The novel HLA-A*02:1152 and HLA-B*40:566 alleles identified in Russian bone marrow donors.

Identification of two novel HLA alleles in Russian bone marrow donors.

Detection of the novel HLA-B*55:01:31, HLA-C*07:1113 alleles and confirmation of HLA-C*12:392.

Novel HLA-B*55:01:31, HLA-C*07:1113 alleles and confirmatory HLA-C*12:392 allele were detected during the HLA typing process.

Next generation sequencing identifies two novel HLA alleles, HLA-B*51:395 and HLA-DQB1*06:478.

We identified two novel HLA alleles by NGS, HLA-B*51:395 and HLA-DQB1*06:478.

A single nucleotide substitution in exon 4 produced the novel allele, HLA-C*07:1093.

Characterization of the novel HLA-C*07:1093 allele in a Russian female bone marrow donor.

Characterization of the novel HLA-B*13:181 allele by sequencing-based typing.

HLA-B*13:181 differs from HLA-B*13:02:01:01 by one nucleotide substitution in codon 72 in exon 2.

Discovery of the novel HLA-DQB1*06:02:01:32 allele, a variant of HLA-DQB1*06:02:01:01, in a Russian individual.

One nucleotide substitution in pseudoexon 5 of HLA-DQB1*06:02:01:01 results in a novel allele, HLA-DQB1*06:02:01:32.

Distributions of HLA-A, -B, -C, -DRB1 and -DQB1 alleles typed by next generation sequencing in Russian volunteer donors.

HLA genes play a major role for successful hematopoietic stem cell transplantation (HSCT). While the success of HSCT depends on a HLA compatibility between donor and patient, finding a suitable donor remains challenging because of the high polymorphic nature of HLA genes. In this study, HLA-A, -B, -C, -DRB1 and -DQB1 alleles were genotyped at the 3-fields resolution level using MiSeq Illumina of 3341 Russian volunteers from the Kirov bone marrow Registry.

Recognition of the novel HLA-DQB1*05:02:01:15 allele in a Russian bone marrow donor.

One nucleotide substitution in pseudoexon 5 of HLA-DQB1*05:02:01:01 results in a novel allele, HLA-DQB1*05:02:01:15.

Identification of three new HLA alleles, HLA-A*68:298, HLA-C*07:1054N and HLA-DRB1*15:216.

Three new HLA alleles characterized by next-generation sequencing, HLA-A*68:298, HLA-C*07:1054N and HLA-DRB1*15:216.

Characterization of the novel HLA-DQB1*02:02:23 allele in a Russian hematopoietic stem cell donor.

HLA-DQB1*02:02:23 differs from HLA-DQB1*02:02:01:01 by one synonymous nucleotide substitution at codon -6 in exon 1.

Two new HLA alleles, HLA-B*58:140 and -DRB1*07:145, detected in inhabitants from Russia.

Two novel HLA alleles, HLA-B*58:140 and HLA-DRB1*07:145, were identified.

Recognition of an HLA-DQB1*06:319 variant, HLA-DQB1*06:319:02, in an hematopoietic stem cell donor.

One nucleotide replacement in codon 27 of HLA-DQB1*06:319:01 results in a novel allele, HLA-DQB1*06:319:02.

Characterization of two new alleles: HLA-B*51:363 and HLA-DRB1*13:322N.

Two new HLA alleles were identified during routine next generation sequencing.

Genomic full-length sequence of the HLA-B*44:348 allele was identified by next generation sequencing.

Genomic full-length sequence of the HLA-B*44:348 allele was identified by next generation sequencing in a Russian individual.

Characterization of the novel HLA-DRB1*13:03:12 allele by two next-generation sequencing methods.

The novel HLA-DRB1*13:03:12 allele was characterized using two next-generation sequencing technologies.

Characterization of seven new HLA alleles, HLA-A*01:407, -A*01:408, -A*03:434, -B*40:508N, -B*40:511N, -DRB1*04:336, and -DRB1*11:297Q.

Seven novel HLA alleles, HLA-A*01:407, -A*01:408, -A*03:434, -B*40:508N, -B*40:511N, -DRB1*04:336, and -DRB1*11:297Q in individuals from Irkutsk Region.

Detection of the HLA-A*68:99:02 allele in a Russian unrelated hematopoietic cell donor.

Identification of the novel HLA-A*68:99:02 allele that differs from HLA-A*68:99:01 in exon 2 and intron 7.