Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD.

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects one-third of the global population. Understanding the metabolic pathways involved can provide insights into disease progression and treatment. Untargeted metabolomics of livers from mice with early-stage steatosis uncovered decreased methylated metabolites, suggesting altered one-carbon metabolism.

Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality.

In recent years, reoviruses have been of major interest in immunotherapy because of their oncolytic properties. Preclinical and clinical trials, in which reovirus was used for the treatment of melanoma and glioblastoma, have paved the way for future clinical use of reovirus. However, little is known about how reovirus infection affects the tumor microenvironment and immune response towards infected tumor cells.

Jet-Cooled Phosphorescence Excitation Spectrum of the T(n,π*) ← S Transition of 4-Pyran-4-one.

The 4-pyran-4-one (4PN) molecule is a cyclic conjugated enone with spectroscopically accessible singlet and triplet (n,π*)excited states. Vibronic spectra of 4PN provide a stringent test of electronic-structure calculations, through comparison of predicted vs measured vibrational frequencies in the excited state. We report here the T(n,π*) ← S phosphorescence excitation spectrum of 4PN, recorded under the cooling conditions of a supersonic free-jet expansion.

Fatty liver-mediated glycine restriction impairs glutathione synthesis and causes hypersensitization to acetaminophen.

Non-alcoholic fatty liver disease (NAFLD) affects nearly one third of the population worldwide. Understanding metabolic pathways involved can provide insights into disease progression. Untargeted metabolomics of livers from mice with early-stage steatosis indicated a decrease in methylated metabolites suggesting altered one carbon metabolism.

Challenges in Evaluating Interactive Visual Machine Learning Systems.

In interactive visual machine learning (IVML), humans and machine learning algorithms collaborate to achieve tasks mediated by interactive visual interfaces. This human-in-the-loop approach to machine learning brings forth not only numerous intelligibility, trust, and usability issues, but also many open questions with respect to the evaluation of the IVML system, both as separate components, and as a holistic entity that includes both human and machine intelligence. This article describes the challenges and research gaps identified in an IEEE VIS workshop on the evaluation of IVML systems.

Data Visceralization: Enabling Deeper Understanding of Data Using Virtual Reality.

A fundamental part of data visualization is transforming data to map abstract information onto visual attributes. While this abstraction is a powerful basis for data visualization, the connection between the representation and the original underlying data (i.e.

Triplet and Singlet (n,π*) Excited States of 4-Pyran-4-one Characterized by Cavity Ringdown Spectroscopy and Quantum-Chemical Calculations.

The 4-pyran-4-one (4PN) molecule serves as a model for investigating structural changes following π* ← n electronic excitation. We have recorded the cavity ringdown (CRD) absorption spectrum of 4PN vapor at room temperature, over the wavelength region from 350 to 370 nm. This spectral region includes the T(n,π*) ← S band system as well as the low-energy portion of the S(n,π*) ← S system.

FiberClay: Sculpting Three Dimensional Trajectories to Reveal Structural Insights.

Visualizing 3D trajectories to extract insights about their similarities and spatial configuration is a critical task in several domains. Air traffic controllers for example deal with large quantities of aircrafts routes to optimize safety in airspace and neuroscientists attempt to understand neuronal pathways in the human brain by visualizing bundles of fibers from DTI images. Extracting insights from masses of 3D trajectories is challenging as the multiple three dimensional lines have complex geometries, may overlap, cross or even merge with each other, making it impossible to follow individual ones in dense areas.

Augmenting Visualizations with Interactive Data Facts to Facilitate Interpretation and Communication.

Recently, an increasing number of visualization systems have begun to incorporate natural language generation (NLG) capabilities into their interfaces. NLG-based visualization systems typically leverage a suite of statistical functions to automatically extract key facts about the underlying data and surface them as natural language sentences alongside visualizations. With current systems, users are typically required to read the system-generated sentences and mentally map them back to the accompanying visualization.

ATOM: A Grammar for Unit Visualizations.

Unit visualizations are a family of visualizations where every data item is represented by a unique visual mark-a visual unit-during visual encoding. For certain datasets and tasks, unit visualizations can provide more information, better match the user's mental model, and enable novel interactions compared to traditional aggregated visualizations. Current visualization grammars cannot fully describe the unit visualization family.

Thorium complexes possessing expanded ring N-heterocyclic iminato ligands: synthesis and applications.

Six and seven membered N-heterocyclic iminato ligands (L) are introduced allowing access a new class of Th(iv) complexes of the type Cp*Th(L)(CH). These complexes were studied in the Tishchenko reaction. Stoichiometric reactions together with kinetic and thermodynamic studies permit us to propose a plausible mechanism.

Cavity Ringdown Spectrum of 2-Cyclohexen-1-one in the CO/Alkenyl CC Stretch Region of the S(n, π*)-S Vibronic Band System.

The 2-cyclohexen-1-one (2CHO) molecule serves as a prototype for understanding the photochemical properties of conjugated enones. We have recorded the cavity ringdown (CRD) absorption spectrum of 2CHO vapor at room temperature over the 360-380 nm range. This portion of the spectrum encompasses the S(n,π*) ← S vibronic band system in the region of the C═C and C═O stretch fundamentals.

Iterating between Tools to Create and Edit Visualizations.

A common workflow for visualization designers begins with a generative tool, like D3 or Processing, to create the initial visualization; and proceeds to a drawing tool, like Adobe Illustrator or Inkscape, for editing and cleaning. Unfortunately, this is typically a one-way process: once a visualization is exported from the generative tool into a drawing tool, it is difficult to make further, data-driven changes. In this paper, we propose a bridge model to allow designers to bring their work back from the drawing tool to re-edit in the generative tool.

Development of an Experimental Setup for the Measurement of the Coefficient of Restitution under Vacuum Conditions.

The Discrete Element Method is used for the simulation of particulate systems to describe and analyze them, to predict and afterwards optimize their behavior for single stages of a process or even an entire process. For the simulation with occurring particle-particle and particle-wall contacts, the value of the coefficient of restitution is required. It can be determined experimentally.

PanoramicData: Data Analysis through Pen & Touch.

Interactively exploring multidimensional datasets requires frequent switching among a range of distinct but inter-related tasks (e.g., producing different visuals based on different column sets, calculating new variables, and observing the interactions between sets of data).

Lowest triplet (n,π*) state of 2-cyclohexen-1-one: characterization by cavity ringdown spectroscopy and quantum-chemical calculations.

The cavity ringdown (CRD) absorption spectrum of 2-cyclohexen-1-one (2CHO) was recorded over the range 401.5-410.5 nm in a room-temperature gas cell.

A deeper understanding of sequence in narrative visualization.

Conveying a narrative with visualizations often requires choosing an order in which to present visualizations. While evidence exists that narrative sequencing in traditional stories can affect comprehension and memory, little is known about how sequencing choices affect narrative visualization. We consider the forms and reactions to sequencing in narrative visualization presentations to provide a deeper understanding with a focus on linear, 'slideshow-style' presentations.

Lowest triplet (n, π*) electronic state of acrolein: determination of structural parameters by cavity ringdown spectroscopy and quantum-chemical methods.

The cavity ringdown absorption spectrum of acrolein (propenal, CH(2)=CH-CH=O) was recorded near 412 nm, under bulk-gas conditions at room temperature and in a free-jet expansion. The measured spectral region includes the 0(0)(0) band of the T(1)(n, π*) ← S(0) system. We analyzed the 0(0)(0) rotational contour by using the STROTA computer program [R.

Periodontal probing calibration in an academic setting.

The purpose of this study was to locate the common discrepancy sites in a periodontal examination by new student dentists in a dental school setting and to evaluate student progress after one year of clinical training. Sixty-nine patients were enrolled in the initial phase of this study. Periodontal probing examinations were performed by both dental students and calibrated faculty members.

The relationship between root hydraulics and scion vigour across Vitis rootstocks: what role do root aquaporins play?

Vitis vinifera scions are commonly grafted onto rootstocks of other grape species to influence scion vigour and provide resistance to soil-borne pests and abiotic stress; however, the mechanisms by which rootstocks affect scion physiology remain unknown. This study characterized the hydraulic physiology of Vitis rootstocks that vary in vigour classification by investigating aquaporin (VvPIP) gene expression, fine-root hydraulic conductivity (Lp(r)), % aquaporin contribution to Lp(r), scion transpiration, and the size of root systems. Expression of several VvPIP genes was consistently greater in higher-vigour rootstocks under favourable growing conditions in a variety of media and in root tips compared to mature fine roots.

Exploratory visualization involving incremental, approximate database queries and uncertainty.

Large datasets can mean slow queries, for which users must wait. Incremental visualization systems can give faster results at a cost of accuracy. This article asked analysts to use one and report on their results.

Aneurysmal bone cyst of mandibular condyle: a case report and review of the literature.

An aneurysmal bone cyst (ABC) in the right mandibular condyle and ramus of a 37-year-old woman was surgically resected and immediately reconstructed with a costochondral graft. She was followed up for 5 years. A review of the 10 cases of condylar-ABC available in the literature revealed mean age of 16.

Diving dentistry: a review of the dental implications of scuba diving.

In light of the overwhelming popularity of self-contained underwater breathing apparatus (SCUBA) diving, general dental practitioners should be prepared to address complications arising as a result of diving and to provide patients with accurate information. The aim of this article was to introduce the concepts of diving medicine and dentistry to the dentist, and to supply the dental practitioner with some diagnostic tools as well as treatment guidelines. The literature was reviewed to address diving barotrauma (pressure-induced injury related to an air space) to the head, face and oral regions, as well as scuba mouthpiece-related oral conditions.