce adverse drug events, length of hospital stay and costs. The objective of the SAFE trial is to evaluate whether 4 weeks of antibiotic therapy is non-inferior to 6 weeks in patients with complicated SAB.
View Article and Find Full Text PDFBackground: Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly in older patients. Several immunomodulating therapies seem less beneficial in these patients. The biological substrate behind these observations is unknown.
View Article and Find Full Text PDFObjectives: Standard once-daily dosing of ceftriaxone may not lead to adequate antibiotic exposure in all cases of Staphylococcus aureus bacteraemia (SAB). Therefore, we compared clinical effectiveness of empirical antibiotic treatment with flucloxacillin, cefuroxime and ceftriaxone in adult patients with MSSA bacteraemia.
Methods: We analysed data from the Improved Diagnostic Strategies in Staphylococcus aureus bacteraemia (IDISA) study, a multicentre prospective cohort study of adult patients with MSSA bacteraemia.
Article Synopsis
- * High levels of antibodies against HCoV-OC43 were associated with a significantly lower likelihood of testing positive for SARS-CoV-2 compared to those with lower antibody levels.
- * Results suggest that establishing immunity through past HCoV infections, particularly HCoV-OC43, could be valuable in the development of vaccines that target multiple coronaviruses.
Objectives: To determine clinical practice variation and identify knowledge gaps in antibiotic treatment of Staphylococcus aureus bacteraemia (SAB).
Methods: A web-based survey with questions addressing antibiotic treatment of SAB was distributed through the ESGAP network among infectious disease specialists, clinical microbiologists and internists in Croatia, France, Greece, the Netherlands and the UK between July 2021 and November 2021.
Results: A total number of 1687 respondents opened the survey link, of whom 677 (40%) answered at least one question.
Infants may develop severe viral respiratory tract infections because their immune system is still developing in the first months after birth. Human milk provides passive humoral immunity during the first months of life. During the COVID-19 pandemic, circulation of common respiratory viruses was virtually absent due to the preventative measures resulting in reduced maternal exposure.
View Article and Find Full Text PDFObjectives: [18F]FDG-PET/CT is used for diagnosing metastatic infections in Staphylococcus aureus bacteremia (SAB) and guidance of antibiotic treatment. The impact of [18F]FDG-PET/CT on outcomes remains to be determined. The aim of this systematic review was to summarize the effects of [18F]FDG-PET/CT on all-cause mortality and new diagnostic findingsin SAB.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated how often patients with COVID-19 also had bacterial lung infections, focusing on those with positive SARS-CoV-2 tests or high CO-RADS scores.
- Conducted from March to June 2020, the research involved a retrospective analysis of COVID-19 patients, categorizing them as unlikely, possible, or probable for bacterial co-infection based on clinical and laboratory data.
- Findings revealed that 82.9% of patients were unlikely to have bacterial co-infections, suggesting that antibiotics should be used sparingly in COVID-19 cases, as 81% of all patients received them within 72 hours despite low co-infection rates.
Importance: It is unclear when, where, and by whom health care workers (HCWs) working in hospitals are infected with SARS-CoV-2.
Objective: To determine how often and in what manner nosocomial SARS-CoV-2 infection occurs in HCW groups with varying exposure to patients with COVID-19.
Design, Setting, And Participants: This cohort study comprised 4 weekly measurements of SARS-CoV-2-specific antibodies and collection of questionnaires from March 23 to June 25, 2020, combined with phylogenetic and epidemiologic transmission analyses at 2 university hospitals in the Netherlands.
Background: The adipocyte-derived hormone leptin has been associated with altered blood coagulation in in vitro studies. However, it is unclear whether this association is relevant in vivo and to what extent this association is influenced by total body fat. Therefore, we aimed to examine the association between serum leptin and blood coagulation while taking total body fat into account in a population-based cohort study.
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- The study explores the genetic factors influencing the risk and protection against type 1 diabetes (T1D), focusing on specific HLA genotypes DQ2/8 and DQ6/8.
- It proposes that DQ6 plays a protective role by "stealing" islet epitopes, limiting the ability of the disease-susceptible DQ8 to present those peptides.
- The findings suggest a unique peptide-binding mechanism in DQ6 that competes with DQ8, providing insight into how protective genotypes can influence immune responses to prevent T1D.